Zobrazeno 1 - 10
of 75
pro vyhledávání: '"William J Watkins"'
Autor:
Sarah E Boyce, Neeraj Tirunagari, Anita Niedziela-Majka, Jason Perry, Melanie Wong, Elaine Kan, Leanna Lagpacan, Ona Barauskas, Magdeleine Hung, Martijn Fenaux, Todd Appleby, William J Watkins, Uli Schmitz, Roman Sakowicz
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e84808 (2014)
Elucidation of the mechanism of action of the HCV NS5B polymerase thumb site II inhibitors has presented a challenge. Current opinion holds that these allosteric inhibitors stabilize the closed, inactive enzyme conformation, but how this inhibition i
Externí odkaz:
https://doaj.org/article/511db7137be1485baa683530d590daed
Autor:
Awen Gallimore, Andrew Godkin, Robert Andrews, William J. Watkins, Matthew J. Smalley, Rhiannon French, James P. Hindley, Howard Kendrick, Stefan Milutinovic, Michelle Somerville, Sarah N. Lauder, Kathryn Smart, Emma Jones, Alexander Greenshields-Watson, Ana Pires
Supplementary Figures 1-8
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d486884604d87cab99475a87091a408
https://doi.org/10.1158/2326-6066.22543605.v1
https://doi.org/10.1158/2326-6066.22543605.v1
Autor:
Awen Gallimore, Andrew Godkin, Robert Andrews, William J. Watkins, Matthew J. Smalley, Rhiannon French, James P. Hindley, Howard Kendrick, Stefan Milutinovic, Michelle Somerville, Sarah N. Lauder, Kathryn Smart, Emma Jones, Alexander Greenshields-Watson, Ana Pires
The nature of the tumor microenvironment (TME) influences the ability of tumor-specific T cells to control tumor growth. In this study, we performed an unbiased comparison of the TME of regulatory T-cell (Treg)–replete and Treg-depleted carcinogen-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2dd1b36ae44d938b2dc48a4d25e36406
https://doi.org/10.1158/2326-6066.c.6550332
https://doi.org/10.1158/2326-6066.c.6550332
Autor:
Rebecca Milton, David Gillespie, Calie Dyer, Khadijeh Taiyari, Maria J Carvalho, Kathryn Thomson, Kirsty Sands, Edward A R Portal, Kerenza Hood, Ana Ferreira, Thomas Hender, Nigel Kirby, Jordan Mathias, Maria Nieto, William J Watkins, Delayehu Bekele, Mahlet Abayneh, Semaria Solomon, Sulagna Basu, Ranjan K Nandy, Bijan Saha, Kenneth Iregbu, Fatima Z Modibbo, Stella Uwaezuoke, Rabaab Zahra, Haider Shirazi, Syed U Najeeb, Jean-Baptiste Mazarati, Aniceth Rucogoza, Lucie Gaju, Shaheen Mehtar, Andre N H Bulabula, Andrew C Whitelaw, Timothy R Walsh, Grace J Chan, Oludare Odumade, Rozina Ambachew, Zenebe Gebre Yohannes, Gesit Metaferia, Redeat Workneh, Tefera Biteye, Yahya Zekaria Mohammed, Alula M Teklu, Balkachew Nigatu, Wendimagegn Gezahegn, Partha Sarathi Chakravorty, Sharmi Naha, Anuradha Mukherjee, Khairiyya Muhammad Umar, Asunugwo Vivian Akunna, Queen Nsude, Ifeoma Uke, Mary-Joe Okenu, Chinenye Akpulu, Chukwuemeka Mmadueke, Samuel Yakubu, Lamidi Audu, Nura Idris, Safiya Gambo, Jamila Ibrahim, Edwin Chinago, Ashiru Yusuf, Shamsudden Gwadabe, Adeola Adeleye, Muhammad Aliyu, Amina Muhammad, Aishatu Kassim, Aisha Sani Mukaddas, Rashida Yakubu Khalid, Fatima Ibrahim Alkali, Maryam Yahaya Muhammad, Fatima Muhammad Tukur, Surayya Mustapha Muhammad, Adeola Shittu, Murjanatu Bello, Fatima Habib Sa ad, Shaheed Zulfiqar, Adil Muhammad, Muhammad Hilal Jan, Lauren Paterson
Background\udNeonatal sepsis is a primary cause of neonatal mortality and is an urgent global health concern, especially within low-income and middle-income countries (LMICs), where 99% of global neonatal mortality occurs. The aims of this study were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90cec59aff3258d66c0750e53f6f1f57
https://orca.cardiff.ac.uk/id/eprint/149183/1/PIIS2214109X22000432.pdf
https://orca.cardiff.ac.uk/id/eprint/149183/1/PIIS2214109X22000432.pdf
Autor:
Argiris Asderakis, Tarique K. Sabah, William J. Watkins, Usman Khalid, Laszlo Szabo, Michael R. Stephens, Sian Griffin, Rafael Chavez
Publikováno v:
Kidney international reports. 7(4)
Introduction\ud3C, a study comparing alemtuzumab versus basiliximab induction immunosuppression in kidney transplants has shown lower acute rejection rate with alemtuzumab but same graft survival. Aim of the current study is to examine the effect of
Autor:
Brekhna, Hassan, Muhammad, Ijaz, Asadullah, Khan, Kirsty, Sands, Georgios-Ion, Serfas, Liam, Clayfield, Maisra Mohammed, El-Bouseary, Giulia, Lai, Edward, Portal, Afifah, Khan, William J, Watkins, Julian, Parkhill, Timothy R, Walsh
Publikováno v:
Nature microbiology. 6(10)
Understanding how multidrug-resistant Enterobacterales (MDRE) are transmitted in low- and middle-income countries (LMICs) is critical for implementing robust policies to curb the increasing burden of antimicrobial resistance (AMR). Here, we analysed
Autor:
Markus Peck-Radosavljevic, William J. Watkins, John T. Liles, Thomas Reiberger, Grant R. Budas, Ksenia Brusilovskaya, Eva Hambruch, Philipp Schwabl, Michael Burnet, Claus Kremoser, David G. Breckenridge, Philipp Königshofer, Manfred Birkel, Michael Trauner, P Supper
Publikováno v:
Biomedicines
Volume 9
Issue 1
Biomedicines, Vol 9, Iss 60, p 60 (2021)
Volume 9
Issue 1
Biomedicines, Vol 9, Iss 60, p 60 (2021)
Background: The farnesoid X receptor (FXR) influences hepatic metabolism, inflammation and liver fibrosis as key components of non-alcoholic steatohepatitis (NASH). We studied the effects of the non-steroidal FXR agonist cilofexor (formerly GS-9674)
Autor:
Emma Jones, Rhiannon French, William J. Watkins, Matthew J. Smalley, Alexander Greenshields-Watson, James P. Hindley, Awen Gallimore, Sarah N. Lauder, Michelle Somerville, Robert Andrews, Andrew James Godkin, Kathryn Smart, Stefan Milutinovic, Ana Pires, Howard Kendrick
Publikováno v:
Cancer Immunol Res
The nature of the tumor microenvironment (TME) influences the ability of tumor-specific T cells to control tumor growth. In this study, we performed an unbiased comparison of the TME of regulatory T-cell (Treg)–replete and Treg-depleted carcinogen-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c12cfa716e73b409f397bccf382eb36
https://europepmc.org/articles/PMC7611107/
https://europepmc.org/articles/PMC7611107/
Discovery of Potent and Selective MTH1 Inhibitors for Oncology: Enabling Rapid Target (In)Validation
Autor:
Julie Farand, Jeffrey E. Kropf, Peter Blomgren, Jianjun Xu, Aaron C. Schmitt, Zachary E. Newby, Ting Wang, Eisuke Murakami, Ona Barauskas, Jawahar Sudhamsu, Joy Y. Feng, Anita Niedziela-Majka, Brian E. Schultz, Karen Schwartz, Serge Viatchenko-Karpinski, Dmytro Kornyeyev, Adam Kashishian, Peidong Fan, Xiaowu Chen, Eric B. Lansdon, Michael O. Ports, Kevin S. Currie, William J. Watkins, Gregory T. Notte
Publikováno v:
ACS Med Chem Lett
[Image: see text] We describe the discovery of three structurally differentiated potent and selective MTH1 inhibitors and their subsequent use to investigate MTH1 as an oncology target, culminating in target (in)validation. Tetrahydronaphthyridine 5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a8664fe5cf60201d9c5d872c2fbdf25
https://europepmc.org/articles/PMC7074220/
https://europepmc.org/articles/PMC7074220/
Autor:
William J. Watkins
Publikováno v:
Topics in Medicinal Chemistry ISBN: 9783030282066
The HCV polymerase NS5B is susceptible to allosteric inhibition at four sites that have been exploited by compounds that have shown clinical efficacy. The history of the discovery and optimization of leads acting at each of these sites is discussed.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5848abdf44a8b4a246832b651545ffd7
https://doi.org/10.1007/7355_2018_35
https://doi.org/10.1007/7355_2018_35