Combined Treatment with PI3K Inhibitors BYL-719 and CAL-101 Is a Promising Antiproliferative Strategy in Human Rhabdomyosarcoma Cells

Autor: Manuela Piazzi, Alberto Bavelloni, Vittoria Cenni, Sara Salucci, Anna Bartoletti Stella, Enrica Tomassini, Katia Scotlandi, William L. Blalock, Irene Faenza

Publikováno v: Molecules, Vol 27, Iss 9, p 2742 (2022)

Rhabdomyosarcoma (RMS) is a highly malignant and metastatic pediatric cancer arising from skeletal muscle myogenic progenitors. Recent studies have shown an important role for AKT signaling in RMS progression. Aberrant activation of the PI3K/AKT axis

Externí odkaz: https://doaj.org/article/04584bf6374340ca95d2de37b203df1a

Extra Virgin Olive Oil (EVOO), a Mediterranean Diet Component, in the Management of Muscle Mass and Function Preservation

Autor: Sara Salucci, Anna Bartoletti-Stella, Alberto Bavelloni, Beatrice Aramini, William L. Blalock, Francesco Fabbri, Ivan Vannini, Vittorio Sambri, Franco Stella, Irene Faenza

Publikováno v: Nutrients. 14:3567

Aging results in a progressive decline in skeletal muscle mass, strength and function, a condition known as sarcopenia. This pathological condition is due to multifactorial processes including physical inactivity, inflammation, oxidative stress, horm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::418bd9c31fb0c1e7e4eec574f4e3048c
https://doi.org/10.3390/nu14173567

Opposing forces fight over the same ground to regulate interferon signaling

Autor: William L Blalock

Publikováno v: The Biochemical journal. 478(10)

The current SARS-CoV-2 pandemic has spurred new interest in interferon signaling in response to viral pathogens. Much of what we know about the signaling molecules and associated signal transduction induced during the host cellular response to viral

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b7f27246212f38fd8cfd352a38eeb08
https://pubmed.ncbi.nlm.nih.gov/34003254

Therapeutic potential of nvp‐bkm120 in human osteosarcomas cells

Autor: William L. Blalock, Giulia Ramazzotti, Enrico Focaccia, Arianna Orsini, Alberto Bavelloni, Manuela Piazzi, Irene Faenza, Lucio Cocco

Publikováno v: Journal of Cellular Physiology. 234:10907-10917

Osteosarcoma (OS) is the most common pediatric malignant neoplasia of the skeletal system. It is characterized by a high degree of malignancy and a severe tendency to metastasize. In the past decade, many studies have provided evidence that the phosp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46aa15c762de57299602e5dd6227d77c
https://doi.org/10.1002/jcp.27911

Cancer therapy and treatments during COVID-19 era

Autor: Monica Notarbartolo, Jörg Bäsecke, Massimo Libra, Giuseppe Montalto, Melchiorre Cervello, Linda S. Steelman, James A. McCubrey, Alberto M. Martelli, Giulia Ramazzotti, Lucio Cocco, Saverio Candido, Shaw M. Akula, Kvin Lerpiriyapong, Stephen L. Abrams, William L. Blalock, Stefano Ratti, Manuela Piazzi, Matilde Y. Follo

Publikováno v: Advances in Biological Regulation
77 (2020). doi:10.1016/j.jbior.2020.100739
info:cnr-pdr/source/autori:Shaw MAkula; Stephen L Abrams; Linda SSteelman; SaverioCandido; MassimoLibra; KvinLerpiriyapong; LucioCocco; GiuliaRamazzotti; Stefano Ratti; Matilde YFollo; Alberto MMartelli; William L Blalock; Manuela Piazzi; Giuseppe Montalto; Melchiorre Cervello; Monica Notarbartolo; Jorg Basecke; James A McCubrey;/titolo:Cancer therapy and treatments during COVID-19 era/doi:10.1016%2Fj.jbior.2020.100739/rivista:Advances in Biological Regulation (Print)/anno:2020/pagina_da:/pagina_a:/intervallo_pagine:/volume:77

The COVID-19 pandemic has put a serious strain on health treatments as well at the economies of many nations. Unfortunately, there is not currently available vaccine for SARS-Cov-2/COVID-19. Various types of patients have delayed treatment or even ro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c69c323af20dd5a069b199c4e1e36d7
http://www.cnr.it/prodotto/i/432820