Zobrazeno 1 - 10
of 55
pro vyhledávání: '"William J. Wechter"'
Autor:
Kenneth Hensley, Paula Grammas, Ladan Hamdheydari, Elaine J. Benaksas, Charles A. Stewart, Shenyun Mou, Robert A. Floyd, William J. Wechter, Quentin N. Pye
Publikováno v:
Biochemical and Biophysical Research Communications. 319:1047-1052
Our objective was to assess the anti-inflammatory effects of alpha-tocopherol, gamma-tocopherol, and their metabolites 2,5,7,8-tetramethyl-2-(beta-carboxyethyl)-6-hydroxychroman (alpha-CEHC) and 2,7,8-trimethyl-2-(beta-carboxyethyl)-6-hydroxychroman
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::968bcf33131d74911aa66538799ed0f4
https://doi.org/10.1016/j.bbrc.2004.05.082
https://doi.org/10.1016/j.bbrc.2004.05.082
Autor:
William J. Wechter, Kelly S. Williamson, Elaine J. Benaksas, Paula Grammas, Roberto Bolli, Ladan Hamdheydari, Kenneth Hensley, Marcus F. Stoddard, Melinda West, Robert A. Floyd, Gemma Wallis, Shenyun Mou, Quentin N. Pye
Publikováno v:
Free Radical Biology and Medicine. 36:1-15
Vitamin E (alpha-tocopherol or alphaT) has long been recognized as a classic free radical scavenging antioxidant whose deficiency impairs mammalian fertility. In actuality, alpha-tocopherol is one member of a class of phytochemicals that are distingu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36df89ae8a9f020807e60f24073857c5
https://doi.org/10.1016/j.freeradbiomed.2003.10.009
https://doi.org/10.1016/j.freeradbiomed.2003.10.009
Publikováno v:
Chirality. 16:379-387
Information about the potential and extent of bioinversion of chiral drugs in laboratory animal species and humans is critical to the interpretation of preclinical pharm-tox studies with these drugs. Unlike in the dog, guinea pig, and rabbit, in huma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9d496d995e62d75d0971c0b2170e6b9
https://doi.org/10.1002/chir.20053
https://doi.org/10.1002/chir.20053
Autor:
Vijendra K. Singh, Margaret E. Gnegy, S. P. Gupta, R. Leurs, R. C. Vollinga, H. Timmerman, Ray W. Fuller, Nissim Claude Cohen, Vincenzo Tschinke, Elaine J. Benaksas, E. David Murray, William J. Wechter, Indra Dwivedy, Suprabhat Ray
Volume 45 of'Progress in Drug Research'contains eight reviews and the various indexes which facilitate its use and establish the connection with the previous volumes. The articles in this volume deal with neuro peptides as native immune modulators,
Autor:
Karina M. Gibson, E. David Murray, John D. Mccracken, Darko Kantoci, Douglas D. Leipold, David D. Quiggle, William J. Wechter
Publikováno v:
Life Sciences. 66:745-753
Our previous studies with the mouse model of familial adenomatous polyposis (FAP), C57BL/6J-APCMin/+ or Min mouse, demonstrated the optimal dose for adenoma reduction with R-flurbiprofen was 10 mg/kg/day as an undivided dose. Divided doses exhibited
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::605a64167b043b8147ed3a169c7444de
https://doi.org/10.1016/s0024-3205(99)00645-1
https://doi.org/10.1016/s0024-3205(99)00645-1
Autor:
Ralph E. Cutler, Kay H. Clifford, Sooky Witchwoot, Steven C. Forland, William J. Wechter, R. Leslie Arnett
Publikováno v:
The Journal of Clinical Pharmacology. 36:546-553
Flurbiprofen, an arylpropionic acid (APA) class nonsteroidal antiinflammatory drug (NSAID), is commercially available only as the racemic mixture, although its pharmacologic effect has been credited primarily to the S isomer. In humans, the bioavaila
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94ce4b28047e27120670595aaf8b443c
https://doi.org/10.1002/j.1552-4604.1996.tb05044.x
https://doi.org/10.1002/j.1552-4604.1996.tb05044.x
Calculation of Inversion Half-Lives of Aryl Propionic Acid Class Nonsteroidal Antiinflammatory Drugs
Autor:
Darko Kantoci, William J. Wechter
Publikováno v:
The Journal of Clinical Pharmacology. 36:500-504
Although inversion of the R-enantiomers of the aryl propionic acid (APA) class of nonsteroidal antiinflammatory drugs (NSAIDs) in humans and other mammals has been known for more than 20 years, no satisfactory method has been developed for evaluating
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d7d21e32312d14599dc9c185c0d4dc3
https://doi.org/10.1002/j.1552-4604.1996.tb05039.x
https://doi.org/10.1002/j.1552-4604.1996.tb05039.x
Autor:
E. David Murray, Youjiang Liu, Darko Kantoci, Resa L. Chase, David D. Quiggle, William J. Wechter, John D. Mccracken, Yoshimitzu Mineyama
Publikováno v:
The Journal of Clinical Pharmacology. 36:540-545
Nonsteroidal antiinflammatory drugs (NSAIDs) are recognized for inhibiting growth of colon tumors in animal models, and for reducing the risk of colon cancer in humans. The mechanisms involved have not been established, but are thought to be related
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33b4c9759efa7d110e3291d2a1113e7d
https://doi.org/10.1002/j.1552-4604.1996.tb05043.x
https://doi.org/10.1002/j.1552-4604.1996.tb05043.x
Publikováno v:
Synthetic Communications. 26:2037-2043
A new facile synthesis of aminobisphosphonate was reported. Dibenzylamine bisphosphonate (1) is prepared from dibenzylamine, triethyl orthoformate and diethyl phosphite. Deprotection by hydrogen transfer reaction and acid hydrolysis afforded aminobis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::128276f0e4f6bbfc8deeda82e00c3ff4
https://doi.org/10.1080/00397919608003560
https://doi.org/10.1080/00397919608003560
Publikováno v:
Journal of Medicinal Chemistry. 39:1196-1200
In our search for endogenous natriuretic factors from human uremic urine, we have previously identified a new metabolite of the drug diltiazem (Murray et al. Life Sci. 1995, 57, 2145-2161). The structure of this metabolite, (+)-(2S,3S)-3-hydroxy-5-(2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aae7eff437cd1a65051255b2f4853f86
https://doi.org/10.1021/jm950559n
https://doi.org/10.1021/jm950559n