Zobrazeno 1 - 10
of 112
pro vyhledávání: '"William J. Moore"'
Autor:
Kevin B. Teuscher, Somenath Chowdhury, Kenneth M. Meyers, Jianhua Tian, Jiqing Sai, Mayme Van Meveren, Taylor M. South, John L. Sensintaffar, Tyson A. Rietz, Soumita Goswami, Jing Wang, Brian C. Grieb, Shelly L. Lorey, Gregory C. Howard, Qi Liu, William J. Moore, Gordon M. Stott, William P. Tansey, Taekyu Lee, Stephen W. Fesik
Publikováno v:
Proceedings of the National Academy of Sciences. 120
WD repeat domain 5 (WDR5) is a core scaffolding component of many multiprotein complexes that perform a variety of critical chromatin-centric processes in the nucleus. WDR5 is a component of the mixed lineage leukemia MLL/SET complex and localizes MY
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f55525b23552d424473dfa053dbc6302
https://doi.org/10.1073/pnas.2211297120
https://doi.org/10.1073/pnas.2211297120
Autor:
Rachel Medernach, William J Moore, Sophia Nozick, Maha M Alamri, Kendall Kling, Michael G Ison, Qi Chao, Kelly E R Bachta, Nathaniel J Rhodes, Egon A Ozer, Alan R Hauser
Publikováno v:
Open Forum Infectious Diseases. 9
Background Cefiderocol (FDC) is a novel antimicrobial agent used for multi-drug resistant Gram-negative pathogens. To date, reports of mutations in β-lactamase and siderophore complex genes have been described and may contribute to FDC resistance. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::743f5be7fda700737f726485f25d2189
https://doi.org/10.1093/ofid/ofac492.217
https://doi.org/10.1093/ofid/ofac492.217
Autor:
Radhika S Polisetty, Brian M Hoff, William J Moore, Michael Postelnick, Sheila K Wang, Teresa Zembower, Qi Chao, Michael Malczynski, Grace Barajas, Christina Silkaitis, Asra Salim, Jaime Borkowski, Rishita Shah, Andrea Quinn, Kyle Johnicker, Charlene Liang, Stephanie Chang, Sarah H Sutton
Publikováno v:
Open Forum Infectious Diseases. 9
Background Distinguishing true Clostridioides difficile Infection (CDI) from colonization is a challenge, with nearly 20% of hospitalized adults being carriers of C. difficile. Polymerase chain reaction (PCR) testing alone is not able to distinguish
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::68ee821f114ddfb2d36f69f64cf1869d
https://doi.org/10.1093/ofid/ofac492.258
https://doi.org/10.1093/ofid/ofac492.258
Autor:
Hongchao Zheng, Andrew L. McIver, Surendra Karavadhi, Adam Yasgar, William J. Moore, Li Liu, Zhuyin Li, Carleen Klumpp-Thomas, Ajit Jadhav, Natalia J. Martinez, Kyle R. Brimacombe, Mindy I. Davis, Wei Zhao, Daniel J. Urban, Stephen V. Frye, Anton Simeonov, Xiaodong Wang, Samarjit Patnaik, Rajan Pragani, Mark J. Henderson, Weihe Zhang, Melinda G. Hollingshead, Min Shen, Qingyang Liu, Gordon M. Stott, Tobie D. Lee, Sam Michael, Matthew B. Boxer, Jason M. Rohde, Matthew D. Hall, Yuhong Fang, Joseph M. Covey, Dorian M. Cheff
Publikováno v:
J Med Chem
Neomorphic mutations in isocitrate dehydrogenase 1 (IDH1) are oncogenic for a number of malignancies, primarily low-grade gliomas and acute myeloid leukemia (AML). We report a medicinal chemistry campaign around a 7,7-dimethyl-7,8-dihydro-2H-1λ(2)-q
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d6c4e845279737db3495a9974e39ba7
https://doi.org/10.1021/acs.jmedchem.1c00019
https://doi.org/10.1021/acs.jmedchem.1c00019
Autor:
Kevin B. Teuscher, Kenneth M. Meyers, Qiangqiang Wei, Jonathan J. Mills, Jianhua Tian, Joseph Alvarado, Jiqing Sai, Mayme Van Meveren, Taylor M. South, Tyson A. Rietz, Bin Zhao, William J. Moore, Gordon M. Stott, William P. Tansey, Taekyu Lee, Stephen W. Fesik
Publikováno v:
J Med Chem
WD repeat domain 5 (WDR5) is a nuclear scaffolding protein that forms many biologically important multiprotein complexes. The WIN site of WDR5 represents a promising pharmacological target in a variety of human cancers. Here, we describe the optimiza
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c2f5a7ab4df4676d1a03a352d9f2c08
https://pubmed.ncbi.nlm.nih.gov/35436124
https://pubmed.ncbi.nlm.nih.gov/35436124
Autor:
Nicholas Rebold, Taylor Morrisette, Abdalhamid M Lagnf, Sara Alosaimy, Dana Holger, Katie Barber, Julie Ann Justo, Kayla Antosz, Travis J Carlson, Jeremy J Frens, Mark Biagi, Wesley D Kufel, William J Moore, Nicholas Mercuro, Brian R Raux, Michael J Rybak
Publikováno v:
Open Forum Infectious Diseases
A multicenter case series of 21 patients were treated with imipenem-cilastatin-relebactam. There were mixed infection sources, with pulmonary infections (11/21,52%) composing the majority. The primary pathogen was Pseudomonas aeruginosa (16/21, 76%),
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::966d078d9d00bf0239e9160b42272002
https://pubmed.ncbi.nlm.nih.gov/34901302
https://pubmed.ncbi.nlm.nih.gov/34901302
Autor:
Jianhua Tian, Kevin B. Teuscher, Erin R. Aho, Joseph R. Alvarado, Jonathan J. Mills, Kenneth M. Meyers, Rocco D. Gogliotti, Changho Han, Jonathan D. Macdonald, Jiqing Sai, J. Grace Shaw, John L. Sensintaffar, Bin Zhao, Tyson A. Rietz, Lance R. Thomas, William G. Payne, William J. Moore, Gordon M. Stott, Jumpei Kondo, Masahiro Inoue, Robert J. Coffey, William P. Tansey, Shaun R. Stauffer, Taekyu Lee, Stephen W. Fesik
Publikováno v:
Journal of Medicinal Chemistry. 63:656-675
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::40dc8f49d750829b0bd7b963329455df
https://doi.org/10.1021/acs.jmedchem.9b01608
https://doi.org/10.1021/acs.jmedchem.9b01608
Autor:
Trevor Manz, Josh Moore, Chris Allan, Christian Tischer, William J. Moore, Dominik Lindner, Sébastien Besson, Erin Diel, Melissa Linkert, Jason R. Swedlow, Kevin Kozlowski, David Gault, Constantin Pape, Jean-Marie Burel
Publikováno v:
Nature Methods
The rapid pace of innovation in biological imaging and the diversity of its applications have prevented the establishment of a community-agreed standardized data format. We propose that complementing established open formats such as OME-TIFF and HDF5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da4c229e32355e1240adaea6042f89a9
https://pubmed.ncbi.nlm.nih.gov/34845388
https://pubmed.ncbi.nlm.nih.gov/34845388
Autor:
Douglas R. Davies, Gloria A. Benavides, Xin Hu, Jeffrey P. Norenberg, Somnath Jana, Ganesha Rai, Pavan Muttil, Larry A. Sklar, Katherine Pohida, Daniel J. Urban, Kabir, David M. Dranow, Andrew J. Flint, Leonard M. Neckers, Giuseppe L. Squadrito, David J. Maloney, William J. Moore, Victor M. Darley-Usmar, Elias C. Padilha, Ajit Jadhav, Matthew D. Hall, Kyle R. Brimacombe, Dorian M. Cheff, Anton Simeonov, Nitesh K. Kunda, Plamen P. Christov, Pranav Shah, Tamara Anderson, Dingyin Tao, Hu Zhu, Murali Cherukuri, Yuhong Fang, Shyh-Ming Yang, Gary A. Sulikowski, Gordon M. Stott, Donna F. Kusewitt, Tobie D. Lee, Chi V. Dang, Alex G. Waterson, Mark J. Henderson, Bryan T. Mott, Kwangho Kim, Michelle S. Johnson, Helen J. Hathaway, Nobu Oshima
Publikováno v:
J Med Chem
Lactate dehydrogenase (LDH) catalyzes the conversion of pyruvate to lactate, with concomitant oxidation of reduced nicotinamide adenine dinucleotide as the final step in the glycolytic pathway. Glycolysis plays an important role in the metabolic plas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81b11cff4db96920574f1004df1f63c0
https://pubmed.ncbi.nlm.nih.gov/32902275
https://pubmed.ncbi.nlm.nih.gov/32902275
Autor:
R. Jeffrey Neitz, Zhizhou Yue, Neal Jeffrey Green, Shan Li, Stacie L. Bulfer, Tsui-Fen Chou, Raffaele Colombo, James C. Burnett, Matthew G. LaPorte, Peter Wipf, Donna M. Huryn, Michelle R. Arkin, Celeste Alverez, William J. Moore
Publikováno v:
ACS medicinal chemistry letters, vol 9, iss 11
ACS Medicinal Chemistry Letters
ACS Medicinal Chemistry Letters
Optimization of the side-chain of a phenyl indole scaffold identified from a high-throughput screening campaign for inhibitors of the AAA+ ATPase p97 is reported. The addition of an N-alkyl piperazine led to high potency of this series in a biochemic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08a97309d2f36bd3f55226152fc25aff
https://doi.org/10.1021/acsmedchemlett.8b00372
https://doi.org/10.1021/acsmedchemlett.8b00372