Zobrazeno 1 - 10
of 163
pro vyhledávání: '"William L Holland"'
Autor:
Tara R Price, Donnie S Stapleton, Kathryn L Schueler, Marie K Norris, Brian W Parks, Brian S Yandell, Gary A Churchill, William L Holland, Mark P Keller, Alan D Attie
Publikováno v:
PLoS Genetics, Vol 19, Iss 7, p e1010713 (2023)
We and others have previously shown that genetic association can be used to make causal connections between gene loci and small molecules measured by mass spectrometry in the bloodstream and in tissues. We identified a locus on mouse chromosome 7 whe
Externí odkaz:
https://doaj.org/article/754e612d4ef044c484fffca47c26b6ac
Autor:
Alexandre Caron, Heather M Dungan Lemko, Carlos M Castorena, Teppei Fujikawa, Syann Lee, Caleb C Lord, Newaz Ahmed, Charlotte E Lee, William L Holland, Chen Liu, Joel K Elmquist
Publikováno v:
eLife, Vol 7 (2018)
Leptin is critical for energy balance, glucose homeostasis, and for metabolic and neuroendocrine adaptations to starvation. A prevalent model predicts that leptin’s actions are mediated through pro-opiomelanocortin (POMC) neurons that express lepti
Externí odkaz:
https://doaj.org/article/24478469d7784efb8a6ac25e389c9bb8
Autor:
Kedryn K Baskin, Chad E Grueter, Christine M Kusminski, William L Holland, Angie L Bookout, Santosh Satapati, Y Megan Kong, Shawn C Burgess, Craig R Malloy, Philipp E Scherer, Christopher B Newgard, Rhonda Bassel‐Duby, Eric N Olson
Publikováno v:
EMBO Molecular Medicine, Vol 6, Iss 12, Pp 1610-1621 (2014)
Abstract The heart requires a continuous supply of energy but has little capacity for energy storage and thus relies on exogenous metabolic sources. We previously showed that cardiac MED13 modulates systemic energy homeostasis in mice. Here, we sough
Externí odkaz:
https://doaj.org/article/30c5796f91024edaa0e87fbd9613c8d6
Autor:
Chelsea Hepler, Mengle Shao, Jonathan Y Xia, Alexandra L Ghaben, Mackenzie J Pearson, Lavanya Vishvanath, Ankit X Sharma, Thomas S Morley, William L Holland, Rana K Gupta
Publikováno v:
eLife, Vol 6 (2017)
Visceral adiposity confers significant risk for developing metabolic disease in obesity whereas preferential expansion of subcutaneous white adipose tissue (WAT) appears protective. Unlike subcutaneous WAT, visceral WAT is resistant to adopting a pro
Externí odkaz:
https://doaj.org/article/a1deae3e19564b3796959deac5eab293
Autor:
Teppei Fujikawa, Carlos M Castorena, Mackenzie Pearson, Christine M Kusminski, Newaz Ahmed, Pavan K Battiprolu, Ki Woo Kim, Syann Lee, Joseph A Hill, Philipp E Scherer, William L Holland, Joel K Elmquist
Publikováno v:
eLife, Vol 5 (2016)
Exercise has numerous beneficial metabolic effects. The central nervous system (CNS) is critical for regulating energy balance and coordinating whole body metabolism. However, a role for the CNS in the regulation of metabolism in the context of the e
Externí odkaz:
https://doaj.org/article/6d58bf1dd8944b4c95eeb7c5c29d4ec8
Autor:
Risheng Ye, William L Holland, Ruth Gordillo, Miao Wang, Qiong A Wang, Mengle Shao, Thomas S Morley, Rana K Gupta, Andreas Stahl, Philipp E Scherer
Publikováno v:
eLife, Vol 3 (2014)
As an adipokine in circulation, adiponectin has been extensively studied for its beneficial metabolic effects. While many important functions have been attributed to adiponectin under high-fat diet conditions, little is known about its essential role
Externí odkaz:
https://doaj.org/article/83bf4796034b481d9eb90f452d20685e
Autor:
Yi Zhu, Na Li, Mingyang Huang, Mason Bartels, Sophie Dogné, Shangang Zhao, Xi Chen, Clair Crewe, Leon Straub, Lavanya Vishvanath, Zhuzhen Zhang, Mengle Shao, Yongjie Yang, Christy M. Gliniak, Ruth Gordillo, Gordon I. Smith, William L. Holland, Rana K. Gupta, Bingning Dong, Nathalie Caron, Yong Xu, Yucel Akgul, Samuel Klein, Philipp E. Scherer
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Hyaluronan is a naturally occurring linear polysaccharide that together with collagens, enzymes, and glycoproteins forms the extracellular matrix. Here the authors show that adipose tissue overproduction of Hyaluronan reduces fat accumulation in mice
Externí odkaz:
https://doaj.org/article/d5d6f30432264ee3a4a2783133e16a29
Autor:
Violeta I. Gallardo-Montejano, Chaofeng Yang, Lisa Hahner, John L. McAfee, Joshua A. Johnson, William L. Holland, Rodrigo Fernandez-Valdivia, Perry E. Bickel
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Perilipin 5 is a lipid droplet protein that interacts with PGC1α in the nucleus to regulate mitochondrial metabolism. Here the authors use genetically engineered mouse models to determine the physiologic role of Perilipin 5, and show that it regulat
Externí odkaz:
https://doaj.org/article/426dad6676c648f19a1b00f70052ac14
Autor:
Santhosh Karanth, J.D. Adams, Maria de los Angeles Serrano, Ezekiel B. Quittner-Strom, Judith Simcox, Claudio J. Villanueva, Lale Ozcan, William L. Holland, H. Joseph Yost, Adrian Vella, Amnon Schlegel
Publikováno v:
Cell Reports, Vol 24, Iss 2, Pp 312-319 (2018)
Summary: The common genetic variation at rs8004664 in the FOXN3 gene is independently and significantly associated with fasting blood glucose, but not insulin, in non-diabetic humans. Recently, we reported that primary hepatocytes from rs8004664 hype
Externí odkaz:
https://doaj.org/article/c4f7548fd33b421ea2c46f5ffbc12106
Autor:
Mengle Shao, Lavanya Vishvanath, Napoleon C. Busbuso, Chelsea Hepler, Bo Shan, Ankit X. Sharma, Shiuhwei Chen, Xinxin Yu, Yu A. An, Yi Zhu, William L. Holland, Rana K. Gupta
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
Adipocyte hyperplasia is thought to have beneficial metabolic effects in obesity, but definitive evidence is lacking. Here, Shao et al. promote de novo formation of adipocytes in visceral white adipose tissue (WAT) of adult mice through inducible ove
Externí odkaz:
https://doaj.org/article/6cc640ee069d48bba9a616e022b49eb9