Zobrazeno 1 - 9
of 9
pro vyhledávání: '"William J. Frazee"'
Autor:
Hildegard C. Eliason, Stephen A. Fakhoury, William J. Frazee, Steven M. Riddle, Bryan D. Marks
Publikováno v:
SLAS Discovery. 16:1247-1253
Developing molecularly targeted therapeutics with minimal off-target effects is facilitated by an understanding of compound selectivity. However, for HDAC inhibitors, a clear understanding of specificity has been challenging. In particular, it has be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32ae812ddd8ee17f996ef878fdf0bad0
https://doi.org/10.1177/1087057111422102
https://doi.org/10.1177/1087057111422102
Autor:
Sunita J. Shukla, Anton Simeonov, James Inglese, William J. Frazee, John Printen, Hildegard C. Eliason, Ryan MacArthur, Christopher P. Austin, Bryan D. Marks, Tina M. Hallis, Douglas S. Auld, Upinder Singh, Dac-Trung Nguyen
The human pregnane X nuclear receptor (PXR) is a xenobiotic-regulated receptor that is activated by a range of diverse chemicals, including antibiotics, antifungals, glucocorticoids, and herbal extracts. PXR has been characterized as an important rec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5a71bbfd9868b23ee45e6e3cee5ecf0
https://europepmc.org/articles/PMC3116688/
https://europepmc.org/articles/PMC3116688/
Publikováno v:
Cancer Research. 70:362-362
There is a great clinical need to develop selective, high affinity kinase inhibitors. While many high throughput kinase activity assays have become readily available, easy-to-use and cost-effective, activity-based assays have significant limitations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f24f06ad45fd40985c014a595ecd6bc9
https://doi.org/10.1158/1538-7445.am10-362
https://doi.org/10.1158/1538-7445.am10-362
Autor:
Sunita J. Shukla, Dac-Trung Nguyen, Ryan MacArthur, Anton Simeonov, William J. Frazee, Tina M. Hallis, Bryan D. Marks, Upinder Singh, Hildegard C. Eliason, John Printen, Christopher P. Austin, James Inglese, Douglas S. Auld
Publikováno v:
Assay & Drug Development Technologies; Apr2009, Vol. 7 Issue 2, p143-169, 27p
Publikováno v:
Tetrahedron. 40:1333-1343
Reduction of the previously prepared1 chiral 2-acyl-l,3-oxathianes derived from (+)-pulegone with various metal hydride combinations proceeds stereoselectively, with diastereomer excess (d.e.) of as much as 97% in the case of reduction of phenyl keto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ac18cd6e192e96d6fb789c7288496829
https://doi.org/10.1016/s0040-4020(01)82419-4
https://doi.org/10.1016/s0040-4020(01)82419-4
Publikováno v:
The Journal of Organic Chemistry. 36:2855-2859
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bff0ed8e151a1c965132a13023204198
https://doi.org/10.1021/jo00818a028
https://doi.org/10.1021/jo00818a028
Autor:
Ernest L. Eliel, William J. Frazee
Publikováno v:
The Journal of Organic Chemistry. 44:3598-3599
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b794bfa0ab0141be057ae8a95a2a54d5
https://doi.org/10.1021/jo01334a039
https://doi.org/10.1021/jo01334a039