Zobrazeno 1 - 10
of 20
pro vyhledávání: '"William J. Grossman"'
Autor:
David A. Margolis, Christine M. Seroogy, Benedetta Bonacci, James T. Casper, Ken B. DeSantes, Gary Hoffman, James W. Verbsky, Trivikram Dasu, William J. Grossman, John M. Routes, Charles D. Brokopp, Sreelatha T. Reddy, Mary Hintermeyer, Miranda Gries, Mei W. Baker
Publikováno v:
Journal of Clinical Immunology. 32:82-88
Severe combined immunodeficiency is a life-threatening primary immune deficiency characterized by low numbers of naïve T cells. Early diagnosis and treatment of this disease decreases mortality. In 2008, Wisconsin began newborn screening of infants
Autor:
John M. Routes, Daniel F.I. Kurtycz, Charles D. Brokopp, Ronald H. Laessig, Gary Hoffman, Murray L. Katcher, Michael F. Cogley, Mei W. Baker, Thomas J. Litsheim, William J. Grossman
Publikováno v:
Journal of Allergy and Clinical Immunology. 124:522-527
Background Severe combined immunodeficiency (SCID) is characterized by the absence of functional T cells and B cells. Without early diagnosis and treatment, infants with SCID die from severe infections within the first year of life. Objective To dete
Autor:
Dipica Haribhai, Manoj K. Mishra, Parthav Jailwala, Renren Wen, Demin Wang, Srikanta Jana, Soumitra Ghosh, William J. Grossman, Jill Waukau, Calvin B. Williams, Sanja Glisic
Publikováno v:
European Journal of Immunology. 39:2571-2583
The transcription factor Foxp3 is essential for the development of functional, natural Treg (nTreg), which plays a prominent role in self-tolerance. Suppressive Foxp3(+) Treg cells can be generated from naïve T cells ex vivo, following TCR and TGF-b
Autor:
William J. Grossman, James W. Verbsky
Publikováno v:
Pediatric Clinics of North America. 53:649-684
Knowledge of the genetic mutations of primary immune deficiency syndromes has grown significantly over the last 30 years. In this article the authors present an overview of the clinical aspects, laboratory evaluation, and genetic defects of primary i
Autor:
Charles Grose, Frederick D. Goldman, Erick Gerday, William J. Grossman, Dennis W. Schauer, Mohammed Radhi
Publikováno v:
Blood. 106:1203-1206
Hemophagocytic lymphohistiocytosis (HLH) is a rare disorder of immune dysregulation, characterized by end-organ damage from lymphocytic infiltration and macrophage activation. All known mutations associated with the HLH occur in genes critical in the
Autor:
William J. Grossman, Lee Ratner
Publikováno v:
Blood. 90:783-794
The human T-cell leukemia virus type I (HTLV-I) regulatory protein, Tax, has been speculated to play a major role in HTLV-I leukemogenesis. Indeed, several studies have suggested that upregulation of various cellular oncogenes and cytokines by Tax ma
Autor:
Charles D. Brokopp, William J. Grossman, Ronald H. Laessig, Murray L. Katcher, Mei W. Baker, James W. Verbsky, Daniel F.I. Kurtycz, John M. Routes
Severe combined immunodeficiency (SCID) is the result of genetic defects that impair normal T-cell development. SCID babies typically appear normal at birth, but acquire multiple life-threatening infections within a few months. Early diagnosis and tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c265f1e71dc1254676d3f7e4d216dfb2
https://europepmc.org/articles/PMC2846807/
https://europepmc.org/articles/PMC2846807/
Autor:
William J. Grossman, James W. Verbsky
Publikováno v:
Pediatric Research
Granzymes (Grs), serine proteases present in granules of effector lymphocytes, are involved in several host immune responses, including the activation of cell death and inflammatory pathways. The main goal of this study was to determine whether the l
Autor:
James W. Verbsky, William J. Grossman
Publikováno v:
Annals of medicine. 38(1)
Hemophagocytic lymphohistiocytosis (HLH) is a rare life-threatening disease in which the immune system becomes overactive due to its inability to effectively respond to infections and/or shut down the immune response to such infections. The discovery
Autor:
William J. Grossman, Christine M. Seroogy, Stephanie Markovina, Ashley T. Doan, William T. Simonson, Mary A. Lokuta, Anna Huttenlocher
Publikováno v:
Annals of Allergy, Asthma & Immunology. 102:170-171