Zobrazeno 1 - 10
of 10
pro vyhledávání: '"William K. Love"'
Autor:
Lucy G. Andrews, Santosh K. Katiyar, Trygve O. Tollefsbol, William K. Love, Joel B. Berletch, Can-hui Liu
Publikováno v:
Journal of Cellular Biochemistry. 103:509-519
The ends of human chromosomes are protected from the degradation associated with cell division by 15-20 kb long segments of hexameric repeats of 5′-TTAGGG-3′ termed telomeres. In normal cells telomeres lose up to 300 bp of DNA per cell division t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2708207417aa6090afaccc6bbcebf322
https://doi.org/10.1002/jcb.21417
https://doi.org/10.1002/jcb.21417
Publikováno v:
Current Medicinal Chemistry. 13:2875-2888
Current standard cancer therapies (chemotherapy and radiation) often cause serious adverse off-target effects. Drug design strategies are therefore being developed that will more precisely target cancer cells for destruction while leaving surrounding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::608c9d054110be32416d6f7b4c9e03d6
https://doi.org/10.2174/092986706778521887
https://doi.org/10.2174/092986706778521887
Publikováno v:
Anticancer research. 29(12)
Multiple mechanisms regulate cancer-associated telomerase activity at the level of human telomerase reverse transcriptase (hTERT) transcription which may serve as novel targets for anticancer approaches.The effects of prolonged all-trans retinoic aci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7fed79665d3f9b8b5ae5708c559805b9
https://pubmed.ncbi.nlm.nih.gov/20044602
https://pubmed.ncbi.nlm.nih.gov/20044602
Although the progression of aging and the diseases associated with it are extensively studied, little is known about the initiation of the aging process. Telomerase is down-regulated early in embryonic differentiation, thereby contributing to telomer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe879393aaad51a3757fd7d1a4af8049
https://europepmc.org/articles/PMC2629501/
https://europepmc.org/articles/PMC2629501/
Autor:
Joel B. Berletch, Lucy G. Andrews, Wayne J. Brouillette, J. Tyson DeAngelis, William K. Love, Trygve O. Tollefsbol, Donald D. Muccio, Sharla M. O. Phipps
Publikováno v:
Translational oncology. 1(3)
Telomerase, a ribonucleoprotein important to neoplastic immortality, is up-regulated in approximately 85% of cancers, including leukemias. In this study, 9cUAB30, a novel retinoic acid, resulted in differentiation of HL60 leukemia cells as indicated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba28a1e7848b8d2c6a46b962c6575961
https://pubmed.ncbi.nlm.nih.gov/18795149
https://pubmed.ncbi.nlm.nih.gov/18795149
Publikováno v:
International Journal of Oncology.
Changes in the promoter methylation of hTERT, the gene that encodes telomerase, a ribonucleoprotein responsible for replacing telomeric repeats, have been demonstrated in differentiating cells where hTERT is inhibited, suggesting epigenetic regulatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d177410ae970329da57ae906afdc54cc
https://doi.org/10.3892/ijo.32.3.625
https://doi.org/10.3892/ijo.32.3.625
Publikováno v:
International journal of oncology. 32(3)
Changes in the promoter methylation of hTERT, the gene that encodes telomerase, a ribonucleoprotein responsible for replacing telomeric repeats, have been demonstrated in differentiating cells where hTERT is inhibited, suggesting epigenetic regulatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::718bf30f0a706effbc072e86c1aca558
https://pubmed.ncbi.nlm.nih.gov/18292940
https://pubmed.ncbi.nlm.nih.gov/18292940
Autor:
Nathan J. Hansen, Trygve O. Tollefsbol, William K. Love, Sharla M. O. Phipps, Rebecca C. Wylie, Lucy G. Andrews
Publikováno v:
International Journal of Oncology.
Retinoic acids and their derivatives potentiate anti-cancer effects in breast cancer cells. The aberrant expression of telomerase is critical to the continued proliferation of most cancer cells. Thus, telomerase is an attractive target for chemo-prev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::73666e70d3753df6c8741d69789cdc0b
https://doi.org/10.3892/ijo.30.3.641
https://doi.org/10.3892/ijo.30.3.641
Autor:
Nathan J, Hansen, Rebecca C, Wylie, Sharla M O, Phipps, William K, Love, Lucy G, Andrews, Trygve O, Tollefsbol
Publikováno v:
International journal of oncology. 30(3)
Retinoic acids and their derivatives potentiate anti-cancer effects in breast cancer cells. The aberrant expression of telomerase is critical to the continued proliferation of most cancer cells. Thus, telomerase is an attractive target for chemo-prev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2d3a3fc14a60adfce3f2997358f1ace9
https://pubmed.ncbi.nlm.nih.gov/17273765
https://pubmed.ncbi.nlm.nih.gov/17273765
Autor:
Michael A. Cawthon, John M. Bauman, William K. Love, Robert D. Karl, William H. Howard, Michael F. Hartshorne, Stephen R. Bunker
Publikováno v:
Clinical Nuclear Medicine. 9:P9
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::448ad6d1911ca8254415c0343240d7fe
https://doi.org/10.1097/00003072-198403001-00004
https://doi.org/10.1097/00003072-198403001-00004