Zobrazeno 1 - 10
of 79
pro vyhledávání: '"William J. Ball"'
Autor:
Kemin Tan, Nassif Tabaja, William J. Ball, Angela J. Ahrendt, Andrew B. Norman, M. Zhou, Terence L. Kirley, Rosemarie Wilton, Andrzej Joachimiak, P.R. Pokkuluri, N. E. C. Duke, Marianne Schiffer
Publikováno v:
Acta Crystallogr F Struct Biol Commun
A high-affinity anti-cocaine monoclonal antibody, designated h2E2, is entering phase 1 clinical trials for cocaine abuse therapy. To gain insight into the molecular details of its structure that are important for binding cocaine and cocaine metabolit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64fb51ae472beca13ec3cd2a157550b9
https://pubmed.ncbi.nlm.nih.gov/31702583
https://pubmed.ncbi.nlm.nih.gov/31702583
Publikováno v:
International Immunopharmacology. 23:387-390
The chimeric human/mouse anti-cocaine monoclonal antibody (mAb) 2E2 and its further humanized variant h2E2 have been reported to sequester a significant portion of cocaine in plasma and decrease cocaine concentrations in the brain in mice and rats. H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cee43602e2dc1ba1826184b15d216fa
https://doi.org/10.1016/j.intimp.2014.10.025
https://doi.org/10.1016/j.intimp.2014.10.025
Autor:
Andrew B. Norman, Fatima O. Saeed, Terence L. Kirley, William J. Ball, Rose P. Webster, Hanna N. Wetzel
We have generated a humanized anti-cocaine monoclonal antibody (mAb), which is at an advanced stage of pre-clinical development. We report here in vitro binding affinity studies, and in vivo pharmacokinetic and efficacy studies of the recombinant mAb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09e8112c527ca79521d29423809ca6a0
https://europepmc.org/articles/PMC5560619/
https://europepmc.org/articles/PMC5560619/
Autor:
Christopher Wanitshka, William J. Ball
Publikováno v:
Local Environment. 21:24-38
We present the first systematic research on green fairs in the USA. We provide a summary analysis of the frequency, trends, goals, structure, and operations of green fairs being held in the USA. We also present an initial assessment of their potentia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e7fa017f55290fb8415f6dbceee4f121
https://doi.org/10.1080/13549839.2014.914900
https://doi.org/10.1080/13549839.2014.914900
Publikováno v:
Drug Metabolism and Disposition. 42:1125-1131
The monoclonal antibody (mAb), h2E2, is a humanized version of the chimeric human/murine anti-cocaine mAb 2E2. The recombinant h2E2 protein was produced in vitro from a transfected mammalian cell line and retained high affinity (4 nM Kd) and specific
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9fd5142ddbfe658fe6643a326c0d01ee
https://doi.org/10.1124/dmd.114.057034
https://doi.org/10.1124/dmd.114.057034
Autor:
William J. Ball, Andrew B. Norman
Publikováno v:
Immunotherapy. 4:335-343
The effects of a humanized monoclonal antibody (mAb) having high affinity and specificity for cocaine in animal models are reviewed. The mAb reduced the concentration of cocaine in the brain of mice after intravenous injection of cocaine. In addition
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4770b4607607351163d62c30c713b3a3
https://doi.org/10.2217/imt.12.19
https://doi.org/10.2217/imt.12.19
Publikováno v:
Biologics to Treat Substance Use Disorders ISBN: 9783319231495
The use of an anti-cocaine monoclonal antibody (mAb) is similar to the concept of cocaine vaccines, discussed elsewhere in this book. Although vaccines have many advantages as an immunotherapy for cocaine abuse, the use of anti-cocaine mAbs addresses
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::848aa188e0f9e2adfff678cb3b40286d
https://doi.org/10.1007/978-3-319-23150-1_8
https://doi.org/10.1007/978-3-319-23150-1_8
Autor:
William J. Ball
Publikováno v:
Journal of Political Science Education. 5:198-213
The focus of the paper is on the transformative effect on student learning and engagement that results from using contemporary Geographic Information Systems (GIS) tools and directed reflection to engage in spatial learning about the politics (litera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7b4adf6e9b0b5d20c4b6d9611fa12808
https://doi.org/10.1080/15512160903035633
https://doi.org/10.1080/15512160903035633
Autor:
William J. Ball, Mantana K. Norman, William R. Buesing, Amadeo J. Pesce, Andrew B. Norman, Michael R. Tabet
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 320:145-153
The predominantly human sequence, high-affinity anticocaine monoclonal antibody (mAb) 2E2 was cleared slowly from mouse blood by a first-order process with an elimination t 1/2 of 8.1 days. Infused 2E2 also produced a dramatic dose-dependent increase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15bd3a7d28ece783ac382a9b57bf9010
https://doi.org/10.1124/jpet.106.111781
https://doi.org/10.1124/jpet.106.111781
Publikováno v:
Proteins: Structure, Function, and Bioinformatics. 60:382-391
The amino acid sequences of the heavy- and light-chain variable regions of the high-affinity human sequence antidigoxin monoclonal antibody 1B3 (mAb 1B3) were determined, and a structural model for the mAb's variable region was developed by homology
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e230c8fba5d3fdb571999b40fc63576
https://doi.org/10.1002/prot.20484
https://doi.org/10.1002/prot.20484