Zobrazeno 1 - 7
of 7
pro vyhledávání: '"William Jay Moore"'
Autor:
Darlene C. Deecher, Puwen Zhang, An T. Vu, Jenifer A. Bray, Rebecca Dooley, Stephen Todd Cohn, Igor Goljer, Paige Erin Mahaney, Grace H. Johnston, Jennifer Leiter, Terefenko Eugene Anthony, Eugene John Trybulski, William Jay Moore
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:2464-2467
A series of 3-(arylamino)-3-phenylpropan-2-olamines was prepared and screened for their ability to inhibit monoamine reuptake. A number of analogues displayed significant dual norepinephrine and serotonin reuptake inhibition. Compounds in this class
Autor:
Robert John Steffan, Lydia Mosyak, Richard C. Winneker, Susan Chippari, Lisa Borges-Marcucci, Amy Eckert, William Jay Moore, Zhang Xu, Edward Martin Matelan, Christopher C. Chadwick, Mark A. Ashwell, William Ronald Solvibile, Steven J. Adelman, Thomas Kenney, Eugene John Trybulski, Douglas C. Harnish
Publikováno v:
Current Topics in Medicinal Chemistry. 6:103-111
The discovery of novel intervention points in the inflammatory pathway has been a focus of drug development in recent years. We have identified pathway selective ligands for the estrogen receptor (ER) that inhibit NF-kappaB mediated inflammatory gene
Autor:
Jeffrey Curtis Kern, Ronald L. Magolda, Shoichi Fukyama, Girija Krishnamurthy, Eugene John Trybulski, Barb Stauffer, William Jay Moore, Peter V.N. Bodine, Keith Pitts, Ramesh A. Bhat
Publikováno v:
Bioorganicmedicinal chemistry. 18(1)
Piperidinyl diphenylsulfonyl sulfonamides are a novel class of molecules that have inhibitory binding affinity for sFRP-1. As a secreted protein sFRP-1 inhibits the function of the secreted Wnt glycoprotein. Therefore, as inhibitors of sFRP-1 these s
Autor:
Jeffrey Curtis Kern, Peter V.N. Bodine, Shoichi Fukayama, Gregory S. Welmaker, Girija Krishnamurthy, Thomas Joseph Commons, Lisa Nogle, William Jay Moore, Ramesh A. Bhat, Keith Pitts, Eugene John Trybulski, Barb Stauffer, Wilson Matthew Allan, Igor Goljer, Ronald L. Magolda
Publikováno v:
Journal of medicinal chemistry. 52(1)
The diphenylsulfonyl sulfonamide scaffold represented by 1 (WAY-316606) are small molecule inhibitors of the secreted protein sFRP-1, an endogenous antagonist of the secreted glycoprotein Wnt. Modulators of the Wnt pathway have been proposed as anabo
Autor:
Jeffrey Curtis Kern, Shoichi Fukayama, Gregory S. Welmaker, Mengxiao Shi, Thomas Joseph Commons, Richard Page Woodworth, Barry S. Komm, Robert A. Moran, Girija Krishnamurthy, Wilson Matthew Allan, Ramesh A. Bhat, Annamarie Mangine, Peter V.N. Bodine, Laura M. Seestaller-Wehr, William Jay Moore, Keith Pitts, Eugene John Trybulski, Barbara Stauffer, Julia Billiard, Ariamala Gopalsamy, Helga Ponce-de-Leon
Publikováno v:
Bone. 44(6)
Canonical Wnt signaling has been demonstrated to increase bone formation, and Wnt pathway components are being pursued as potential drug targets for osteoporosis and other metabolic bone diseases. Deletion of the Wnt antagonist secreted frizzled-rela
Autor:
Peimin Lu, David S. Casebier, Dennis Kubrak, S. Aschmies, David Riddell, William Jay Moore, Zheng Wang, Mei Jin, Hua Zhou, Thomas A. Comery, John W. Ellingboe, Shaiu-Ching Sun, Erik Wagner, Aram Oganesian, Joseph Raymond Stock, Boyd L. Harrison, Zheng Xu, Robert Martone, George Diamantidis, Madelene Antane, Kevin Atchison, Kevin R. Woller, Yun Hu, June Sonnenberg-Reines, Charles William Mann, J. Steven Jacobsen, Anthony F. Kreft, Derek C. Cole
Publikováno v:
Bioorganicmedicinal chemistry letters. 19(3)
Accumulation of beta-amyloid (Abeta), produced by the proteolytic cleavage of amyloid precursor protein (APP) by beta- and gamma-secretase, is widely believed to be associated with Alzheimer's disease (AD). Research around the high-throughput screeni
Autor:
Andrea Olland, Jonathan A. Bard, Steve Jacobsen, John W. Ellingboe, Rebecca Cowling, Mary-Margaret O’Donnell, Junjun Wu, Joseph Raymond Stock, Kristine Svenson, Rajiv Chopra, Eric Wagner, Eric S. Manas, Lee D. Jennings, Michael S. Malamas, Robichaud Albert Jean, Yun Hu, Boyd L. Harrison, Kristi Fan, Derek C. Cole, William Jay Moore, Guixian Jin, Peter A. Lohse
Publikováno v:
Bioorganicmedicinal chemistry letters. 18(3)
Proteolytic cleavage of amyloid precursor protein by beta-secretase (BACE-1) and gamma-secretase leads to formation of beta-amyloid (A beta) a key component of amyloid plaques, which are considered the hallmark of Alzheimer's disease. Small molecule