Consistent expression of guanylyl cyclase-C in primary and metastatic gastrointestinal cancers.

Autor: Hadi Danaee, Thea Kalebic, Timothy Wyant, Matteo Fassan, Claudia Mescoli, Feng Gao, William L Trepicchio, Massimo Rugge

Publikováno v: PLoS ONE, Vol 12, Iss 12, p e0189953 (2017)

The transmembrane receptor guanylate cyclase-C (GCC) has been found to be expressed in colorectal cancers. However, limited data are available on GCC protein expression in non-colorectal gastrointestinal tumors and few studies have reported whether G

Externí odkaz: https://doaj.org/article/076edc77f43846c386adc6a52620dd06

Tumor cell SYK expression modulates the tumor immune microenvironment composition in human cancer via TNF-α dependent signaling

Autor: Adam Aguirre-Ducler, Nicole Gianino, Franz Villarroel-Espindola, Shruti Desai, Daiwei Tang, Hongyu Zhao, Konstantinos Syrigos, William L Trepicchio, Karuppiah Kannan, Richard C Gregory, Kurt A Schalper

Publikováno v: Journal for immunotherapy of cancer. 10(7)

BackgroundThe expression of SYK in cancer cells has been associated with both tumor promoting and tumor suppressive effects. Despite being proposed as anticancer therapeutic target, the possible role of SYK in modulating local adaptive antitumor immu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c25bee36491994393b199c1dc5f5ce6
https://pubmed.ncbi.nlm.nih.gov/35868661

Response to brentuximab vedotin versus physician's choice by CD30 expression and large cell transformation status in patients with mycosis fungoides: An ALCANZA sub-analysis

Autor: Meredith Little, Lisa Brown, José Antonio Sanches, Pietro Quaglino, J. Scarisbrick, Oliver Bechter, Kerry Taylor, David E. Fisher, Matthew Onsum, M. Corinna Palanca-Wessels, Veronica Bunn, Pascal Wolter, Steven M. Horwitz, Jan Walewski, Judith Trotman, Madeleine Duvic, Rudolf Stadler, Lauren C. Pinter-Brown, Herbert Eradat, Reinhard Dummer, Pier Luigi Zinzani, Marise McNeeley, Sean Whittaker, Alejandro A. Gru, Pablo L. Ortiz-Romero, Julie Lisano, H. Miles Prince, Michael Weichenthal, Youn H. Kim, William L. Trepicchio, Oleg E. Akilov

INTRODUCTION: Mycosis fungoides (MF), the most common type of cutaneous T-cell lymphoma, can lead to disfiguring lesions, debilitating pruritus and frequent skin infections. This study assessed response to brentuximab vedotin in patients with MF in t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad3b61df0e6864ee0a19d3ccb015c2ca
https://lirias.kuleuven.be/handle/123456789/674933

Brentuximab vedotin or physician's choice in CD30-positive cutaneous T-cell lymphoma (ALCANZA): an international, open-label, randomised, phase 3, multicentre trial

Autor: H Miles Prince, Youn H Kim, Steven M Horwitz, Reinhard Dummer, Julia Scarisbrick, Pietro Quaglino, Pier Luigi Zinzani, Pascal Wolter, Jose A Sanches, Pablo L Ortiz-Romero, Oleg E Akilov, Larisa Geskin, Judith Trotman, Kerry Taylor, Stephane Dalle, Michael Weichenthal, Jan Walewski, David Fisher, Brigitte Dréno, Rudolf Stadler, Tatyana Feldman, Timothy M Kuzel, Yinghui Wang, Maria Corinna Palanca-Wessels, Erin Zagadailov, William L Trepicchio, Wenwen Zhang, Hui-Min Lin, Yi Liu, Dirk Huebner, Meredith Little, Sean Whittaker, Madeleine Duvic, David Joske, H. Miles Prince, Ian D. Lewis, Constanze Jonak, Franz Trautinger, Oliver Bechter, Dominique Bron, Vladmir Claudio C. de Lima, Jose Antonio Sanches, Richard Klasa, Martine Bagot, Marie Beylot-Barry, Michel D'Incan, Brigitte Dreno, Florent Grange, Jan Nicolay, Marion Wobser, Chalid Assaf, Carmen Loquai, Michele Spina, Alberto Bosi, Pier Paolo Fattori, Aleksandra Grzanka, Andres Lopez-Hernandez, Pablo L. Ortiz-Romero, Jose Juan Rifon Roca, Silvana Novelli Canales, Timothy Illidge, Rod Johnson, Stephen Morris, Pam McKay, Oleg Akilov, Steve Horwitz, Youn H. Kim, Barbara Pro, Timothy Kuzel, Adam Lerner, Herbert Eradat, Lubomir Sokol, David C. Fisher, Sarah Hughey

Publikováno v: The Lancet. 390:555-566

Cutaneous T-cell lymphomas are rare, generally incurable, and associated with reduced quality of life. Present systemic therapies rarely provide reliable and durable responses. We aimed to assess efficacy and safety of brentuximab vedotin versus conv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cce0ee405e66e583edbdaab74473710c
https://doi.org/10.1016/s0140-6736(17)31266-7

Consistent expression of guanylyl cyclase-C in primary and metastatic gastrointestinal cancers

Autor: Feng Gao, Claudia Mescoli, Thea Kalebic, Massimo Rugge, William L. Trepicchio, Matteo Fassan, Tim Wyant, Hadi Danaee

Publikováno v: PLoS ONE
PLoS ONE, Vol 12, Iss 12, p e0189953 (2017)

Background The transmembrane receptor guanylate cyclase-C (GCC) has been found to be expressed in colorectal cancers. However, limited data are available on GCC protein expression in non-colorectal gastrointestinal tumors and few studies have reporte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6b7dfb46afaa61baa25ff99f0a608ee
https://pubmed.ncbi.nlm.nih.gov/29261789