Zobrazeno 1 - 10
of 236
pro vyhledávání: '"William L, Klein"'
Autor:
Yun Yang, Victor Tapias, Diana Acosta, Hui Xu, Huanlian Chen, Ruchika Bhawal, Elizabeth T. Anderson, Elena Ivanova, Hening Lin, Botir T. Sagdullaev, Jianer Chen, William L. Klein, Kirsten L. Viola, Sam Gandy, Vahram Haroutunian, M. Flint Beal, David Eliezer, Sheng Zhang, Gary E. Gibson
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
Succinylation is a metabolism-associated post-translational protein modification. Here the authors describe changes to the succinylation of proteins in the brain of individuals with Alzheimer’s disease.
Externí odkaz:
https://doaj.org/article/8849caad15a2425b9a9463a3e1b93bff
Autor:
Dang Ngoc Anh Suong, Keiko Imamura, Ikuyo Inoue, Ryotaro Kabai, Satoko Sakamoto, Tatsuya Okumura, Yoshikazu Kato, Takayuki Kondo, Yuichiro Yada, William L. Klein, Akira Watanabe, Haruhisa Inoue
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
Dang Ngoc Anh Suong et al find that vertical mixing generates iPSC-derived brain organoids displaying an inverted structure with neurons localising at the centre and neural progenitors at the outside. This study illustrates the influence of fluid mec
Externí odkaz:
https://doaj.org/article/a797bcfdf0db4887bd3d90226c16748c
Autor:
Craig Weiss, Nicola Bertolino, Daniele Procissi, Grazia Aleppo, Quinn C. Smith, Kirsten L. Viola, Samuel C. Bartley, William L. Klein, John F. Disterhoft
Publikováno v:
Alzheimer’s & Dementia: Translational Research & Clinical Interventions, Vol 8, Iss 1, Pp n/a-n/a (2022)
Abstract Introduction Although mouse models of Alzheimer's disease (AD) have increased our understanding of the molecular basis of the disease, none of those models represent late‐onset Alzheimer's Disease which accounts for >90% of AD cases, and n
Externí odkaz:
https://doaj.org/article/4cd0d89d401245cc9ddee8795292d543
Autor:
Kirsten L. Viola, Maira A. Bicca, Adrian M. Bebenek, Daniel L. Kranz, Vikas Nandwana, Emily A. Waters, Chad R. Haney, Maxwell Lee, Abhay Gupta, Zachary Brahmbhatt, Weijian Huang, Ting-Tung Chang, Anderson Peck, Clarissa Valdez, Vinayak P. Dravid, William L. Klein
Publikováno v:
Frontiers in Neuroscience, Vol 15 (2022)
Improvements have been made in the diagnosis of Alzheimer’s disease (AD), manifesting mostly in the development of in vivo imaging methods that allow for the detection of pathological changes in AD by magnetic resonance imaging (MRI) and positron e
Externí odkaz:
https://doaj.org/article/20581e62a38f44489be8d498e94566f5
Autor:
Nicholas B. Rozema, Daniele Procissi, Nicola Bertolino, Kirsten L. Viola, Vikas Nandwana, Nafay Abdul, Sophia Pribus, Vinayak Dravid, William L. Klein, John F. Disterhoft, Craig Weiss
Publikováno v:
Alzheimer’s & Dementia: Translational Research & Clinical Interventions, Vol 6, Iss 1, Pp n/a-n/a (2020)
Abstract Introduction Amyloid‐beta oligomers (AβOs) accumulate in Alzheimer's disease and may instigate neuronal pathology and cognitive impairment. We examined the ability of a new probe for molecular magnetic resonance imaging (MRI) to detect A
Externí odkaz:
https://doaj.org/article/4a9d5bf8da40413bb587fe6954b90cc7
Autor:
Yu Ding, Jiahui Zhao, Xunle Zhang, Shanshan Wang, Kirsten L. Viola, Frances E. Chow, Yang Zhang, Carol Lippa, William L. Klein, Yuesong Gong
Publikováno v:
Frontiers in Neurology, Vol 10 (2019)
Introduction: β-Amyloid protein (Aβ) putatively plays a seminal role in synaptic loss in Alzheimer's disease (AD). While there is no consensus regarding the synaptic-relevant species of Aβ, it is known that Aβ oligomers (AβOs) are noticeably inc
Externí odkaz:
https://doaj.org/article/9b8b71de082c4f8d8c3cdba7d35749cd
Autor:
Julia R Clarke, Natalia M Lyra e Silva, Claudia P Figueiredo, Rudimar L Frozza, Jose H Ledo, Danielle Beckman, Carlos K Katashima, Daniela Razolli, Bruno M Carvalho, Renata Frazão, Marina A Silveira, Felipe C Ribeiro, Theresa R Bomfim, Fernanda S Neves, William L Klein, Rodrigo Medeiros, Frank M LaFerla, Jose B Carvalheira, Mario J Saad, Douglas P Munoz, Licio A Velloso, Sergio T Ferreira, Fernanda G De Felice
Publikováno v:
EMBO Molecular Medicine, Vol 7, Iss 2, Pp 190-210 (2015)
Abstract Alzheimer's disease (AD) is associated with peripheral metabolic disorders. Clinical/epidemiological data indicate increased risk of diabetes in AD patients. Here, we show that intracerebroventricular infusion of AD‐associated Aβ oligomer
Externí odkaz:
https://doaj.org/article/bfe3876cdb4d49808c5c97e93ba78817
Autor:
William L. Klein
Publikováno v:
Frontiers in Dementia. 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eff236e30732b4238d236890e44bd6ea
https://doi.org/10.3389/frdem.2022.1038003
https://doi.org/10.3389/frdem.2022.1038003
Autor:
Maria Clara Selles, Juliana T.S. Fortuna, Magali C. Cercato, Luis Eduardo Santos, Luciana Domett, Andre L.B. Bitencourt, Mariane Favero Carraro, Amanda S. Souza, Helena Janickova, Jorge M. de Souza, Soniza Alves-Leon, Vania F. Prado, Marco A. M. Prado, Alberto L. Epstein, Anna Salvetti, Ottavio Arancio, William L. Klein, Adriano Sebollela, Fernanda G. De Felice, Diana A. Jerusalinsky, Sergio T. Ferreira
Brain accumulation of soluble oligomers of the amyloid-β peptide (AβOs) has been implicated in synapse failure and memory impairment in Alzheimer’s disease. Here, we show that treatment with NUsc1, a single-chain variable fragment antibody (scFv)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1c799d8404ca4fad532b4c7c4175c970
https://doi.org/10.1101/2022.06.10.495369
https://doi.org/10.1101/2022.06.10.495369
Autor:
Tamás F. Freund, William L. Klein, Lindsay A. Welikovitch, János Lőke, A. Claudio Cuello, Sonia Do Carmo, Zsófia Maglóczky, Janice C. Malcolm
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance This work provides evidence that soluble and oligomeric amyloid protein stokes neuronal inflammation during the earliest stages of Alzheimer’s disease. Identifying neuron-derived factors that engage the brain’s immune system will pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4461159421af49b4f4f22d036c620616
https://doi.org/10.1073/pnas.1914593117
https://doi.org/10.1073/pnas.1914593117