Zobrazeno 1 - 10
of 18
pro vyhledávání: '"William K. Nichols"'
Autor:
Garold S. Yost, Tyler A. Moss, Judith C. Chow, John C. Walton, William K. Nichols, John M. Veranth, Raed Labban, John G. Watson
Publikováno v:
Environmental Health Perspectives
We treated human lung epithelial cells, type BEAS-2B, with 10-80 microg/cm2 of dust from soils and road surfaces in the western United States that contained particulate matter (PM)2.5 microm aerodynamic diameter. Cell viability and cytokine secretion
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd9ea8ff1f2335df7acdba989fe591b0
https://doi.org/10.1289/ehp.8360
https://doi.org/10.1289/ehp.8360
Publikováno v:
Toxicology and Applied Pharmacology. 122:182-190
3-Methylindole (3MI), a fermentation product of tryptophan produced by intestinal and ruminal microflora, has been shown to cause pneumotoxicity in several species subsequent to cytochrome P450-mediated biotransformation. Among several species studie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95af099c6d034a065de577a2ba226cfd
https://doi.org/10.1006/taap.1993.1186
https://doi.org/10.1006/taap.1993.1186
Autor:
Garold S. Yost, William K. Nichols, Mark O. Covington, Shaheen Safiullah, Christopher D. Seiders
Publikováno v:
Pharmacology & Toxicology. 71:335-339
I,1-Dichloro-2,2-bis (4′-chlororphenyl)ethane (DDD), 1,2-dibromoethane (DBE) and trichloroethylene are three halogenated hydrocarbons that selectively bind to pulmonary epithelial cells and that may be pneumotoxic. The susceptibility of pulmonary c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1b2087b024729ab4b38afde20fa7f9c
https://doi.org/10.1111/j.1600-0773.1992.tb00557.x
https://doi.org/10.1111/j.1600-0773.1992.tb00557.x
Autor:
William K. Nichols, Jessica M. Weems, Garold S. Yost, John G. Lamb, David Martin, Chad D. Moore, Evan Makin, Ned. S. Cutler
Previous work has shown that bioactivation of the cigarette smoke pneumotoxicant 3-methylindole (3MI) by pulmonary cytochrome P450 enzymes is directly associated with formation of DNA adducts. Here, we present evidence that normal human lung epitheli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a3431714a3ea97839b531465b1849a8
https://europepmc.org/articles/PMC2769061/
https://europepmc.org/articles/PMC2769061/
Publikováno v:
Advances in Experimental Medicine and Biology ISBN: 9781468458794
3-Methylindole (3MI) is constitutively produced by anaerobic bacterial fermentation of tryptophan in mammalian intestines. In the case of ruminants excessive 3MI production causes selective pulmonary toxicity which can be fatal (Carlson and Yost, 198
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a9ecdcf7ed66e033ac892733aa191b61
https://doi.org/10.1007/978-1-4684-5877-0_24
https://doi.org/10.1007/978-1-4684-5877-0_24
Publikováno v:
Toxicology and applied pharmacology. 105(2)
3-Methylindole (3MI) is a pneumotoxin that causes selective lung lesions indicative of Clara cell and alveolar epithelial cell damage in ruminants and rodents. The present study examined the cytotoxicity of 3MI to isolated rabbit Clara cells, type II
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d129e2f19efba1987b239f4bc600d894
https://pubmed.ncbi.nlm.nih.gov/2219119
https://pubmed.ncbi.nlm.nih.gov/2219119
Publikováno v:
Collagen and Related Research. 6:505-514
Cartilage-derived growth factor (CDGF), a protein closely related to basic fibroblast growth factor, is known to have both mitogenic and chemokinetic properties in microvascular endothelial cells (MVEC). Becaue of the angiogenic properties of CDGF an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7792778a416a14c8012b34daea2d13a0
https://doi.org/10.1016/s0174-173x(87)80049-3
https://doi.org/10.1016/s0174-173x(87)80049-3
Publikováno v:
Life Sciences. 27:913-920
Lipopolysaccharide from E. Coli (LPS) and BCG cell walls (BCGcw) are recognized immunoadjuvants that directly stimulate some macrophage functions. The macrophage cell line J774.1 and peritoneal exudate cells (PEC) from mice can be stimulated by LPS o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0dd8da9fbce649b91da6ee7b3ee0319c
https://doi.org/10.1016/0024-3205(80)90100-9
https://doi.org/10.1016/0024-3205(80)90100-9
Publikováno v:
Diabetologia. 16:51-57
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af13f38c5f426cb0baf020ab9cf8bff6
https://doi.org/10.1007/bf00423151
https://doi.org/10.1007/bf00423151
Publikováno v:
The Journal of Immunology. 119:450-456
Two classes of agents have effects on the chemotactic response of human neutrophils. Chemoattractants such as activated complement components, E. coli culture filtrates (BF) and the recently discovered N-formylmethionyl peptides, initiate directed mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::311da17aea3db70c2343b5b6ccd3184f
https://doi.org/10.4049/jimmunol.119.2.450
https://doi.org/10.4049/jimmunol.119.2.450