Zobrazeno 1 - 10
of 42
pro vyhledávání: '"William J. Drury"'
Autor:
Punit P. Seth, Johan Broddefalk, Patrik U. Andersson, Johan Meuller, Michael E. Østergaard, Thazha P. Prakash, Linda Sundström, Leonardo De Maria, Wuxia Fu, Ahlke Hayen, David Janzén, Carina Ämmälä, Eric Valeur, Laurent Knerr, Maria Ölwegård-Halvarsson, Richard G. Lee, Shalini Andersson, William J. Drury, Elaine Pirie, Mehran Nikan, Rasmus Jansson-Löfmark
Publikováno v:
Journal of the American Chemical Society. 143:3416-3429
The extra hepatic delivery of antisense oligonucleotides (ASOs) remains a challenge and hampers the widespread application of this powerful class of therapeutic agents. In that regard, pancreatic beta cells are a particularly attractive but challengi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b854feb4ca478194b8ccb06db2a2c928
https://doi.org/10.1021/jacs.0c12043
https://doi.org/10.1021/jacs.0c12043
Autor:
Brendon E. Cook, Jonathan Archbold, Khaled Nasr, Sara Girmay, Stanley I. Goldstein, Pei Li, Sivaraman Dandapani, Nathan E. Genung, Sac-Pham Tang, Stuart McClusky, Christophe Plisson, Megan E. Afetian, Chrissa A. Dwyer, Michael Fazio, William J. Drury, Frank Rigo, Laurent Martarello, Maciej Kaliszczak
Publikováno v:
Molecular imaging and biology. 24(6)
The treatment of complex neurological diseases often requires the administration of large therapeutic drugs, such as antisense oligonucleotide (ASO), by lumbar puncture into the intrathecal space in order to bypass the blood-brain barrier. Despite th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43e72f918165f8a07d9d8a09a98a8da8
https://pubmed.ncbi.nlm.nih.gov/35655109
https://pubmed.ncbi.nlm.nih.gov/35655109
Autor:
Ranganath Gopalakrishnan, Anaïs F. M. Noisier, Martin A. Hayes, Lara R. Malins, Magnus Johansson, William J. Drury, Eric Valeur, Laurent Knerr
Publikováno v:
Angewandte Chemie. 131:19272-19278
The late-stage functionalization (LSF) of peptides represents a valuable strategy for the design of potent peptide pharmaceuticals by enabling rapid exploration of chemical diversity and offering novel opportunities for peptide conjugation. While the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::075503324188482e802a84db634108cb
https://doi.org/10.1002/ange.201910888
https://doi.org/10.1002/ange.201910888
Autor:
Anderson, Brooke A, Freestone, Graeme C, Low, Audrey, De-Hoyos, Cheryl L, III, William J Drury, Østergaard, Michael E, Migawa, Michael T, Fazio, Michael, Wan, W Brad, Berdeja, Andres, Scandalis, Eli, Burel, Sebastien A, Vickers, Timothy A, Crooke, Stanley T, Swayze, Eric E, Liang, Xuehai, Seth, Punit P
Publikováno v:
Nucleic Acids Research; 9/20/2021, Vol. 49 Issue 16, p9026-9041, 16p
Autor:
Patrik U. Andersson, C. Wennberg-Huldt, Eva-Marie Andersson, Carina Ämmälä, Eric Valeur, Thazha P. Prakash, Punit P. Seth, Camilla Johansson, Laurent Knerr, Johan Meuller, Richard G. Lee, Linda Sundström, P. Stillemark-Billton, Shalini Andersson, Brett P. Monia, I. Ahlstedt, J. Claesson, William J. Drury, David Janzén, Rasmus Jansson-Löfmark
Publikováno v:
Science Advances
Receptor-dependent productive uptake of GLP1-conjugated antisense oligonucleotides occurs selectively in pancreatic β-cells.
Antisense oligonucleotide (ASO) silencing of the expression of disease-associated genes is an attractive novel therapeu
Antisense oligonucleotide (ASO) silencing of the expression of disease-associated genes is an attractive novel therapeu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8220e0cf4a2edd82db4488157da1affb
http://europepmc.org/articles/PMC6192685
http://europepmc.org/articles/PMC6192685
Autor:
William J. Drury, Ryan Casey, Michiel Vermeulen, Roberto Bonasio, Zuo-Fei Yuan, Pascal W. T. C. Jansen, David B. Beck, Varun Narendra, Benjamin A. Garcia
Publikováno v:
Journal of Proteome Research
Journal of Proteome Research, 13, 12, pp. 6135-43
Journal of Proteome Research, 13, 6135-43
Journal of Proteome Research, 13, 12, pp. 6135-43
Journal of Proteome Research, 13, 6135-43
Accurate and sensitive detection of protein–protein and protein–RNA interactions is key to understanding their biological functions. Traditional methods to identify these interactions require cell lysis and biochemical manipulations that exclude
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b2f83657b1da99530a04cf38f1ae3cb
http://europepmc.org/articles/PMC4261942
http://europepmc.org/articles/PMC4261942
Publikováno v:
Journal of medicinal chemistry. 59(21)
Over the past decade, foldamers have progressively emerged as useful architectures to mimic secondary structures of proteins. Peptidic foldamers, consisting of various amino acid based backbones, have been the most studied from a therapeutic perspect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ed87d892efeba135c517ad42d7eadff
https://pubmed.ncbi.nlm.nih.gov/27362955
https://pubmed.ncbi.nlm.nih.gov/27362955
Autor:
Ananya Majumdar, Robert J. Cotter, William J. Drury, Beverley M. Dancy, Yan Sun, Christine A. Jelinek, Philip A. Cole, Romeo Papazyan, Shonoi Ming, Blair C. R. Dancy, Sean D. Taverna
Publikováno v:
Journal of the American Chemical Society. 134:5138-5148
Reversible lysine acetylation and methylation regulate the function of a wide variety of proteins, including histones. Here, we have synthesized azalysine-containing peptides in acetylated and unacetylated forms as chemical probes of the histone deac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1234c6b306b13b4f4d760dc4d74ad571
https://doi.org/10.1021/ja209574z
https://doi.org/10.1021/ja209574z
Autor:
William J. Drury, Mary Katherine Tarrant, Vedangi Sample, Philip A. Cole, Jin Zhang, Lawrence M. Szewczuk
Publikováno v:
Biochemistry. 47:10407-10419
Melatonin is a key circadian rhythm hormone that is produced in a diurnal pattern, driven by changes in the level of the biosynthetic enzyme serotonin N-acetyltransferase [arylalkylamine N-acetyltransferase (AANAT)]1 (1, 2). The neuroendocrine networ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11fea474c67b67e7ccc4a8bbf4904dbe
https://doi.org/10.1021/bi801189d
https://doi.org/10.1021/bi801189d
Autor:
William J. Drury, Andreas Pfaltz
Publikováno v:
Proceedings of the National Academy of Sciences. 101:5723-5726
For a long time, C 2 -symmetric ligands have dominated in asymmetric catalysis. More recently, nonsymmetrical modular P,N-ligands have been introduced. These ligands have been applied successfully in various metal-catalyzed reactions and, in many cas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57196816d3b820d760342216a1813339
https://doi.org/10.1073/pnas.0307152101
https://doi.org/10.1073/pnas.0307152101