Zobrazeno 1 - 10
of 34
pro vyhledávání: '"William J. Netzer"'
Autor:
William J. Netzer, Anjana Sinha, Mondana Ghias, Emily Chang, Katherina Gindinova, Emily Mui, Ji-Seon Seo, Subhash C. Sinha
Publikováno v:
Frontiers in Chemistry, Vol 12 (2024)
We previously showed that the anticancer drug imatinib mesylate (IMT, trade name: Gleevec) and a chemically distinct compound, DV2-103 (a kinase-inactive derivative of the potent Abl and Src kinase inhibitor, PD173955) lower Aβ levels at low micromo
Externí odkaz:
https://doaj.org/article/8e5f35bf5ec14ed0b3b22c64a5fe5708
Publikováno v:
ACS Med Chem Lett
[Image: see text] Compound 3a, DV2-103, is a kinase inactive analogue of a potent Abl1/Src kinase inhibitor, PD173955, 2. Both compounds, 2 and 3a, are known to reduce production of beta amyloid (Aβ) peptide in cells and animal models. We have now p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a52c57d5707c7c22a2081bbcf37ed6b
https://doi.org/10.1021/acsmedchemlett.9b00213
https://doi.org/10.1021/acsmedchemlett.9b00213
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e45033 (2012)
BACKGROUND: Several lines of investigation support the notion that endocytosis is crucial for Alzheimer's disease (AD) pathogenesis. Substantial evidence have already been reported regarding the mechanisms underlying amyloid precursor protein (APP) t
Externí odkaz:
https://doaj.org/article/82dcfd4ac41542b8b5b17a57d7f3fe96
Autor:
William J Netzer, Craig Powell, Yi Nong, Jacqueline Blundell, Lili Wong, Karen Duff, Marc Flajolet, Paul Greengard
Publikováno v:
PLoS ONE, Vol 5, Iss 6, p e10943 (2010)
beta-amyloid levels are elevated in Down syndrome (DS) patients throughout life and are believed to cause Alzheimer's disease (AD) in adult members of this population. However, it is not known if beta-amyloid contributes to intellectual disability in
Externí odkaz:
https://doaj.org/article/4220ca82a5624c5c9a26db686f44859e
Publikováno v:
European Journal of Pharmaceutical Sciences. 102:46-54
The delivery of drugs to the brain is a constant challenge due to limitations imposed by the blood-brain barrier (BBB). Various methods of bypassing the BBB are under investigation. One approach is intranasal administration, where the olfactory regio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bdffcbac48485f500ddcb4c450859b2
https://doi.org/10.1016/j.ejps.2017.02.032
https://doi.org/10.1016/j.ejps.2017.02.032
Autor:
Weilin Sun, Katherina Gindinova, Subhash C. Sinha, Emily Chang, William J. Netzer, Anjana Sinha
Publikováno v:
Journal of medicinal chemistry. 62(6)
Imatinib mesylate, 1a, inhibits production of β-amyloid (Aβ) peptides both in cells and in animal models. It reduces both the β-secretase and γ-secretase cleavages of the amyloid precursor protein (APP) and mediates a synergistic effect, when com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcccf18d51b1ab8c9e7719072b6ea3a6
https://pubmed.ncbi.nlm.nih.gov/30873837
https://pubmed.ncbi.nlm.nih.gov/30873837
Autor:
Paul Greengard, William J. Netzer, Victor Bustos, Subhash C. Sinha, Marc Flajolet, Karima Bettayeb
Neurotoxic amyloid-β peptides (Aβ) are major drivers of Alzheimer's disease (AD) and are formed by sequential cleavage of the amyloid precursor protein (APP) by β-secretase (BACE) and γ-secretase. Our previous study showed that the anticancer dru
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd5b2d697720ad9447bc7c267ef6c16e
https://europepmc.org/articles/PMC5307477/
https://europepmc.org/articles/PMC5307477/
Autor:
Minghao Zhong, Ina Caesar, Lijuan Liu, Victor Bustos, William J. Netzer, Dongming Cai, Li Zhu, Nikolaos K. Robakis, Hannah Rhee, Louise Lucast, Michelle E. Ehrlich, Laura A. Volpicelli-Daley, Elysse M. Knight, Jiaying Zhao, Sam Gandy
Publikováno v:
Journal of Biological Chemistry. 288:32050-32063
Recent studies link synaptojanin 1 (synj1), the main phosphoinositol (4,5)-biphosphate phosphatase (PI(4,5)P2-degrading enzyme) in the brain and synapses, to Alzheimer disease. Here we report a novel mechanism by which synj1 reversely regulates cellu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed5c529cbe055083763351543093e3c8
https://doi.org/10.1074/jbc.m113.504365
https://doi.org/10.1074/jbc.m113.504365
Autor:
Suvekshya Aryal, William J. Netzer, Jerry C. Chang, Karima Bettayeb, Dante Varotsis, Wenjie Luo, Lisa Randolph, Paul Greengard, Marc Flajolet
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 113(19)
The components involved in cellular trafficking and protein recycling machinery that have been associated with increased Alzheimer's disease (AD) risk belong to the late secretory compartments for the most part. Here, we hypothesize that these late u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d92ba22f353bab3c6527f543be330e2
https://pubmed.ncbi.nlm.nih.gov/27114525
https://pubmed.ncbi.nlm.nih.gov/27114525
Autor:
Roberto Malinow, Paul J. Lombroso, Jeannie Chin, Sylvain Lesné, Deepa V. Venkitaramani, William J. Netzer, Gunnar K. Gouras
Publikováno v:
The Journal of Neuroscience. 27:11832-11837
The sequencing of β amyloid protein (Aβ) in 1984 led to the formulation of the “amyloid hypothesis” of Alzheimer's disease (AD) ([Glenner and Wong, 1984][1]). The hypothesis proposed that accumulation of Aβ is responsible for AD-related pathol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c213e6fbf62a1b7f21deb26303c96b2
https://doi.org/10.1523/jneurosci.3478-07.2007
https://doi.org/10.1523/jneurosci.3478-07.2007