Zobrazeno 1 - 10
of 10
pro vyhledávání: '"William J. Kissner"'
Autor:
Kaitlyn R. Rouillard, Christopher P. Esther, William J. Kissner, Lucas M. Plott, Dean W. Bowman, Matthew R. Markovetz, David B. Hill
Publikováno v:
PLoS ONE, Vol 19, Iss 2 (2024)
Externí odkaz:
https://doaj.org/article/5c65134c82964ce98370313c40b1e9ce
Autor:
Kaitlyn R. Rouillard, Matthew R. Markovetz, William J. Kissner, William L. Boone, Lucas M. Plott, David B. Hill
Publikováno v:
Biofilm, Vol 5, Iss , Pp 100104- (2023)
The viscoelastic properties of biofilms are correlated with their susceptibility to mechanical and chemical stress, and the airway environment in muco-obstructive pulmonary diseases (MOPD) facilitates robust biofilm formation. Hyperconcentrated, visc
Externí odkaz:
https://doaj.org/article/c753f2302b8144688c2a073fe72f466c
Autor:
Matthew R. Markovetz, Jacob E. Hibbard, Lucas M. Plott, Lawrence G. Bacudio, William J. Kissner, Andrew Ghio, Priya A. Kumar, Harendra Arora, David B. Hill
Publikováno v:
Frontiers in Physiology, Vol 14 (2023)
Across the globe, millions of people are affected by muco-obstructive pulmonary diseases like cystic fibrosis, asthma, and chronic obstructive pulmonary disease. In MOPDs, the airway mucus becomes hyperconcentrated, increasing viscoelasticity and imp
Externí odkaz:
https://doaj.org/article/1f0605540aca4c1b8f60f009b529f4bb
Publikováno v:
mSphere, Vol 7, Iss 4 (2022)
ABSTRACT The pathological properties of airway mucus in cystic fibrosis (CF) are dictated by mucus concentration and composition, with mucins and DNA being responsible for mucus viscoelastic properties. As CF pulmonary disease progresses, the concent
Externí odkaz:
https://doaj.org/article/c90a0a37058d42b885c7d2990e83176b
Autor:
Laura A. Hancock, Corinne E. Hennessy, George M. Solomon, Evgenia Dobrinskikh, Alani Estrella, Naoko Hara, David B. Hill, William J. Kissner, Matthew R. Markovetz, Diane E. Grove Villalon, Matthew E. Voss, Guillermo J. Tearney, Kate S. Carroll, Yunlong Shi, Marvin I. Schwarz, William R. Thelin, Steven M. Rowe, Ivana V. Yang, Christopher M. Evans, David A. Schwartz
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
The promoter variant rs35705950 confers a gain of function to the MUC5B gene and is the dominant risk factor for idiopathic pulmonary fibrosis. Here the authors show that mice overexpressing Muc5b in distal airspaces show impaired mucociliary clearan
Externí odkaz:
https://doaj.org/article/179e7c61d4b74fa68c0ec80470732ff6
Autor:
Matthew R. Markovetz, Ian C. Garbarine, Cameron B. Morrison, William J. Kissner, Ian Seim, M. Gregory Forest, Micah J. Papanikolas, Ronit Freeman, Agathe Ceppe, Andrew Ghio, Neil E. Alexis, Stephen M. Stick, Camille Ehre, Richard C. Boucher, Charles R. Esther, Marianne S. Muhlebach, David B. Hill
Publikováno v:
Journal of Cystic Fibrosis. 21:959-966
Mucus hyperconcentration in cystic fibrosis (CF) lung disease is marked by increases in both mucin and DNA concentration. Additionally, it has been shown that half of the mucins present in bronchial alveolar lavage fluid (BALF) from preschool-aged CF
Autor:
Jennifer L. Schiller, Olivia Bussey, Samuel K. Lai, Mary M. Fogle, William J. Kissner, David B. Hill
Publikováno v:
Acta Biomater
N-glycans on IgG and IgM antibodies (Ab) facilitate Ab-mediated crosslinking of viruses and nanoparticles to the major structural elements of mucus and basement membranes. Nevertheless, the chemical moieties in these biological hydrogel matrices to w
Autor:
Kate S. Carroll, George M. Solomon, Yunlong Shi, Steven M. Rowe, Alani Estrella, Christopher M. Evans, Evgenia Dobrinskikh, Marvin I. Schwarz, Matthew R. Markovetz, Naoko Hara, Ivana V. Yang, Diane E. Grove Villalon, David B. Hill, Corinne E. Hennessy, William J. Kissner, Laura A. Hancock, Guillermo J. Tearney, Matthew E. Voss, David A. Schwartz, William R. Thelin
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
Nature Communications
Nature Communications
The gain-of-function MUC5B promoter variant rs35705950 is the dominant risk factor for developing idiopathic pulmonary fibrosis (IPF). Here we show in humans that MUC5B, a mucin thought to be restricted to conducting airways, is co-expressed with sur
Autor:
Camille Ehre, Tadahiro Kumagai, David B. Nix, Giorgia Radicioni, Harendra Arora, Neil E. Alexis, William J. Kissner, Michael Tiemeyer, Kathryn A. Ramsey, Ian C. Garbarine, Cameron B. Morrison, Richard C. Boucher, Priya A. Kumar, Mehmet Kesimer, Duncan C. Krause, David B. Hill, Andrew J. Ghio, Thomas M. Krunkosky, Durai B. Subramani, Matthew R. Markovetz
Publikováno v:
Am J Physiol Lung Cell Mol Physiol
Muco-obstructive lung diseases (MOLDs), like cystic fibrosis and chronic obstructive pulmonary disease, affect a spectrum of subjects globally. In MOLDs, the airway mucus becomes hyperconcentrated, increasing osmotic and viscoelastic moduli and impai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7381fe9b8d723d21762e6b01f3d3176a
https://europepmc.org/articles/PMC6842913/
https://europepmc.org/articles/PMC6842913/
Autor:
Robert Tarran, Matthew R. Markovetz, William J. Kissner, Robert F. Long, Matthew Christy, M. Gregory Forest, Nicholas C. Fontana, Brian Button, Richard C. Boucher, Ian C. Garbarine, David B. Hill, Eyad Atieh, Mehdi Habibpour
Publikováno v:
European Respiratory Journal. 52:1801297
Cystic fibrosis (CF) is a recessive genetic disease that is characterised by airway mucus plugging and reduced mucus clearance. There are currently alternative hypotheses that attempt to describe the abnormally viscous and elastic mucus that is a hal