Zobrazeno 1 - 10
of 72
pro vyhledávání: '"William Ka Kei Wu"'
Autor:
Huarong Chen, Weixin Liu, Olabisi Oluwabukola Coker, Na Qin, Hongyan Chen, Yifei Wang, Xiaodong Liu, Lin Zhang, Gordon Y.S. Choi, Wai Tat Wong, Czarina C.H. Leung, Lowell Ling, Mamie Hui, Tony Gin, Sunny Hei Wong, Matthew Tak Vai Chan, William Ka Kei Wu
Publikováno v:
Heliyon, Vol 10, Iss 8, Pp e29572- (2024)
Sepsis is a life-threatening illness caused by the dysregulated host response to infection. Nevertheless, our current knowledge of the microbial landscape in the blood of septic patients is still limited. Next-generation sequencing (NGS) is a sensiti
Externí odkaz:
https://doaj.org/article/40a38ee7d9394702a79e74e2ab959e34
Autor:
Wei Hu, Zhi Yong Zhai, Zhao Yu Huang, Ze Min Chen, Ping Zhou, Xia Xi Li, Gen Hua Yang, Chong Ju Bao, Li Juan You, Xiao Bing Cui, Gui Li Xia, Mei Ping Ou Yang, Lin Zhang, William Ka Kei Wu, Long Fei Li, Yu Xuan Zhang, Zhan Gang Xiao, Wei Gong
Publikováno v:
mSystems, Vol 9, Iss 4 (2024)
ABSTRACTHelicobacter pylori is a highly successful pathogen that poses a substantial threat to human health. However, the dynamic interaction between H. pylori and the human gastric epithelium has not been fully investigated. In this study, using dua
Externí odkaz:
https://doaj.org/article/26dda7bc403f4919aba38c82d6144312
Autor:
Olabisi Oluwabukola Coker, Changan Liu, William Ka Kei Wu, Sunny Hei Wong, Wei Jia, Joseph J. Y. Sung, Jun Yu
Publikováno v:
Microbiome, Vol 10, Iss 1, Pp 1-12 (2022)
Abstract Background Gut microbiota contributes to colorectal cancer (CRC) pathogenesis through microbes and their metabolites. The importance of microbiota-associated metabolites in colorectal carcinogenesis highlights the need to investigate the gut
Externí odkaz:
https://doaj.org/article/4c763cd060fe4c17a461972325dfe75a
Autor:
Xiaoxuan Xia, Yexian Zhang, Rui Sun, Yingying Wei, Qi Li, Marc Ka Chun Chong, William Ka Kei Wu, Benny Chung-Ying Zee, Hua Tang, Maggie Haitian Wang
Publikováno v:
PLoS Genetics, Vol 18, Iss 10, p e1010443 (2022)
Multi-population cohorts offer unprecedented opportunities for profiling disease risk in large samples, however, heterogeneous risk effects underlying complex traits across populations make integrative prediction challenging. In this study, we propos
Externí odkaz:
https://doaj.org/article/4b6ab098b18f487a892fbfc60d539e65
Autor:
Jiandong Zhou, Sharen Lee, Xiansong Wang, Yi Li, William Ka Kei Wu, Tong Liu, Zhidong Cao, Daniel Dajun Zeng, Keith Sai Kit Leung, Abraham Ka Chung Wai, Ian Chi Kei Wong, Bernard Man Yung Cheung, Qingpeng Zhang, Gary Tse
Publikováno v:
npj Digital Medicine, Vol 4, Iss 1, Pp 1-9 (2021)
Abstract Recent studies have reported numerous predictors for adverse outcomes in COVID-19 disease. However, there have been few simple clinical risk scores available for prompt risk stratification. The objective is to develop a simple risk score for
Externí odkaz:
https://doaj.org/article/9bbff64d31ad4c4d921fa169b2fe5fc7
Autor:
Xiaoxuan Xia, William Ka Kei Wu, Sunny Hei Wong, Dabin Liu, Thomas Ngai Yeung Kwong, Geicho Nakatsu, Pearlly S. Yan, Yu-Ming Chuang, Michael Wing-Yan Chan, Olabisi Oluwabukola Coker, Zigui Chen, Yun Kit Yeoh, Liuyang Zhao, Xiansong Wang, Wing Yin Cheng, Matthew Tak Vai Chan, Paul Kay Sheung Chan, Joseph Jao Yiu Sung, Maggie Haitian Wang, Jun Yu
Publikováno v:
Microbiome, Vol 8, Iss 1, Pp 1-13 (2020)
Abstract Background Altered microbiome composition and aberrant promoter hypermethylation of tumor suppressor genes (TSGs) are two important hallmarks of colorectal cancer (CRC). Here we performed concurrent 16S rRNA gene sequencing and methyl-CpG bi
Externí odkaz:
https://doaj.org/article/48ee2fc5625d4486a4c1566784db8387
Autor:
Ruifu Sun, Xuesong Wang, Xiaohong Sun, Bing Zhao, Xiugong Zhang, Xiaojin Gong, Sunny Hei Wong, Matthew Tak Vai Chan, William Ka Kei Wu
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Ankylosing spondylitis (AS) is a chronic systemic autoimmune disease characterized by inflammation, bone erosion, spur formation of the spine and the sacroiliac joints. However, the etiology and molecular pathogenesis of AS remain largely unclear. Re
Externí odkaz:
https://doaj.org/article/8b4cf2d55b8f4b4ea13c4d01de90e4db
Autor:
Rui Sun, Xiaoxuan Xia, Ka Chun Chong, Benny Chung-Ying Zee, William Ka Kei Wu, Maggie Haitian Wang
Publikováno v:
BMC Medical Genomics, Vol 12, Iss S9, Pp 1-6 (2019)
Abstract Background With the increasing amount of high-throughput genomic sequencing data, there is a growing demand for a robust and flexible tool to perform interaction analysis. The identification of SNP-SNP, SNP-CpG, and higher order interactions
Externí odkaz:
https://doaj.org/article/9dde0bc821bb498cbe39786792e851d5
Autor:
William Ka Kei Wu, Gary Tse, Ian Chi Kei Wong, Qingpeng Zhang, Jiandong Zhou, Sharen Lee, Keith Sai Kit Leung, Kamalan Jeevaratnam, Wing Tak Wong
Publikováno v:
BMJ Open Diabetes Research & Care, Vol 9, Iss 1 (2021)
Introduction Patients with diabetes mellitus are risk of premature death. In this study, we developed a machine learning-driven predictive risk model for all-cause mortality among patients with type 2 diabetes mellitus using multiparametric approach
Externí odkaz:
https://doaj.org/article/d6512d43e4874e27a8421814a2b7f438
Autor:
Xiaoting Zhang, Hao Su, Hongyan Chen, Qing Li, Xiaodong Liu, Lin Zhang, William Ka Kei Wu, Matthew Tak Vai Chan, Huarong Chen
Publikováno v:
Biomedicines, Vol 10, Iss 8, p 1918 (2022)
Gastrointestinal (GI) cancer, referring to cancers of the digestive system such as colorectal cancer (CRC), gastric cancer (GC), and liver cancer, is a major cause of cancer-related deaths in the world. A series of genetic, epigenetic, and epitranscr
Externí odkaz:
https://doaj.org/article/7c31203688dd4c39ab7db78e121e176a