Výsledky vyhledávání - "William J. Fredericks"

The TERE1 protein interacts with mitochondrial TBL2: Regulation of trans-membrane potential, ROS/RNS and SXR target genes

Autor: S. Bruce Malkowicz, Li-Ping Wang, Yongmu Zheng, Frank J. RauscherIII, Michael L. Nickerson, Howard S. Kruth, William J. Fredericks, Robert J. Lee, Nathaniel J. Fredericks, Huiyi Wang, Hankun Yin, Terry McGarvey, Wayland Hsiao, Jayne S. Weiss

Publikováno v: Journal of Cellular Biochemistry. 114:2170-2187

We originally discovered TERE1 as a potential tumor suppressor protein based upon reduced expression in bladder and prostate cancer specimens and growth inhibition of tumor cell lines/xenografts upon ectopic expression. Analysis of TERE1 (aka UBIAD1)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e5e8ac1245d3e2b7df0c000553a1ec1c
https://doi.org/10.1002/jcb.24567

Zobrazit plný text záznamu

Ectopic expression of the TERE1 (UBIAD1) protein inhibits growth of renal clear cell carcinoma cells: Altered metabolic phenotype associated with reactive oxygen species, nitric oxide and SXR target genes involved in cholesterol and lipid metabolism

Autor: S. B. Malkowicz, John E. Tomaszewski, Nathaniel J. Fredericks, Priti Lal, Hankun Yin, William J. Fredericks, S. Bruce Malkowicz, Raghunath Puthiyaveettil, Frank J. Rauscher

Publikováno v: International Journal of Oncology. 43:638-652

Current studies of the TERE1 (UBIAD1) protein emphasize its multifactorial influence on the cell, in part due to its broad sub-cellular distribution to mitochondria, endoplasmic reticulum and golgi. However, the profound effects of TERE1 relate to it

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::553a5281c7c3707b441fe6628841b188
https://doi.org/10.3892/ijo.2013.1985

Zobrazit plný text záznamu

The Ajuba LIM Domain Protein Is a Corepressor for SNAG Domain–Mediated Repression and Participates in Nucleocytoplasmic Shuttling

Autor: Gregory D. Longmore, Zhaoyuan Hou, Rakesh K. Goyal, Ellen M. Langer, Hongzhuang Peng, Frank J. Rauscher, William J. Fredericks, Kasirajan Ayyanathan

Publikováno v: Cancer Research. 67:9097-9106

The SNAG repression domain is comprised of a highly conserved 21–amino acid sequence, is named for its presence in the Snail/growth factor independence-1 class of zinc finger transcription factors, and is present in a variety of proto-oncogenic tra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e801e5f0b6f4c169c8f2fc8f14d15193
https://doi.org/10.1158/0008-5472.can-07-2987

Zobrazit plný text záznamu

MP47-17 REDUCED TERE1 (UBIAD1) PROTEIN EXPRESSION ASSOCIATES WITH MALIGNANT BUT NOT BENIGN RENAL CANCERS. ECTOPIC TERE1 EXPRESSION INDUCES SXR TARGET GENES REGULATING BONE REMODELING: RELEVANCE TO BONE METASTASIS

Autor: Frank J. Rauscher, Priti Lal, S. Bruce Malkowicz, William J. Fredericks

Publikováno v: Journal of Urology. 193

RESULTS: Stage IV RCC patients exhibiting complete responses to vaccination exhibited a unique monocyte subset signature in pretreatment peripheral blood with approximately twice as many nonclassical monocytes (17.6 0.4, mean SD) compared to partial

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f287561518916f616247fbc28e2eefa2
https://doi.org/10.1016/j.juro.2015.02.1537

Zobrazit plný text záznamu

Drag Reduction Through Distributed Electric Propulsion

Autor: JoeBen Bevirt, Nicholas K. Borer, Mark D. Moore, Alex M. Stoll, William J. Fredericks

Publikováno v: 14th AIAA Aviation Technology, Integration, and Operations Conference.

One promising application of recent advances in electric aircraft propulsion technologies is a blown wing realized through the placement of a number of electric motors driving individual tractor propellers spaced along each wing. This configuration i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::59f9020817d7ed646c095498b1aecb0f
https://doi.org/10.2514/6.2014-2851

Zobrazit plný text záznamu

LIMD2 Is a Small LIM-Only Protein Overexpressed in Metastatic Lesions That Regulates Cell Motility and Tumor Progression by Directly Binding to and Activating the Integrin-Linked Kinase

Publikováno v: Peng, H, Talebzadeh-Farrooji, M, Osborne, M J, Prokop, J W, McDonald, P C, Karar, J, Hou, Z, He, M, Kebebew, E, Orntoft, T, Herlyn, M, Caton, A J, Fredericks, W, Malkowicz, B, Paterno, C S, Carolin, A S, Speicher, D W, Skordalakes, E, Huang, Q, Dedhar, S, Borden, K L B & Rauscher, F J 2014, ' LIMD2 Is a Small LIM-Only Protein Overexpressed in Metastatic Lesions That Regulates Cell Motility and Tumor Progression by Directly Binding to and Activating the Integrin-Linked Kinase ', Cancer Research, vol. 74, no. 5, pp. 1390-403 . https://doi.org/10.1158/0008-5472.CAN-13-1275

Proteins that communicate signals from the cytoskeleton to the nucleus are prime targets for effectors of metastasis as they often transduce signals regulating adhesion, motility, and invasiveness. LIM domain proteins shuttle between the cytoplasm an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::274adf96ad0a1cc557cee619b0e3f3b0
https://europepmc.org/articles/PMC4183205/

Zobrazit plný text záznamu

Regulating the neoplastic phenotype using engineered transcriptional repressors

Autor: Kasirajan Ayyanathan, William J. Fredericks, Frank J. Rauscher

Publikováno v: Cancer Letters. 162:S23-S32

We have applied engineered transcriptional repressors to specifically inhibit disease gene-activated pathways in oncogenesis. We have demonstrated that synthetic repressors combining PAX3 DNA binding domains with different repression domains, KRAB or

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::502467d862df6d35fe03ad31c7e6ae5e
https://doi.org/10.1016/s0304-3835(00)00649-2

Zobrazit plný text záznamu

KAP-1 Corepressor Protein Interacts and Colocalizes with Heterochromatic and Euchromatic HP1 Proteins: a Potential Role for Krüppel-Associated Box–Zinc Finger Proteins in Heterochromatin-Mediated Gene Silencing

Autor: Frank J. Rauscher, Prim B. Singh, David C. Schultz, Kasirajan Ayyanathan, William J. Fredericks, Josh R. Friedman, Robert F. Ryan

Publikováno v: Molecular and Cellular Biology. 19:4366-4378

Krüppel-associated box (KRAB) domains are present in approximately one-third of all human zinc finger proteins (ZFPs) and are potent transcriptional repression modules. We have previously cloned a corepressor for the KRAB domain, KAP-1, which is req

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbe5fee35e70a1749b1a901af9fdf78d
https://doi.org/10.1128/mcb.19.6.4366

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání