Zobrazeno 1 - 10
of 48
pro vyhledávání: '"William K Schmidt"'
Autor:
William K. Schmidt, Irene Cortés‐Puch, Cindy B. McReynolds, Glenn E. Croston, Sung Hee Hwang, Jun Yang, Theresa L. Pedersen, Karen M. Wagner, Theresa T. Pham, Thomas Hunt, Bruce D. Hammock
Publikováno v:
Clinical and Translational Science, Vol 17, Iss 9, Pp n/a-n/a (2024)
Abstract Chronic pain represents a significant unmet medical need, affecting one‐fifth of the U.S. population. EC5026 is a small molecule inhibitor of the enzyme soluble epoxide hydrolase (sEH) which is being developed as a novel non‐opioid, non
Externí odkaz:
https://doaj.org/article/d23ba464802241f69df3a0fdd283dc0d
Autor:
D. Lynn Kirkpatrick, Cari Evans, Linda A. Pestano, Jeffrey Millard, Matthew Johnston, Emily Mick, William K. Schmidt
Publikováno v:
Clinical and Translational Science, Vol 17, Iss 3, Pp n/a-n/a (2024)
Abstract PF614, a trypsin‐activated abuse protection oxycodone prodrug designed to reduce recreational drug abuse, was compared to OxyContin for safety and pharmacokinetics (PKs) of plasma oxycodone following oral administration. This study was a t
Externí odkaz:
https://doaj.org/article/ff177eccb53f41dfa9ae01919fad64a1
Autor:
Cindy B. McReynolds, Sung Hee Hwang, Jun Yang, Debin Wan, Karen Wagner, Christophe Morisseau, Dongyang Li, William K. Schmidt, Bruce D. Hammock
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
Osteoarthritis (OA) is a degenerative joint disease that causes pain and bone deterioration driven by an increase in prostaglandins (PGs) and inflammatory cytokines. Current treatments focus on inhibiting prostaglandin production, a pro-inflammatory
Externí odkaz:
https://doaj.org/article/dac2eddca3cf4d3aa41cd147550a0d8f
Autor:
Bruce D. Hammock, Jun Yang, Cindy B. McReynolds, Irene Cortés-Puch, Karen Wagner, Glenn Croston, Sung Hee Hwang, Kin Sing Stephen Lee, Alan R. Buckpitt, William K. Schmidt
Publikováno v:
J Med Chem
[Image: see text] This report describes the development of an orally active analgesic that resolves inflammation and neuropathic pain without the addictive potential of opioids. EC5026 acts on the cytochrome P450 branch of the arachidonate cascade to
Autor:
William K Schmidt, Lynn R. Webster
Publikováno v:
Pain Medicine. 21:992-1004
Objective Although mu-opioid receptor agonists have been the mainstay of analgesic regimens for moderate to severe pain, they are associated with serious side effects, risks, and limitations. We evaluate the most serious risks associated with convent
Autor:
Laurie VanderVeen, Yi Liu, Frank Porreca, Caroline M. Kopruszinski, William K. Schmidt, Juliana Swiokla, Takahiro Miyazaki, Edita Navratilova, Miao Yang, Yeon Sun Lee, Jonathan Zalevsky
Publikováno v:
Cellular and molecular neurobiology. 41(5)
Pharmacological evaluation of the mu-opioid receptor (MOR) agonist properties of NKTR-181 in rodent models. Graded noxious stimulus intensities were used in rats to establish the antinociceptive potency and efficacy of NKTR-181 relative to morphine,
Publikováno v:
Pharmacology & Therapeutics. 180:62-76
Eicosanoids are biologically active lipid signaling molecules derived from polyunsaturated fatty acids. Many of the actions of eicosanoid metabolites formed by cyclooxygenase and lipoxygenase enzymes have been characterized, however, the epoxy-fatty
Autor:
Joseph V. Pergolizzi, William K. Schmidt, Gianpietro Zampogna, Jo Ann LeQuang, Robert Colucci, Frank Breve, Robert B. Raffa
Publikováno v:
Pain Practice. 16:794-808
Autor:
James N. Campbell, Eric Diamond, Robert R. Allen, Margaret Kelly, William Houghton, Kerrie L. Brady, Claudia M. Campbell, William K. Schmidt
Publikováno v:
Pain. 157:1297-1304
Intermetatarsal neuroma or Morton's neuroma is a painful condition of the foot resulting from an entrapment of the common digital nerve typically in the third intermetatarsal space. The pain can be severe and especially problematic with walking. Trea
Autor:
Bruce D. Hammock, Sung Hee Hwang, William K. Schmidt, Karen Wagner, Cindy B. McReynolds, Jun Yang
Publikováno v:
The FASEB Journal. 32