Zobrazeno 1 - 9 of 9 pro vyhledávání: '"William Kissel"'
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Stereoselective Synthesis of (S)-3-(Methylamino)-3-((R)-pyrrolidin-3-yl)propanenitrile
Autor: William Kissel, Murphy Sean, Brian Samas, Garrett Hoge, Edmund L. Ellsworth, Tuan P. Tran, H. D. Hollis Showalter, Kim Hutchings, Clarke Taylor, Timothy Curran, Manjinder S. Lall
Publikováno v: The Journal of Organic Chemistry. 77:4732-4739
(S)-3-(methylamino)-3-((R)-pyrrolidin-3-yl)propanenitrile (1) is a key intermediate in the preparation of PF-00951966, (1) a fluoroquinolone antibiotic for use against key pathogens causing community-acquired respiratory tract infections including mu
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d92db3fa65aaaacd0aa3a41dd5d7975a
https://doi.org/10.1021/jo3004716
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3
Process Development of CP-481715, a Novel CCR1 Antagonist
Autor: Kathleen S. Zandi, William Kissel, Brian M. Andresen, Chiu Charles K, John Charles Kath, David C. Whritenour, Matthew Frank Brown, Tung Le, Z. Jane Li, Eric Dias, Richard A. Buzon, Michel Couturier, Bryan Li, John L. Tucker, V. John Jasys, Joanna Teresa Negri, Poss Christopher Stanley, Frank J. Urban
Publikováno v: Organic Process Research & Development. 9:466-471
Process development for the synthesis of 2-quinoxalinecarboxamide, N-[(1S,2S,4R)-4-(aminocarbonyl)-1-[(3-fluorophenyl)methyl]-2,7-dihydroxy-7-methyloctyl] is described. An optimized and streamlined process starting from lactone 2 was developed: Lacto
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2bfdf67bd0fea0a89f37efcd9381a33b
https://doi.org/10.1021/op050059w
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4
Aqueous phosphoric acid as a mild reagent for deprotection of the t-butoxycarbonyl group
Autor: Tung Le, Raymond J. Bemish, Kyle R. Leeman, Lisa Newell, Stephen T. Colgan, Chiu Charles K, Bryan Li, Richard A. Buzon, William Kissel, Joshua Roth
Publikováno v: Tetrahedron Letters. 44:8113-8115
Aqueous phosphoric acid (85 wt%) is an efficient and mild reagent for the deprotection of N-BOC groups. Acid sensitive functionalities including benzyl and methyl esters, TBDMS ether, CBZ and isopropylidene groups are compatible with the reaction con
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9470133506867cd38053ade09ceb869e
https://doi.org/10.1016/j.tetlet.2003.09.040
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5
Development of a Practical Synthesis of Novel, Pyrrole-Based HMG-CoA Reductase Inhibitors
Autor: Steven R. Miller, Scott D. Larsen, Yuntao Song, David C. Boyles, Jeffrey A. Pfefferkorn, Chulho Choi, William Kissel, Bharat K. Trivedi, Daniel Merritt Bowles, Kuai Lin Sun
Publikováno v: ChemInform. 38
This paper describes the development of an efficient and scalable second generation synthesis of novel, pyrrole-based HMG-CoA reductase inhibitors. Compound 1 was identified as part of a discovery program aimed at finding improved treatments for hype
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c135c7e5597e87adaacda948a6c81bb
https://doi.org/10.1002/chin.200748103
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6
Aqueous phosphoric acid as a mild reagent for deprotection of tert-butyl carbamates, esters, and ethers
Autor: Chiu Charles K, Ronald Morris, Silke Wunderwald, Kyle R. Leeman, Richard A. Buzon, Tung Le, Nandell F. Keene, Takushi Kaneko, Zhongli Zhang, Lisa Newell, John D. Weaver, Stephen T. Colgan, Michael F. Witt, Brian L. Marquez, William Kissel, Bryan Li, Martin A. Berliner, Zhijun Zhang
Publikováno v: The Journal of organic chemistry. 71(24)
Aqueous phosphoric acid (85 wt %) is an effective, environmentally benign reagent for the deprotection of tert-butyl carbamates, tert-butyl esters, and tert-butyl ethers. The reaction conditions are mild and offer good selectivity in the presence of
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16585cc97001c77a93d0d6018913b0aa
https://pubmed.ncbi.nlm.nih.gov/17109528
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8
Highly selective asymmetric hydrogenation using a three hindered quadrant bisphosphine rhodium catalyst
Autor: Greene Derek Joseph, Garrett Hoge, William Kissel, Derek A. Pflum, He-Ping Wu, Jian Bao
Publikováno v: Journal of the American Chemical Society. 126(19)
A concise synthesis of both enantiomers of ligand 2 and rhodium complex 5 is presented. The crux of the synthesis is a chiral HPLC separation of the enantiomers of 4. Rhodium complex 5 possesses three hindered quadrants in the steric environment with
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8573ed7d8e82887c0948dbdab9a97708
https://pubmed.ncbi.nlm.nih.gov/15137752
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