Zobrazeno 1 - 10
of 98
pro vyhledávání: '"William J. Gibson"'
Publikováno v:
Respiratory Medicine Case Reports, Vol 52, Iss , Pp 102118- (2024)
Background: The rearranged during transfection (RET) gene is on chromosome 10 (10q11.2) and normally encodes a receptor tyrosine kinase that plays a role in the development of the kidney, nervous, and respiratory systems.Aberrant RET gene activation
Externí odkaz:
https://doaj.org/article/d2a23414e1b54b2fb555100bc8a88076
Autor:
Caitlin A. Nichols, William J. Gibson, Meredith S. Brown, Jack A. Kosmicki, John P. Busanovich, Hope Wei, Laura M. Urbanski, Naomi Curimjee, Ashton C. Berger, Galen F. Gao, Andrew D. Cherniack, Sirano Dhe-Paganon, Brenton R. Paolella, Rameen Beroukhim
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
In tumors, hundreds of genes can undergo loss of heterozygosity (LOH). Here, the authors investigate the potential for this LOH as a class of non-driver cancer vulnerabilities.
Externí odkaz:
https://doaj.org/article/86a1e531ffce47339d04b2ee5dc0b8e0
Autor:
William J. Gibson, C. Michael Gibson, Megan K. Yee, Serge Korjian, Yazan Daaboul, Alexei N. Plotnikov, Paul Burton, Eugene Braunwald
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 8, Iss 5 (2019)
Background A residual risk of ischemic events following an acute coronary syndrome (ACS) remains despite antiplatelet therapy. The addition of an antithrombin as part of a “dual pathway” approach may further improve outcomes as thrombin generatio
Externí odkaz:
https://doaj.org/article/43859572e00b45b9b5db9cd7e5945c74
Autor:
Helga B. Salvesen, Rameen Beroukhim, Camilla Krakstad, Christian F. Singer, Gordon B. Mills, Karl-Henning Kalland, Andrew D. Cherniack, Jone Trovik, Mari K. Halle, William J. Gibson, Even Birkeland, Anna Berg, Elisabeth Wik, Kanthida Kusonmano, Erling A. Hoivik, Siv Mjøs, Henrica M.J. Werner, Frederik Holst
Purpose:Amplification of PIK3CA, encoding the PI3K catalytic subunit alpha, is common in uterine corpus endometrial carcinoma (UCEC) and linked to an aggressive phenotype. However, it is unclear whether PIK3CA amplification acts via PI3K activation.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53e5df26a03b01ecae2ecb126db07778
https://doi.org/10.1158/1078-0432.c.6529077.v1
https://doi.org/10.1158/1078-0432.c.6529077.v1
Autor:
Yoon-Jae Cho, Rameen Beroukhim, James E. Bradner, Mark W. Kieran, Fredrik J. Swartling, William A. Weiss, Robert Wechsler-Reya, Kun-Wei Liu, Jun Qi, Samuel H. Cheshier, Siddhartha S. Mitra, Brenton R. Paolella, William J. Gibson, Nujsaubnusi Vue, Furong Yu, Sabran Masoud, Rhamy Zeid, Steven E. Schumacher, Sara Bolin, Yujie Tang, Sharareh Gholamin, Simone Schubert, Brian Nguyen, Guillaume Bergthold, Pratiti Bandopadhayay
PDF file - 386K, A, Cell viability relative to day 0 is shown following the indicated treatments in the indicated cell lines. Error bars represent the mean plus-minus SD of three replicates per condition. B, qPCR assessment of MYC mRNA expression in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c28be7bf2edac35abba7faa9dddb9fe
https://doi.org/10.1158/1078-0432.22450230
https://doi.org/10.1158/1078-0432.22450230
Autor:
Yoon-Jae Cho, Rameen Beroukhim, James E. Bradner, Mark W. Kieran, Fredrik J. Swartling, William A. Weiss, Robert Wechsler-Reya, Kun-Wei Liu, Jun Qi, Samuel H. Cheshier, Siddhartha S. Mitra, Brenton R. Paolella, William J. Gibson, Nujsaubnusi Vue, Furong Yu, Sabran Masoud, Rhamy Zeid, Steven E. Schumacher, Sara Bolin, Yujie Tang, Sharareh Gholamin, Simone Schubert, Brian Nguyen, Guillaume Bergthold, Pratiti Bandopadhayay
PDF file - 567K, A, Gene expression sub-group profiling of MB002 and MB004 patient-derived medulloblastoma cell lines. B, Western blot (left) and densitometry of western blot (right) depicting MYC expression relative to β actin loading control in pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69daa5f6bfce62d893f5fe33f240c6a5
https://doi.org/10.1158/1078-0432.22450233.v1
https://doi.org/10.1158/1078-0432.22450233.v1
Autor:
Yoon-Jae Cho, Rameen Beroukhim, James E. Bradner, Mark W. Kieran, Fredrik J. Swartling, William A. Weiss, Robert Wechsler-Reya, Kun-Wei Liu, Jun Qi, Samuel H. Cheshier, Siddhartha S. Mitra, Brenton R. Paolella, William J. Gibson, Nujsaubnusi Vue, Furong Yu, Sabran Masoud, Rhamy Zeid, Steven E. Schumacher, Sara Bolin, Yujie Tang, Sharareh Gholamin, Simone Schubert, Brian Nguyen, Guillaume Bergthold, Pratiti Bandopadhayay
PDF file - 72K, Nanostring CNV of MB002 and MB004.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b7cb1104e35b9e0c96d3a8414793743
https://doi.org/10.1158/1078-0432.22450224
https://doi.org/10.1158/1078-0432.22450224
Autor:
Helga B. Salvesen, Rameen Beroukhim, Camilla Krakstad, Christian F. Singer, Gordon B. Mills, Karl-Henning Kalland, Andrew D. Cherniack, Jone Trovik, Mari K. Halle, William J. Gibson, Even Birkeland, Anna Berg, Elisabeth Wik, Kanthida Kusonmano, Erling A. Hoivik, Siv Mjøs, Henrica M.J. Werner, Frederik Holst
Correlation between copy number status determined by FISH and microarrays.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3dc8d2d20376ec69659f262e4b7af853
https://doi.org/10.1158/1078-0432.22475445
https://doi.org/10.1158/1078-0432.22475445
Autor:
Yoon-Jae Cho, Rameen Beroukhim, James E. Bradner, Mark W. Kieran, Fredrik J. Swartling, William A. Weiss, Robert Wechsler-Reya, Kun-Wei Liu, Jun Qi, Samuel H. Cheshier, Siddhartha S. Mitra, Brenton R. Paolella, William J. Gibson, Nujsaubnusi Vue, Furong Yu, Sabran Masoud, Rhamy Zeid, Steven E. Schumacher, Sara Bolin, Yujie Tang, Sharareh Gholamin, Simone Schubert, Brian Nguyen, Guillaume Bergthold, Pratiti Bandopadhayay
PDF file - 63K, MYC gene sets enriched in medulloblastoma samples with high expression of MYC isoforms.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43d48a62ae4462bdbb031412e3f3e0f6
https://doi.org/10.1158/1078-0432.22450218.v1
https://doi.org/10.1158/1078-0432.22450218.v1
Autor:
Eliezer M. Van Allen, Jochen H. Lorch, Rameen Beroukhim, Scott L. Carter, Levi A. Garraway, Pasi A. Janne, Tom Thomas, Erik K. Alexander, Fiona M. Fennessy, Thomas C. Lee, Travis I. Zack, Jeremiah A. Wala, Amaro Taylor-Weiner, Francis D. Moore, Matthew A. Nehs, Antonio Calles, Stefan Kraft, Glenn J. Hanna, Justine A. Barletta, Vera A. Paulson, Daniel T. Ruan, William J. Gibson
Purpose: Cancers may resist single-agent targeted therapies when the flux of cellular growth signals is shifted from one pathway to another. Blockade of multiple pathways may be necessary for effective inhibition of tumor growth. We document a case i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::058a37ff7a7629b72ba81b75a2f7eaeb
https://doi.org/10.1158/1078-0432.c.6525329
https://doi.org/10.1158/1078-0432.c.6525329