Zobrazeno 1 - 10
of 18
pro vyhledávání: '"William J. Stanley"'
Autor:
Sara A. Litwak, Jibran A. Wali, Evan G. Pappas, Hamdi Saadi, William J. Stanley, L. Chitra Varanasi, Thomas W. H. Kay, Helen E. Thomas, Esteban N. Gurzov
Publikováno v:
Journal of Diabetes Research, Vol 2015 (2015)
Pancreatic β-cell loss induced by saturated free fatty acids (FFAs) is believed to contribute to type 2 diabetes. Previous studies have shown induction of endoplasmic reticulum (ER) stress, increased ubiquitinated proteins, and deregulation of the B
Externí odkaz:
https://doaj.org/article/cc42862cb1e94bc789cf5a2f5e4bdf7c
Autor:
Esteban Nicolas Gurzov, William J Stanley, Maria Eriksson, Peter Thorn, Ulf Ahlgren, Yan Yun, Sara A Litwak
Publikováno v:
Molecular Pharmaceutics
Molecular pharmaceutics
Molecular pharmaceutics
Type 1 diabetes develops in childhood and adolescence, with peak incidence in the early teenage years. There is an urgent need for an accurate method to detect insulin-producing β-cells in patients that is not affected by alterations in β-cell func
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d5e1f10668bd27bd2743ea0e9423cbf
Autor:
Prerak Trivedi, William J Stanley, Helen E. Thomas, Andrew P Ap Sutherland, Esteban Nicolas Gurzov
Publikováno v:
Journal of Molecular Endocrinology. 59:325-337
Type 1 diabetes (T1D) is characterized by the destruction of insulin-producing β-cells by immune cells in the pancreas. Pro-inflammatory including TNF-α, IFN-γ and IL-1β are released in the islet during the autoimmune assault and signal in β-cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::645711cdf95c4aab1c811f0aca55f25f
https://doi.org/10.1530/jme-17-0089
https://doi.org/10.1530/jme-17-0089
Autor:
Emily H. Pilkington, Bo Wang, Marc-Antonie Sani, Michael Whittaker, Thomas P. Davis, Xinwei Ge, Feng Ding, May Lai, William J Stanley, Pu Chun Ke, John Jf Quinn, Aleksandr Kakinen, Esteban Nicolas Gurzov, Miaoyi Wang
Publikováno v:
Biomacromolecules
Protein aggregation into amyloid fibrils is a ubiquitous phenomenon across the spectrum of neurodegenerative disorders and type 2 diabetes. A common strategy against amyloidogenesis is to minimize the populations of toxic oligomers and protofibrils b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c0c9fe281e89412eafb64924900a6b0
http://europepmc.org/articles/PMC5729549
http://europepmc.org/articles/PMC5729549
Autor:
Lokman Pang, Decio L. Eizirik, Jean Valéry Turatsinze, Kim Loh, Mariana Igoillo-Esteve, Esteban Nicolas Gurzov, William J Stanley, Daniel J. Gough, Eric Trepo, Christophe Moreno, Sara A Litwak, Arpeeta Sharma, Sandra Galic, Helen E. Thomas, Judy B. de Haan
Publikováno v:
Diabetes. 66:2973-2986
The members of the BCL-2 family are crucial regulators of the mitochondrial pathway of apoptosis in normal physiology and disease. Besides their role in cell death, BCL-2 proteins have been implicated in the regulation of mitochondrial oxidative phos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cee18fa01548cdfd13bff33d750ef20
https://doi.org/10.2337/db17-0348
https://doi.org/10.2337/db17-0348
Autor:
Feng Ding, Pengyu Chen, Praveen Nedumpully-Govindan, Emily H. Pilkington, William J Stanley, Esteban Nicolas Gurzov, Sara A Litwak, Pu Chun Ke, Thomas P. Davis
Publikováno v:
Physical Chemistry Chemical Physics. 18:94-100
Human islet amyloid polypeptide (hIAPP or amylin) aggregation is directly associated with pancreatic β-cell death and subsequent insulin deficiency in type 2 diabetes (T2D). Since no cure is currently available for T2D, it is of great benefit to dev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c000b35648e4267d033fde0f08c36c7f
https://doi.org/10.1039/c5cp05924k
https://doi.org/10.1039/c5cp05924k
Autor:
Thomas P. Davis, William J Stanley, Emily H. Pilkington, Aleksandr Kakinen, Pu Chun Ke, Esteban Nicolas Gurzov, Sara A Litwak
Publikováno v:
Scientific Reports
Scientific reports, 6
Scientific reports, 6
Aggregation of human islet amyloid polypeptide (hIAPP) into fibrils and plaques is associated with pancreatic β-cell loss in type 2 diabetes (T2D). However, due to the rapidness of hIAPP conversion in aqueous phase, exactly which hIAPP species is re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4c50dc79658d06ec54dbc479241eab4
https://doi.org/10.1038/srep21274
https://doi.org/10.1038/srep21274
Autor:
Sara A Litwak, Kim Loh, Andreas Strasser, Esteban Nicolas Gurzov, Helen E. Thomas, Jibran A Wali, Claudia Selck, William J Stanley, Evan G Pappas
Publikováno v:
Scientific Reports
Scientific reports, 6
Scientific reports, 6
BCL-2 proteins have been implicated in the control of glucose homeostasis and metabolism in different cell types. Thus, the aim of this study was to determine the role of the pro-apoptotic BH3-only protein, p53-upregulated-modulator-of-apoptosis (PUM
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2636fb32454440ee72770afbd24bc074
https://pubmed.ncbi.nlm.nih.gov/27033313
https://pubmed.ncbi.nlm.nih.gov/27033313
Publikováno v:
The FEBS journal. 283(16)
Diabetes mellitus are complex, multi-organ metabolic pathologies characterized by hyperglycemia. Emerging evidence shows that the highly conserved and potent JAK/STAT signaling pathway is required for normal homeostasis, and, when dysregulated, contr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aaa120164c1ffc7a66c7e5e9e8fdab8c
https://pubmed.ncbi.nlm.nih.gov/26972840
https://pubmed.ncbi.nlm.nih.gov/26972840
Autor:
Thomas P. Davis, William J Stanley, Pu Chun Ke, Eric Hanssen, Aleksandr Kakinen, Sara A Litwak, Esteban Nicolas Gurzov, Pengyu Chen, Emily H. Pilkington, Feng Ding, Bo Wang
Publikováno v:
Small (Weinheim an der Bergstrasse, Germany). 12(12)
Human islet amyloid polypeptide (hIAPP, or amylin) forms amyloid deposits in the islets of Langerhans, a phenomenon that is associated with type-2 diabetes impacting millions of people worldwide. Accordingly, strategies against hIAPP aggregation are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20b70654c4d0582e621942eff599a05e
https://pubmed.ncbi.nlm.nih.gov/26808649
https://pubmed.ncbi.nlm.nih.gov/26808649