Zobrazeno 1 - 10
of 137
pro vyhledávání: '"William L. Dean"'
Autor:
Linda Yingqi Lin, Sawyer McCarthy, Barrett M. Powell, Yanti Manurung, Irene M. Xiang, William L. Dean, Brad Chaires, Liliya A. Yatsunyk, Michel M Ouellette
Publikováno v:
PLoS ONE, Vol 15, Iss 11 (2020)
The G-quadruplex (GQ) is a well-studied non-canonical DNA structure formed by G-rich sequences found at telomeres and gene promoters. Biological studies suggest that GQs may play roles in regulating gene expression, DNA replication, and DNA repair. S
Externí odkaz:
https://doaj.org/article/c04cf5d979e245c7bcf91bd7ad7c2e09
Autor:
Santi Mestre-Fos, Petar I Penev, John Colin Richards, William L Dean, Robert D Gray, Jonathan B Chaires, Loren Dean Williams
Publikováno v:
PLoS ONE, Vol 14, Iss 12, p e0226177 (2019)
Mammalian and bird ribosomes are nearly twice the mass of prokaryotic ribosomes in part because of their extraordinarily long rRNA tentacles. Human rRNA tentacles are not fully observable in current three-dimensional structures and their conformation
Externí odkaz:
https://doaj.org/article/d9c87c731498483f8c555473ba91cdd0
Autor:
Robert C Monsen, Lynn W DeLeeuw, William L Dean, Robert D Gray, Srinivas Chakravarthy, Jesse B Hopkins, Jonathan B Chaires, John O Trent
Publikováno v:
Nucleic Acids Research. 50:4127-4147
We report on higher-order G-quadruplex structures adopted by long promoter sequences obtained by an iterative integrated structural biology approach. Our approach uses quantitative biophysical tools (analytical ultracentrifugation, small-angle X-ray
Autor:
Timothy D. Cummins, Teresa Cassel, William L. Dean, Bradford G. Hill, Michael L. Merchant, Teresa W.-M. Fan, Yuting Zheng, Pawel Lorkiewicz, Timothy N. Audam, Kyle L Fulghum
Publikováno v:
Journal of molecular and cellular cardiology
Glucose metabolism comprises numerous amphibolic metabolites that provide precursors for not only the synthesis of cellular building blocks but also for ATP production. In this study, we tested how phosphofructokinase-1 (PFK1) activity controls the f
Autor:
Srinivas Chakravarthy, Robert D. Gray, T. Michael Sabo, Jonathan B. Chaires, John O. Trent, William L. Dean, Lynn DeLeeuw, Robert C. Monsen
Publikováno v:
Nucleic Acids Research
The structure of the 68 nt sequence with G-quadruplex forming potential within the hTERT promoter is disputed. One model features a structure with three stacked parallel G-quadruplex units, while another features an unusual duplex hairpin structure a
Autor:
Vincent Pinkert, Huyen Hoang, Fidelis Manyanga, Jonathan B. Chaires, Megan M. Koslen, William L. Dean, Albert S. Benight, Matthew W. Eskew
Publikováno v:
Advances in Biological Chemistry. :110-134
A capture strategy is described and demonstrated for retrieving ligand entities in plasma that bind Human Serum Albumin. The method has applications for both exogenous and endogenous ligands. Exogenous ligands include drug candidates, performance enh
Publikováno v:
Nucleic Acids Research
Human telomeres contain the repeat DNA sequence 5’(TTAGGG), with duplex regions that are several kilobases long terminating in a 3’ single-stranded overhang. The structure of the single-stranded overhang is not known with certainty, with disparat
Publikováno v:
Protein Science. 27:1585-1599
Protein, DNA, and RNA methyltransferases have an ever-expanding list of novel substrates and catalytic activities. Even within families and between homologs, it is becoming clear the intricacies of methyltransferase specificity and regulation are far
Autor:
Ma. Faye Charmagne A. Carvajal, Siri Ekblad, Ronald L. Koder, Richard J. Wittebort, Jeff Y Chiang, William L. Dean, Kelly Greenland, Jonathan Preston
Publikováno v:
The Journal of Physical Chemistry B. 122:2725-2736
Artificial minielastin constructs have been designed which replicate the structure and function of natural elastins in a simpler context, allowing the NMR observation of structure and dynamics of elastin-like proteins with complete residue-specific r
Autor:
Cheyanne L. Frosti, Kyle D. Webster, Abigail Otto, Kenneth W. Olsen, Dana Dahhan, William L. Dean, Jonathan B. Chaires
Publikováno v:
Artificial Organs. 41:351-358
The development of a blood substitute is urgent due to blood shortages and potential communicable diseases. A novel method, inside-out PEGylation, has been used here to conjugate a multiarm maleimide-PEG (Mal-PEG) to β-cross-linked (βXL-Hb) hemoglo