Zobrazeno 1 - 10
of 45
pro vyhledávání: '"William J. Racz"'
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 336:551-559
Amiodarone (AM) is a potent antidysrhythmic agent that can cause potentially life-threatening pulmonary fibrosis, and N-desethylamiodarone (DEA), an AM metabolite, may contribute to AM toxicity. Apoptotic cell death in nontransformed human peripheral
Autor:
Jeannette L. Comeau, Thomas E. Massey, Takashi Takahashi, Bruce C. Hill, Adrian C. Nicolescu, Leanne L. Bedard, James F. Brien, William J. Racz
Publikováno v:
Toxicology and Applied Pharmacology. 220:60-71
Amiodarone (AM), an antidysrrhythmic drug, can produce serious adverse effects, including potentially fatal AM-induced pulmonary toxicity (AIPT). AM-induced cytotoxicity and pulmonary fibrosis are well recognized, but poorly understood mechanisticall
Publikováno v:
Toxicology. 190:3-14
This paper will provide an overview of the on-line resources available in toxicology in Canada. It will describe a brief history of The Society of Toxicology of Canada, with reference to other societies and also provide information on education, rese
Publikováno v:
Toxicological Sciences. 75:169-180
Pulmonary toxicity, including fibrosis, is a serious adverse effect associated with the antidysrhythmic drug amiodarone (AM). We tested the potential usefulness of pirfenidone against AM-induced pulmonary toxicity in the hamster model. Intratracheal
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 304:121-129
Hepatotoxicity induced by 1,1-dichloroethylene (DCE) is mediated by cytochrome P450-dependent metabolism to reactive intermediates, including the epoxide. We have tested the hypothesis that mitochondria are a primary target of toxicity by investigati
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 281:L1180-L1188
Amiodarone (AM) is an antidysrhythmic agent with a propensity to cause pulmonary toxicity, including potentially fatal fibrosis. In the present study, the potential roles of c-Jun and transforming growth factor (TGF)-β1 in AM-induced inflammation an
Publikováno v:
Toxicology Letters. 116:171-181
Bromobenzene (BB) and furosemide (FS) are two hepatotoxicants whose bioactivation to reactive intermediates is crucial to the development of liver injury. However, the events which lead to hepatocellular toxicity following metabolite formation and co
Publikováno v:
The Journal of Urology. :1315-1321
Purpose:: Erectile function is testosterone dependent. For example, interference with either the levels or receptor binding of this steroid hormone may induce erectile dysfunction. Several environmental contaminants can interfere with the actions of
Autor:
William J. Racz, Bettina E. Kalisch
Publikováno v:
Toxicology Letters. 89:43-49
The present study investigated the effects of in vitro methylmercury (MeHg) exposure on endogenous dopamine (DA) efflux from mouse striatal slices. MeHg produced a concentration-dependent increase in the spontaneous efflux of DA which was independent
Publikováno v:
Canadian Journal of Physiology and Pharmacology. 74:257-264
On ignore comment les formes actives intermediaires resultant de la bioactivation du bromobenzene et du furosemide induisent l'hepatotoxicite. Des perturbations dans l'homeostasie du calcium intracellulaire, suite a un appauvrissement de la teneur ce