Zobrazeno 1 - 10
of 18
pro vyhledávání: '"William J. Zamora"'
Autor:
Jazmín Miranda-Salas, Carlos Peña-Varas, Ignacio Valenzuela Martínez, Dionisio A. Olmedo, William J. Zamora, Miguel Angel Chávez-Fumagalli, Daniela Q. Azevedo, Rachel Oliveira Castilho, Vinicius G. Maltarollo, David Ramírez, José L. Medina-Franco
Publikováno v:
Artificial Intelligence in the Life Sciences, Vol 3, Iss , Pp 100077- (2023)
Chemoinformatics is an independent inter-discipline with a broad impact in drug design and discovery, medicinal chemistry, biochemistry, analytical and organic chemistry, natural products, and several other areas in chemistry. Through collaborations,
Externí odkaz:
https://doaj.org/article/05925ea4425241b68ebe272ec07cdb19
Autor:
Alejandro Gómez-García, Daniel A. Acuña Jiménez, William J. Zamora, Haruna L. Barazorda-Ccahuana, Miguel Á. Chávez-Fumagalli, Marilia Valli, Adriano D. Andricopulo, Vanderlan da S. Bolzani, Dionisio A. Olmedo, Pablo N. Solís, Marvin J. Núñez, Johny R. Rodríguez Pérez, Hoover A. Valencia Sánchez, Héctor F. Cortés Hernández, José L. Medina-Franco
Publikováno v:
Pharmaceuticals, Vol 16, Iss 10, p 1388 (2023)
The number of databases of natural products (NPs) has increased substantially. Latin America is extraordinarily rich in biodiversity, enabling the identification of novel NPs, which has encouraged both the development of databases and the implementat
Externí odkaz:
https://doaj.org/article/a79876af93284f3a850bb4773f0b49fc
Autor:
Jéssica de O. Araújo, Silvana Pinheiro, William J. Zamora, Cláudio Nahum Alves, Jerônimo Lameira, Anderson H. Lima
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract In SARS-CoV-2 replication complex, the Non-structural protein 9 (Nsp9) is an important RNA binding subunit in the RNA-synthesizing machinery. The dimeric forms of coronavirus Nsp9 increase their nucleic acid binding affinity and the N-finger
Externí odkaz:
https://doaj.org/article/7731929feb7a485ab9773988c13d99ca
Publikováno v:
Antibiotics, Vol 12, Iss 3, p 550 (2023)
Antibiotic resistance (ABR) has direct and indirect repercussions on public health and threatens to decrease the therapeutic effect of antibiotic treatments and lead to more infection-related deaths. There are several mechanisms by which ABR can be t
Externí odkaz:
https://doaj.org/article/d5de8365bba64e4394d39bae447ddb8a
Autor:
William J. Zamora Ramírez, Esteban Bertsch Aguilar, Sebastián Suñer Sánchez, Silvana Pinheiro
Lipophilicity is a physicochemical property with wide relevance in drug design and also applied in areas such as food chemistry, environmental chemistry, and computational biology. This descriptor strongly influences the absorption, distribution, per
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::16a848f659dc53759269800a03dc4723
https://doi.org/10.26434/chemrxiv-2023-54gv8
https://doi.org/10.26434/chemrxiv-2023-54gv8
Autor:
William J. Zamora Ramírez, Antonio Viayna, Silvana Pinheiro, Carles Curutchet, Laia Bisbal, Rebeca Ruiz, Clara Ràfols, F. Javier Luque
In recent years the use of partition systems other than the widely used biphasic n-octanol/water has received increased attention to gain insight into the molecular features that dictate the lipophilicity of compounds. Thus, the difference between n-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::615523e9e6edf1ac3912dcc7dea42355
https://doi.org/10.26434/chemrxiv-2023-fg64s
https://doi.org/10.26434/chemrxiv-2023-fg64s
Autor:
Jerônimo Lameira, Jéssica de O. Araújo, Anderson Henrique Lima e Lima, Silvana Pinheiro, Cláudio Nahum Alves, William J. Zamora
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Scientific Reports
Scientific Reports
In SARS-CoV-2 replication complex, the Non-structural protein 9 (Nsp9) is an important RNA binding subunit in the RNA-synthesizing machinery. The dimeric forms of coronavirus Nsp9 increase their nucleic acid binding affinity and the N-finger motif ap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b21aecec8669a3847d45cf9c3a05d822
https://doaj.org/article/7731929feb7a485ab9773988c13d99ca
https://doaj.org/article/7731929feb7a485ab9773988c13d99ca
Publikováno v:
Journal of Computer-Aided Molecular Design
A multiple linear regression model called MLR-3 is used for predicting the experimental n-octanol/water partition coefficient (log PN) of 22 N-sulfonamides proposed by the organizers of the SAMPL7 blind challenge. The MLR-3 method was trained with 82
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f83bd9d9004dcacf93bcfa2894bb9064
https://doi.org/10.1007/s10822-021-00409-2
https://doi.org/10.1007/s10822-021-00409-2
Publikováno v:
Biophysical Journal. 122:142a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::480c82c1868b8897f27484f222a33435
https://doi.org/10.1016/j.bpj.2022.11.930
https://doi.org/10.1016/j.bpj.2022.11.930