Zobrazeno 1 - 10
of 329
pro vyhledávání: '"William J. Ray"'
Autor:
Adrian Beckmann, Paulino Ramirez, Maria Gamez, Elias Gonzalez, Jasmine De Mange, Kevin F. Bieniek, William J. Ray, Bess Frost
Publikováno v:
iScience, Vol 26, Iss 3, Pp 106152- (2023)
Summary: In Alzheimer’s disease, neurons acquire phenotypes that are also present in various cancers, including aberrant activation of the cell cycle. Unlike cancer, cell cycle activation in post-mitotic neurons is sufficient to induce cell death.
Externí odkaz:
https://doaj.org/article/5965e057071d4ba79c8f4735a9a83cf8
Publikováno v:
Frontiers in Aging, Vol 4 (2023)
Neurodegenerative tauopathies, including Alzheimer’s disease, are pathologically defined by the presence of aggregated forms of tau protein in brains of affected individuals. Previous studies report that the negative effects of pathogenic tau on th
Externí odkaz:
https://doaj.org/article/660ed201abe5442da281023381a84c62
Publikováno v:
Frontiers in Aging Neuroscience, Vol 11 (2019)
APOE4 is the greatest genetic risk factor for late-onset Alzheimer’s disease (AD), increasing the risk of developing the disease by 3-fold in the 14% of the population that are carriers. Despite 25 years of research, the exact mechanisms underlying
Externí odkaz:
https://doaj.org/article/a8a2e43a65064e8b9f7048384400f0fa
Autor:
Sunil Goodwani, Celia Fernandez, Paul J. Acton, Virginie Buggia-Prevot, Morgan L. McReynolds, Jiacheng Ma, Cheng Hui Hu, Mary E. Hamby, Yongying Jiang, Kang Le, Michael J. Soth, Philip Jones, William J. Ray
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 14, p 4849 (2020)
Dual leucine zipper kinase (DLK, Map3k12) is an axonal protein that governs the balance between degeneration and regeneration through its downstream effectors c-jun N-terminal kinase (JNK) and phosphorylated c-jun (p-c-Jun). In peripheral nerves DLK
Externí odkaz:
https://doaj.org/article/0e5b22e2e4ed47cf94b6d8551ae1667c
Autor:
Sean Austin O. Lim, Rong Xia, Yunmin Ding, Lisa Won, William J. Ray, Stephen A. Hitchcock, Daniel S. McGehee, Un Jung Kang
Publikováno v:
Neurobiology of Disease, Vol 76, Iss , Pp 67-76 (2015)
Levodopa is the most effective therapy for the motor deficits of Parkinson's disease (PD), but long term treatment leads to the development of l-DOPA-induced dyskinesia (LID). Our previous studies indicate enhanced excitability of striatal cholinergi
Externí odkaz:
https://doaj.org/article/250b8769fd3246af8e7899fcd8c6a4bb
Autor:
Elizabeth Ochoa, Paulino Ramirez, Elias Gonzalez, Jasmine De Mange, William J. Ray, Kevin F. Bieniek, Bess Frost
Publikováno v:
Science advances. 9(1)
Deposition of tau protein aggregates in the brain of affected individuals is a defining feature of “tauopathies,” including Alzheimer’s disease. Studies of human brain tissue and various model systems of tauopathy report that toxic forms of tau
Autor:
Donavon McConn, Betty Lam, Victoria J Mulligan, Nicola Brice, Hans H Schiffer, Holger Monenschein, Stephen Hitchcock, Holly Reichard, Nidhi Kaushal, Deanna R Collia, Philip L R Gaskin, Jordi Serrats, Alejandro Amador-Arjona, William J. Ray, Jackie Cilia, Joshua Bliesath, Alton W Skaggs, Josephine Atienza, Gerard Corbett, Lisa Rahbaek
Publikováno v:
Journal of Medicinal Chemistry. 64:11527-11542
The orphan G-protein-coupled receptor GPR139 is highly expressed in the habenula, a small brain nucleus that has been linked to depression, schizophrenia (SCZ), and substance-use disorder. High-throughput screening and a medicinal chemistry structure
Autor:
Bo Peng, Virginie Buggia-Prevot, William J. Ray, Zhen Liu, Shelli R. Kesler, Iteeben D. Mahant, Paul Acton, Chaitali Chakraborty, Yongying Jiang, Kang Le, Faika Mseeh, Jiacheng Ma, Imran Jamal, Bruce L Roth, Annemieke Kavelaars, Cobi J. Heijnen, Philip Jones, Qi Wu, Michael J. Soth, Sunil Goodwani
Publikováno v:
Pain
Supplemental Digital Content is Available in the Text. Dual leucine zipper kinase inhibition is a promising therapeutic strategy against chemotherapy-induced neurotoxicities including chemotherapy-induced peripheral neuropathy and chemotherapy-induce
Autor:
Virginie Buggia-Prevot, William J. Ray
Publikováno v:
Annual Review of Medicine. 72:15-28
Genetic studies of autosomal dominant Alzheimer's disease (AD) revealed that β-amyloid is central to disease pathogenesis. However, amyloid-targeted therapies have generally failed to slow progression in patients with symptomatic disease. This resul
Publikováno v:
Alzheimer's & Dementia. 17