Zobrazeno 1 - 10
of 15
pro vyhledávání: '"William J. Blake"'
Autor:
Elizabeth A. Phillips, Adam D. Silverman, Aric Joneja, Michael Liu, Carl Brown, Paul Carlson, Christine Coticchia, Kristen Shytle, Alex Larsen, Nadish Goyal, Vincent Cai, Jason Huang, Jennifer E. Hickey, Emily Ryan, Joycelynn Acheampong, Pradeep Ramesh, James J. Collins, William J. Blake
This protocol defines the process for executing an INSPECTR assay to sensitively detect SARS-CoV-2 gRNA in a fully ambient temperature workflow. INSPECTR (for internal splint-pairing expression-cassette translation reaction), leverages the target-spe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0b8daa3e8889c9c5a79fe1639cfd51d2
https://doi.org/10.21203/rs.3.pex-2197/v1
https://doi.org/10.21203/rs.3.pex-2197/v1
Autor:
Elizabeth A. Phillips, Adam D. Silverman, Aric Joneja, Michael Liu, Carl Brown, Paul Carlson, Christine Coticchia, Kristen Shytle, Alex Larsen, Nadish Goyal, Vincent Cai, Jason Huang, Jennifer E. Hickey, Emily Ryan, Joycelynn Acheampong, Pradeep Ramesh, James J. Collins, William J. Blake
Publikováno v:
Nature Biomedical Engineering.
Nucleic acid assays are not typically deployable in point-of-care settings because they require costly and sophisticated equipment for the control of the reaction temperature and for the detection of the signal. Here we report an instrument-free assa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4a006f7b37d30729ac007a0886b5012c
https://doi.org/10.1038/s41551-023-01028-y
https://doi.org/10.1038/s41551-023-01028-y
Autor:
Jennifer M. Pena, Brendan J. Manning, Xiang Li, Elizabeth S. Fiore, Leah Carlson, Kristen Shytle, Peter P. Nguyen, Ishara Azmi, Alex Larsen, Mary K. Wilson, Subha Singh, Marisa C. DeMeo, Pradeep Ramesh, Heike Boisvert, William J. Blake
Publikováno v:
The Journal of Molecular Diagnostics.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d1cc395c06df0f0fc63e86a24007aad2
https://doi.org/10.1016/j.jmoldx.2023.03.009
https://doi.org/10.1016/j.jmoldx.2023.03.009
Publikováno v:
mBio, Vol 15, Iss 10 (2024)
ABSTRACT High-risk human papillomavirus (HPV) oncoproteins inactivate cellular tumor suppressors to reprogram host cell signaling pathways. HPV E7 proteins bind and degrade the tumor suppressor PTPN14, thereby promoting the nuclear localization of th
Externí odkaz:
https://doaj.org/article/3ac950327bc74d55a5d29001a0f35c0c
Autor:
Hannah J Thompson, Marisa C Tudino, Wahab A. Khan, Subha Singh, Heike Boisvert, Rachael E Barney, Elizabeth S Fiore, William J Blake, Gregory J. Tsongalis, Mary K Wilson, Jennifer M Peña, Brendan J Manning, Joel A Mowatt
Publikováno v:
Clinical chemistry. 68(1)
Background The ability to control the spread of COVID-19 continues to be hampered by a lack of rapid, scalable, and easily deployable diagnostic solutions. Methods We developed a diagnostic method based on CRISPR (clustered regularly interspaced shor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a3aabaa7583d393480653b09b3073d7
https://pubmed.ncbi.nlm.nih.gov/34718481
https://pubmed.ncbi.nlm.nih.gov/34718481
Autor:
Dmitri Volfson, Jennifer Marciniak, William J. Blake, Natalie Ostroff, Lev S. Tsimring, Jeff Hasty
Publikováno v:
Nature. 439:861-864
Summary form only given. Variable gene expression within a clonal population of cells has been implicated in a number of important processes including mutation and evolution, determination of cell fates and the development of genetic disease. Recent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25fc383461210d580eeb494fa4641499
https://doi.org/10.1038/nature04281
https://doi.org/10.1038/nature04281
Publikováno v:
mSphere, Vol 7, Iss 3 (2022)
ABSTRACT The pathogenesis of Toxoplasma gondii is mainly due to tissue damage caused by the repeating lytic cycles of the parasite. Many proteins localized to the pellicle of the parasite, particularly kinases, have been identified as critical regula
Externí odkaz:
https://doaj.org/article/088c045ec3e04f4a86bba2431e80aa19
Publikováno v:
Science (New York, N.Y.). 307(5717)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ceacdd30800f00147d3cbcd7230931a2
https://pubmed.ncbi.nlm.nih.gov/15790857
https://pubmed.ncbi.nlm.nih.gov/15790857
Publikováno v:
mSphere, Vol 5, Iss 1 (2020)
ABSTRACT During host cell invasion, the eukaryotic pathogen Toxoplasma gondii forms a parasitophorous vacuole to safely reside within the cell, while it is partitioned from host cell defense mechanisms. From within this safe niche, parasites sabotage
Externí odkaz:
https://doaj.org/article/0ae5a106e4684bbc8fd846b7dd46a6c6
Publikováno v:
American Journal of Clinical Pathology. 48:104-126
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40d4f4b1ce93f1e77075b9d758e9f7d9
https://doi.org/10.1093/ajcp/48.1.104
https://doi.org/10.1093/ajcp/48.1.104