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Akademický článek

Investigation of the Possible Pharmacologically Active Forms of the Nicotinic Acetylcholine Receptor Agonist Anabaseine

Autor: Kristin Andrud, Hong Xing, Bjarne Gabrielsen, Linda Bloom, Vladimir Mahnir, Stephen Lee, Benedict T. Green, Jon Lindstrom, William Kem

Publikováno v: Marine Drugs, Vol 17, Iss 11, p 614 (2019)

Three major forms of the nicotinic agonist toxin anabaseine (cyclic iminium, cyclic imine and the monocationic open-chain ammonium-ketone) co-exist in almost equal concentrations at physiological pH. We asked the question: Which of these forms is pha

Externí odkaz: https://doaj.org/article/b7c84c2e21d741a98204f26dc3caed1b

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Interactions of Nereistoxin and Its Analogs with Vertebrate Nicotinic Acetylcholine Receptors and Molluscan ACh Binding Proteins

Autor: William Kem, Kristin Andrud, Galen Bruno, Hong Xing, Ferenc Soti, Todd Talley, Palmer Taylor

Publikováno v: Marine Drugs; Volume 20; Issue 1; Pages: 49
Marine Drugs, vol 20, iss 1
Marine Drugs, Vol 20, Iss 49, p 49 (2022)
Marine Drugs

Nereistoxin (NTX) is a marine toxin isolated from an annelid worm that lives along the coasts of Japan. Its insecticidal properties were discovered decades ago and this stimulated the development of a variety of insecticides such as Cartap that are r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6e979e20efcd237dcfadbd8fa457283

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Akademický článek

The Nemertine Toxin Anabaseine and Its Derivative DMXBA (GTS-21): Chemical and Pharmacological Properties

Autor: Hugo R. Arias, Kuo-Chen Chou, Dong-Qing Wei, Kelly MacDougall, Susan LeFrancois, Kristin Wildeboer, Ferenc Soti, William Kem

Publikováno v: Marine Drugs, Vol 4, Iss 3, Pp 255-273 (2006)

Abstract: Nemertines are a phylum of carnivorous marine worms that possess a variety of alkaloidal, peptidic or proteinaceous toxins that serve as chemical defenses against potential predators. The hoplonemertines additionally envenomate their prey w

Externí odkaz: https://doaj.org/article/351ffeb6adc34ab383c6ba58635f829d

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Review

Nobuhiro Fusetani and William Kem (Eds.): Marine toxins as research tools.

Autor: Botana, Luis M.¹ luis.botana@usc.es

Publikováno v: Analytical & Bioanalytical Chemistry. Dec2009, Vol. 395 Issue 7, p1943-1944. 2p. 1 Color Photograph.

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Marine toxins: an overview

Autor: Nobuhiro, Fusetani, William, Kem

Publikováno v: Progress in molecular and subcellular biology. 46

Oceans provide enormous and diverse space for marine life. Invertebrates are conspicuous inhabitants in certain zones such as the intertidal; many are soft-bodied, relatively immobile and lack obvious physical defenses. These animals frequently have

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::043612acf36eaba48432f4e28fe69f48
https://pubmed.ncbi.nlm.nih.gov/19184583

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Marine Toxins as Research Tools

Autor: Nobuhiro Fusetani, William Kem

Publikováno v: Progress in Molecular and Subcellular Biology ISBN: 9783540878926
Marine Toxins as Research Tools

Marine Toxins: An Overview.- Conotoxins: Molecular and Therapeutic Targets.- Sodium Channel Inhibiting Marine Toxins.- Sea Anemone Toxins Affecting Potassium Channels.- Ligands for Ionotropic Glutamate Receptors.- Marine Toxins Potently Affecting Neu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::18270486d695bedb46635153447f1422
https://doi.org/10.1007/978-3-540-87895-7