Zobrazeno 1 - 10
of 13
pro vyhledávání: '"William Keyes"'
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-9 (2021)
Salman Sohrabi et al. develop an automated, high-throughput assay to study spasm-like curling behavior in C. elegans, which is related to motor control symptoms in Parkinson’s disease. They apply this screening approach to identify four candidate d
Externí odkaz:
https://doaj.org/article/74da37c3af4d4181ad273528c6947316
Autor:
Chen Lesnik, Salman Sohrabi, Jasmine M. Ashraf, Rachel Kaletsky, Vanessa Cota, Titas Sengupta, William Keyes, Coleen T. Murphy
SummaryReproductive aging is one of the earliest aging phenotypes, and mitochondrial dysfunction has been linked to a decline in oocyte quality. However, the mitochondria-related processes that are critical for oocyte quality maintenance with age hav
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f23853468ff73897d562a6cbaea95970
https://doi.org/10.1101/2023.02.09.527915
https://doi.org/10.1101/2023.02.09.527915
Publikováno v:
Communications Biology
Communications Biology, Vol 4, Iss 1, Pp 1-9 (2021)
Communications Biology, Vol 4, Iss 1, Pp 1-9 (2021)
We recently linked branched-chain amino acid transferase 1 (BCAT1) dysfunction with the movement disorder Parkinson’s disease (PD), and found that RNAi-mediated knockdown of neuronal bcat-1 in C. elegans causes abnormal spasm-like ‘curling’ beh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8523d3a5759e15a4db741608b46f8d56
http://europepmc.org/articles/PMC7884385
http://europepmc.org/articles/PMC7884385
Autor:
Rachel Kaletsky, Gary W. Miller, Salman Sohrabi, Coleen T. Murphy, Alp Tartici, Danielle Emille Mor, Vrinda Kalia, William Keyes
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Uncovering the role of defective metabolism in Parkinson’s disease (PD) may lead to the discovery of disease-modifying therapies. We recently linked branched-chain amino acid (BCAA) metabolism with PD, yet the underlying mechanisms wer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad691238a4b1bf1fb561da872ef8240a
https://pubmed.ncbi.nlm.nih.gov/33024014
https://pubmed.ncbi.nlm.nih.gov/33024014
Evolutionarily conserved signaling pathways are crucial for adjusting growth, reproduction, and cell maintenance in response to altered environmental conditions or energy balance. However, we have an incomplete understanding of the signaling networks
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e06360a064e8f61fdbde21e3463ff461
Autor:
Rachel Kaletsky, Kalia, Danielle Emille Mor, William Keyes, Salman Sohrabi, Coleen T. Murphy, Gary W. Miller
Metabolic dysfunction is a facet of many age-related neurodegenerative diseases, yet its role in disease etiology remains poorly understood1. We recently discovered a potential causal link between the branched-chain amino acid transferase, BCAT-1, an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af167037f598bf1d27d9e993c9fabe03
Autor:
Danielle Emille Mor, Coleen T. Murphy, Victoria Yao, William Keyes, Olga G. Troyanskaya, Salman Sohrabi, Aaron K. Wong, Rachel Kaletsky
Publikováno v:
Nature Biotechnology. 36:1091-1099
Effective discovery of causal disease genes must overcome the statistical challenges of quantitative genetics studies and the practical limitations of human biology experiments. Here we developed diseaseQUEST, an integrative approach that combines da
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2aa3a52e389ecbcfc4214dc541072602
https://doi.org/10.1038/nbt.4246
https://doi.org/10.1038/nbt.4246
Publikováno v:
Dev Cell
Evolutionarily conserved signaling pathways are crucial for adjusting growth, reproduction, and cell maintenance in response to altered environmental conditions or energy balance. However, we have an incomplete understanding of the signaling networks
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::819465348e02cfbeaded1438ba334ac1
https://doi.org/10.1016/j.devcel.2020.05.023
https://doi.org/10.1016/j.devcel.2020.05.023
Autor:
Cheng Shi, Rachel Kaletsky, Shijing Luo, Jasmine Ashraf, Nicole M. Templeman, William Keyes, Coleen T. Murphy
Publikováno v:
Current Biology. 28:753-760.e4
Summary A decline in female reproduction is one of the earliest hallmarks of aging in many animals, including invertebrates and mammals [1–4]. The insulin/insulin-like growth factor-1 signaling (IIS) pathway has a conserved role in regulating longe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c950f7221e6c4762e03b3f1579817ca
https://doi.org/10.1016/j.cub.2018.01.052
https://doi.org/10.1016/j.cub.2018.01.052
Autor:
Eric Blanc, Martin Regenass, Zhunan Chen, Deniz Sifoglu, Hang Lu, Joy Alcedo, Astrid Cornils, Isaac F. López-Moyado, Yu Shen, Yongmin Cho, Coleen T. Murphy, Anca Neagu, Ivan Ostojic, Quee-Lim Ch'ng, Zachary M. Nash, Attila Csikász-Nagy, Federico Vaggi, Chang Liu, William Keyes, Nicholas Stroustrup, KyungHwa Lee, Diana Andrea Fernandes de Abreu, Antonio Caballero, Javier Apfeld, Adam Antebi, Pascal Fardel, Yun Zhang, Walter Fontana
Publikováno v:
PLoS Genetics
PLoS Genet
Fernandes de Abreu, D, Caballero Reyes, A, Fardel, P, Stroustrup, N, Chen, Z, Lee, K, Keyes, W D, Nash, Z M, López-Moyado, I F, Vaggi, F, Cornils, A, Regenass, M, Neagu, A, Ostojic, I, Liu, M, Cho, Y, Sifoglu, D, Shen, Y, Fontana, W, Lu, H, Csikasz-Nagy, A, Murphy, C T, Antebi, A, Blanc, E, Apfeld, J, Zhang, Y, Alcedo, J & Ch'ng, Q 2014, ' An insulin-to-insulin regulatory network orchestrates phenotypic specificity in development and physiology ', PL o S Genetics, vol. 10, no. 3, e1004225 . https://doi.org/10.1371/journal.pgen.1004225
PLoS Genetics, Vol 10, Iss 3, p e1004225 (2014)
PLoS Genet
Fernandes de Abreu, D, Caballero Reyes, A, Fardel, P, Stroustrup, N, Chen, Z, Lee, K, Keyes, W D, Nash, Z M, López-Moyado, I F, Vaggi, F, Cornils, A, Regenass, M, Neagu, A, Ostojic, I, Liu, M, Cho, Y, Sifoglu, D, Shen, Y, Fontana, W, Lu, H, Csikasz-Nagy, A, Murphy, C T, Antebi, A, Blanc, E, Apfeld, J, Zhang, Y, Alcedo, J & Ch'ng, Q 2014, ' An insulin-to-insulin regulatory network orchestrates phenotypic specificity in development and physiology ', PL o S Genetics, vol. 10, no. 3, e1004225 . https://doi.org/10.1371/journal.pgen.1004225
PLoS Genetics, Vol 10, Iss 3, p e1004225 (2014)
Insulin-like peptides (ILPs) play highly conserved roles in development and physiology. Most animal genomes encode multiple ILPs. Here we identify mechanisms for how the forty Caenorhabditis elegans ILPs coordinate diverse processes, including develo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d30e5c58fb772ff0a24a414075409da
https://pubmed.ncbi.nlm.nih.gov/24675767
https://pubmed.ncbi.nlm.nih.gov/24675767