Zobrazeno 1 - 10
of 259
pro vyhledávání: '"William L. Dewey"'
Publikováno v:
iScience, Vol 2, Iss , Pp 193-209 (2018)
Summary: In the clinical setting, analgesic tolerance is a primary driver of diminished pain control and opioid dose escalations. Integral to this process are primary afferent sensory neurons, the first-order components of nociceptive sensation. Here
Externí odkaz:
https://doaj.org/article/781b31aa430647c19ffe62b414363f31
Publikováno v:
PLoS ONE, Vol 8, Iss 5 (2013)
Externí odkaz:
https://doaj.org/article/761772fbcb5f44b3a032f350342fac42
Autor:
Boshi Huang, Mengchu Li, Pornprom Klongkumnuankarn, Rolando E. Mendez, James C. Gillespie, David L. Stevens, William L. Dewey, Dana E. Selley, Yan Zhang
Publikováno v:
Journal of Medicinal Chemistry. 65:4991-5003
Opioid-induced constipation (OIC) is a common adverse effect of opioid analgesics. Peripherally acting μ opioid receptor antagonists (PAMORAs) can be applied in the treatment of OIC without compromising the analgesic effects. NAP, a 6β-N-4-pyridyl-
Autor:
Piyusha P. Pagare, Mengchu Li, Yi Zheng, Abhishek S. Kulkarni, Samuel Obeng, Boshi Huang, Christian Ruiz, James C. Gillespie, Rolando E. Mendez, David L. Stevens, Justin L. Poklis, Matthew S. Halquist, William L. Dewey, Dana E. Selley, Yan Zhang
Publikováno v:
J Med Chem
The μ opioid receptor (MOR) has been an intrinsic target to develop treatment of opioid use disorders (OUD). Herein, we report our efforts on developing centrally acting MOR antagonists by structural modifications of 17-cyclopropylmethyl-3,14-dihydr
Autor:
Hongguang Ma, Piyusha P. Pagare, Mengchu Li, Logan T. Neel, Rolando E. Mendez, James C. Gillespie, David L. Stevens, William L. Dewey, Dana E. Selley, Yan Zhang
Publikováno v:
Journal of medicinal chemistry.
The search for selective opioid ligands with desired pharmacological potency and improved safety profile has always been an area of interest. Our previous effort yielded a potent opioid modulator, NAN, a 6α
Autor:
Mengchu Li, David L. Stevens, Michelle Arriaga, E. Andrew Townsend, Rolando E. Mendez, Nadejda A. Blajkevch, Dana E. Selley, Matthew L. Banks, S. Stevens Negus, William L. Dewey, Yan Zhang
Publikováno v:
ACS Chem Neurosci
Discovery of analgesics void of abuse liability is critical to battle the opioid crisis in the United States. Among many strategies to achieve this goal, targeting more than one opioid receptor seems promising to minimize this unwanted side effect wh
Autor:
Salvador Sierra, Karan H. Muchhala, Donald K. Jessup, Katherine M. Contreras, Urjita H. Shah, David L. Stevens, Jennifer Jimenez, Xiomara K. Cuno Lavilla, Mario de la Fuente Revenga, Kumiko M. Lippold, Shanwei Shen, Justin L. Poklis, Liya Y. Qiao, William L. Dewey, Hamid I. Akbarali, M. Imad Damaj, Javier González-Maeso
Publikováno v:
Neuropharmacology
Opioids are among the most effective analgesics and the mainstay of pain management. However, concerns about safety and abuse liability have challenged their widespread use by the medical community. Opioid-sparing therapies include drugs that in comb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95feeb11babd86469a7334f6aa4413de
https://europepmc.org/articles/PMC8934299/
https://europepmc.org/articles/PMC8934299/
Autor:
Karan H. Muchhala, Eda Koseli, Aravind R. Gade, Kareem Woods, Suha Minai, Minho Kang, A Rory McQuiston, William L. Dewey, Hamid I. Akbarali
Publikováno v:
J Neuroimmune Pharmacol
The gastrointestinal epithelium is critical for maintaining a symbiotic relationship with commensal microbiota. Chronic morphine exposure can compromise the gut epithelial barrier in mice and lead to dysbiosis. Recently, studies have implicated morph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::474271ff440659006813732d4a10e2c2
https://europepmc.org/articles/PMC9343479/
https://europepmc.org/articles/PMC9343479/
Publikováno v:
Physiology (Bethesda)
Bidirectional interactions of the gut epithelium with commensal bacteria are critical for maintaining homeostasis within the gut. Chronic opioid exposure perturbs gut homeostasis through a multitude of neuro-immune-epithelial mechanisms, resulting in
Publikováno v:
Eur J Pharmacol
β-arrestin-2 has been implicated in the mechanism of opioid-induced antinociceptive tolerance. G-protein-biased agonists with reduced β-arrestin-2 activation are being investigated as safer alternatives to clinically-used opioids. Opioid-induced an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8af01465fb48eeb4aa896b44ec57158
https://europepmc.org/articles/PMC8058323/
https://europepmc.org/articles/PMC8058323/