Zobrazeno 1 - 10
of 562
pro vyhledávání: '"William J. Muller"'
Autor:
Ipshita Nandi, Linjia Ji, Harvey W. Smith, Daina Avizonis, Vasilios Papavasiliou, Cynthia Lavoie, Alain Pacis, Sherif Attalla, Virginie Sanguin-Gendreau, William J. Muller
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract Metabolic reprogramming, a hallmark of tumorigenesis, involves alterations in glucose and fatty acid metabolism. Here, we investigate the role of Carnitine palmitoyl transferase 1a (Cpt1a), a key enzyme in long-chain fatty acid (LCFA) oxidat
Externí odkaz:
https://doaj.org/article/052dee2b00604ae3ada71ece23a9fb36
Autor:
Nandini Raghuram, E. Idil Temel, Toshihiro Kawamata, Katelyn J. Kozma, Amanda J. Loch, Wei Wang, Jessica R. Adams, William J. Muller, Sean E. Egan
Publikováno v:
Breast Cancer Research, Vol 26, Iss 1, Pp 1-12 (2024)
Abstract Copy number gains in genes coding for Rho activating exchange factors as well as losses affecting genes coding for RhoGAP proteins are common in breast cancer (BC), suggesting that elevated Rho signaling may play an important role. Extra cop
Externí odkaz:
https://doaj.org/article/9bb3dfba366749538f9812dc3140b0b5
Autor:
Julia E. Moss, William J. Muller
Publikováno v:
Frontiers in Pediatrics, Vol 11 (2024)
IntroductionBK virus-associated hemorrhagic cystitis (BK-HC) is a debilitating and poorly understood complication of hematopoietic stem cell transplantation (SCT). Hematuria, dysuria, and other symptoms associated with BK-HC are common in the immedia
Externí odkaz:
https://doaj.org/article/d4f50a153c724f73b1dd1febf585283f
Autor:
Arghavan Alisoltani, Lacy M. Simons, Maria Francesca Reyes Agnes, Taylor A. Heald-Sargent, William J. Muller, Larry K. Kociolek, Judd F. Hultquist, Ramon Lorenzo-Redondo, Egon A. Ozer
Publikováno v:
Virology Journal, Vol 20, Iss 1, Pp 1-12 (2023)
Abstract Background Persistent SARS-CoV-2 infection in immunocompromised hosts is thought to contribute to viral evolution by facilitating long-term natural selection and viral recombination in cases of viral co-infection or superinfection. However,
Externí odkaz:
https://doaj.org/article/4f9b28299fc94ce1b8fc949466b31f88
Autor:
Himanshu P. Upadhyaya, Jenny Y. Chien, Amanda J. Long, Martin S. Bohm, Nicole L. Kallewaard, Lisa F. Macpherson, Dipak R. Patel, Matthew M. Hufford, Constance J. Krull, Jocelyn Y. Ang, Peter Chen, William J. Muller, Jeffrey A. Potts, Timothy Quinn, Mark Williams, BLAZE-1 Investigators
Publikováno v:
Infectious Diseases and Therapy, Vol 12, Iss 7, Pp 1861-1873 (2023)
Abstract Introduction Bamlanivimab and etesevimab (BAM + ETE) are monoclonal antibodies (mAbs) effective in reducing COVID-19-related hospitalizations and all-cause mortality in adult participants at increased risk for severe disease. We present phar
Externí odkaz:
https://doaj.org/article/4a8e4f959324473bb550800f3098224f
Autor:
Xianghong Kuang, Andrew Salinger, Fernando Benavides, William J. Muller, Sharon Y. R. Dent, Evangelia Koutelou
Publikováno v:
PLoS ONE, Vol 19, Iss 1 (2024)
Externí odkaz:
https://doaj.org/article/0a9b6f6df1354369bd12791254dcb361
Autor:
Marie-Anne Goyette, Stéphanie Duhamel, Léo Aubert, Ariane Pelletier, Paul Savage, Marie-Pier Thibault, Radia Marie Johnson, Peter Carmeliet, Mark Basik, Louis Gaboury, William J. Muller, Morag Park, Philippe P. Roux, Jean-Philippe Gratton, Jean-François Côté
Publikováno v:
Cell Reports, Vol 42, Iss 12, Pp 113604- (2023)
Externí odkaz:
https://doaj.org/article/d9a9b40ac45647d0834726998922a5ff
Autor:
Yi He, Marie-Anne Goyette, Jennifer Chapelle, Nadia Boufaied, Jalal Al Rahbani, Maribel Schonewolff, Eric I. Danek, William J. Muller, David P. Labbé, Jean-François Côté, Nathalie Lamarche-Vane
Publikováno v:
Cell Reports, Vol 42, Iss 8, Pp 112936- (2023)
Summary: Epithelial-to-mesenchymal transition (EMT) plays a crucial role in metastasis, which is the leading cause of death in breast cancer patients. Here, we show that Cdc42 GTPase-activating protein (CdGAP) promotes tumor formation and metastasis
Externí odkaz:
https://doaj.org/article/99945987e095410c96e9de7bda1ae234
Autor:
Catherine R. Dufour, Hui Xia, Wafa B’chir, Marie-Claude Perry, Uros Kuzmanov, Anastasiia Gainullina, Kurt Dejgaard, Charlotte Scholtes, Carlo Ouellet, Dongmei Zuo, Virginie Sanguin-Gendreau, Christina Guluzian, Harvey W. Smith, William J. Muller, Etienne Audet-Walsh, Alexey A. Sergushichev, Andrew Emili, Vincent Giguère
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-17 (2022)
Murine hearts deficient in ErbB2 and/or ERRα are used to profile the adverse cardiac remodeling associated with potential targeted breast cancer treatments by phosphoproteomic, transcriptomic and metabolomic profiling.
Externí odkaz:
https://doaj.org/article/ddcceb39187b47f3a0dc86d4bc298e2e
Autor:
Jacqueline G. Gerhart, Fernando O. Carreño, Jennifer L. Ford, Andrea N. Edginton, Eliana M. Perrin, Kevin M. Watt, William J. Muller, Andrew M. Atz, Amira Al‐Uzri, Paula Delmore, Daniel Gonzalez, Best Pharmaceuticals for Children Act–Pediatric Trials Network Steering Committee
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 11, Iss 6, Pp 778-791 (2022)
Abstract Obesity is an increasingly alarming public health threat, with nearly 20% of children classified as obese in the United States today. Children with obesity are commonly prescribed the opioids fentanyl and methadone, and accurate dosing is cr
Externí odkaz:
https://doaj.org/article/dd4ab2e51fa44b86a239b72f4ea91718