Zobrazeno 1 - 10
of 52
pro vyhledávání: '"William J. Placzek"'
Autor:
Alexus Acton, William J. Placzek
Publikováno v:
Cancers, Vol 15, Iss 18, p 4481 (2023)
Triple-negative breast cancer (TNBC) is an aggressive cancer that lacks specific molecular targets that are often used for therapy. The refractory rate of TNBC to broad-spectrum chemotherapy remains high; however, the combination of newly developed t
Externí odkaz:
https://doaj.org/article/8d99e4559cb74467ae8be35bc04650eb
Autor:
Christine Carico, William J. Placzek
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 13, p 11218 (2023)
Polypyrimidine tract binding protein 1 (PTBP1) is one of the most well-described RNA binding proteins, known initially for its role as a splicing repressor before later studies revealed its numerous roles in RNA maturation, stability, and translation
Externí odkaz:
https://doaj.org/article/0572d3d06e544c6c9ee498232da88cfc
Autor:
Hayley Widden, William J. Placzek
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
In this review Widden and Placzek synthesize studies characterizing the influence that myeloid cell leukemia-1 (MCL1) has on cell proliferation, DNA damage response, autophagy, calcium handling, and mitochondrial quality control to highlight the broa
Externí odkaz:
https://doaj.org/article/3e4c89c0ce7e405aa2ea6b1f132107cc
Autor:
Robert H. Whitaker, William J. Placzek
Publikováno v:
Cells, Vol 8, Iss 4, p 346 (2019)
Chemotherapeutic targeting of microtubules has been the standard of care in treating a variety of malignancies for decades. During mitosis, increased microtubule dynamics are necessary for mitotic spindle formation and successful chromosomal segregat
Externí odkaz:
https://doaj.org/article/12cc624f39ac4d918df7e3e2a8c3c476
Autor:
Jia Cui, William J. Placzek
Publikováno v:
International Journal of Molecular Sciences, Vol 19, Iss 1, p 308 (2018)
Anti-apoptotic B cell lymphoma 2 (BCL2) family members (BCL2, MCL1, BCLxL, BCLW, and BFL1) are key players in the regulation of intrinsic apoptosis. Dysregulation of these proteins not only impairs normal development, but also contributes to tumor pr
Externí odkaz:
https://doaj.org/article/702be8e6de06404f8baf088bc3a9a014
Publikováno v:
Journal of Biological Chemistry. :104778
Autor:
Anirban Kundu, Garrett J. Brinkley, Hyeyoung Nam, Suman Karki, Richard Kirkman, Hayley Widden, Michelle Johnson, Juan Liu, Yasaman Heidarian, Nader Mahmoudzadeh, Devin Absher, Han-Fei Ding, David Crosman, William J. Placzek, Jason Locasale, Dinesh Rakheja, Victor Darley-Usmar, Jason Tennessen, Sunil Sudarshan
Publikováno v:
Cancer Research. 83:3705-3705
The oncometabolite, L-2-hydroxyglutarate (L-2HG) is elevated in the most common form of renal cell carcinoma-RCC (clear cell histology) and promotes tumor progression. L-2HG is structurally similar to α-ketoglutarate (α-KG). Therefore, L-2HG can co
Autor:
Anna McGriff, William J. Placzek
Publikováno v:
PLOS ONE. 18:e0277726
B-cell lymphoma 2 (Bcl-2) proteins are central, conserved regulators of apoptosis. Bcl-2 family function is regulated by binding interactions between the Bcl-2 homology 3 (BH3) motif in pro-apoptotic family members and the BH3 binding groove found in
Autor:
Zeel Patel, Hayley Widden, Hasan Alrefai, Anita B. Hjelmeland, Patricia H. Hicks, Jason M. Warram, Rune T. Pedersen, G. Yancey Gillespie, Christopher D. Willey, William J. Placzek, Nicholas Eustace, Joshua C. Anderson
Publikováno v:
Oncogene
Glioblastoma (GBM) is an aggressive malignancy with limited effectiveness of standard of care therapies including surgery, radiation, and temozolomide chemotherapy necessitating novel therapeutics. Unfortunately, GBMs also harbor several signaling al
Autor:
William J. Placzek, Hayley Widden
Publikováno v:
Communications Biology
Communications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
Communications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
MCL1 (myeloid cell leukemia-1) is a widely recognized pro-survival member of the Bcl-2 (B-cell lymphoma protein 2) family and a promising target for cancer therapy. While the role MCL1 plays in apoptosis is well defined, its participation in emerging