Výsledky vyhledávání - "William J. Holmes"

Understanding the yeast host cell response to recombinant membrane protein production

Autor: Matthew T. Conner, Michelle Clare, Nicklas Bonander, William J. Holmes, Stephanie P. Cartwright, Charlotte E. Bland, Nagamani Bora, Roslyn M. Bill, Stephane R. Gross, Sarah J Routledge, Zharain Bawa, Mohammed Jamshad, Marvin V. Dilworth, Richard A. J. Darby

Publikováno v: Biochemical Society transactions. 39(3)

Membrane proteins are drug targets for a wide range of diseases. Having access to appropriate samples for further research underpins the pharmaceutical industry's strategy for developing new drugs. This is typically achieved by synthesizing a protein

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acddae53cd725e6c59e72c02b11fb998
https://pubmed.ncbi.nlm.nih.gov/21599640

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Developing a scalable model of recombinant protein yield from Pichia pastoris: the influence of culture conditions, biomass and induction regime

Autor: Roslyn M. Bill, Richard A. J. Darby, William J. Holmes, Rodney Smith, Martin D.B. Wilks

Publikováno v: Microbial Cell Factories
Microbial Cell Factories, Vol 8, Iss 1, p 35 (2009)

Background The optimisation and scale-up of process conditions leading to high yields of recombinant proteins is an enduring bottleneck in the post-genomic sciences. Typical experiments rely on varying selected parameters through repeated rounds of t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54fd487f0d1fa7d2966414a363a1a1b7
https://pubmed.ncbi.nlm.nih.gov/19570229

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[Untitled]

Autor: Rodney Smith, Roslyn M. Bill, William J. Holmes

Publikováno v: Microbial Cell Factories. 5:P30

Background Optimisation of culture conditions for the expression and production of important therapeutic biologics such as recombinant proteins, antibody-fragments and fusion proteins is a key element in the rapid and cost effective manufacture of th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::604aaa61dad979fdf7bc7f0f6291caaf
https://doi.org/10.1186/1475-2859-5-s1-p30

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