Zobrazeno 1 - 9
of 9
pro vyhledávání: '"William L. Blake"'
Autor:
Gabriela G. Cezar, Mary B. Bauchmann, Anthony J. Milici, Gretchen E Beckius, Khuram W. Chaudhary, Nestor X. Barrezueta, John D. McNeish, William L. Blake, John E. Hambor, Donald B. Stedman, Anthony Bahinski
Publikováno v:
Toxicological Sciences. 90:149-158
Embryonic stem (ES) cells offer unprecedented opportunities for in vitro drug discovery and safety assessment of compounds. Cardiomyocytes derived from ES cells enable development of predictive cardiotoxicity models to increase the safety of novel dr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a20ef6b9eb9ab5f70ca2b77d98fa163e
https://doi.org/10.1093/toxsci/kfj078
https://doi.org/10.1093/toxsci/kfj078
Publikováno v:
Biochemical and Biophysical Research Communications. 205:1257-1263
Expression of cynomolgus monkey cholesteryl ester transfer protein (CETP) in C57BL/6 mice has been shown to have a profound effect on the lipoprotein profile in those animals. The objective of this study was to examine the effect of CETP expression o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cd7fbf1649f209a5566205de5dee643
https://doi.org/10.1006/bbrc.1994.2800
https://doi.org/10.1006/bbrc.1994.2800
Publikováno v:
Biochemical and Biophysical Research Communications. 177:1056-1061
Rat hepatocytes were maintained in a serum-free, hormonally defined medium supplemented with 50-500 microM albumin-bound 20:1 (n-9) vs 20:4 (n-6). The induction of fatty acid synthase mRNA by a mix of insulin/dexamethasone/T3 was inhibited in a dose
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3e7cadc742b3110d937965838efe77a
https://doi.org/10.1016/0006-291x(91)90645-n
https://doi.org/10.1016/0006-291x(91)90645-n
Autor:
William L. Blake, Steven D. Clarke
Publikováno v:
The Journal of Nutritional Biochemistry. 2:87-90
The objective of this work was to determine if rat liver cell responsiveness to the phosphoinositide cascade agonist vasopressin was influenced by the source of dietary fat. Male Sprague-Dawley rats (185–200 g) were maintained for 21 days on a diet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::81e9117b476b7700e802c41bfea08b63
https://doi.org/10.1016/0955-2863(91)90034-3
https://doi.org/10.1016/0955-2863(91)90034-3
Autor:
Steven D. Clarke, William L. Blake
Publikováno v:
Biochemical and Biophysical Research Communications. 173:87-91
Murine 3T3-L1 cells were cultured in the presence of fetal bovine serum (FBS) washed with an anion exchange resin and charcoal. Using the abundance of a-FABP and fatty acid synthase (FAS) as criteria of differentiation, IGF-1 was found to be 10-fold
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3886445ddfadbf2e1f8594b40fbf21a8
https://doi.org/10.1016/s0006-291x(05)81025-3
https://doi.org/10.1016/s0006-291x(05)81025-3
Autor:
William L. Blake, Steven D. Clarke
Publikováno v:
The Journal of Nutrition. 120:1727-1729
The objective of this research was to determine whether dietary polyunsaturated fatty acids suppress hepatic fatty acid synthase (FAS) mRNA levels by altering FAS gene transcription. Male Sprague-Dawley rats were meal-fed for 10 d a high glucose diet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e389a81d26251bd977e8d2678dca79aa
https://doi.org/10.1093/jn/120.12.1727
https://doi.org/10.1093/jn/120.12.1727
Autor:
Susan L. Kuiper, Beverly Paigen, William L. Blake, Christine K. Castle, George W. Melchior, Keith R. Marotti
Publikováno v:
The American journal of physiology. 274(6)
When the Aygene is expressed in KK mice, the yellow offspring (KKAymice) become obese, insulin resistant, hyperglycemic, and severely hypertriglyceridemic, yet they maintain extraordinarily high plasma high-density lipoprotein (HDL) levels. Mice lack
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0a081bf94ded3bd728f47ad369fdb23
https://pubmed.ncbi.nlm.nih.gov/9611161
https://pubmed.ncbi.nlm.nih.gov/9611161
Publikováno v:
Biochemical and biophysical research communications. 186(1)
Summary EGF has been shown to augment albumin and apolipoprotein A-I secretion by cynomolgus monkey hepatocytes in primary culture without stimulating cell division. This study was undertaken to determine what effect EGF had on apo B secretion by tho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1829466e9a98999459d4afa53096555f
https://pubmed.ncbi.nlm.nih.gov/1632766
https://pubmed.ncbi.nlm.nih.gov/1632766
Autor:
Stephen D. Phinney, William L. Blake, Bonnie Adkins-Finke, Steven D. Clarke, Rosalind Strum-Odin
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism. 921:378-391
The objective of these studies with rat hepatocytes in primary culture was to establish that: (a) membrane phospholipids would become enriched with the specific fatty acid supplemented to the media and (b) hepatocyte monolayer triacylglycerol synthet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::029f26da8a2676783014f55fb35e04a5
https://doi.org/10.1016/0005-2760(87)90040-3
https://doi.org/10.1016/0005-2760(87)90040-3