Zobrazeno 1 - 10
of 52
pro vyhledávání: '"William J Placzek"'
Autor:
Anna McGriff, William J Placzek
Publikováno v:
PLoS ONE, Vol 18, Iss 1, p e0277726 (2023)
B-cell lymphoma 2 (Bcl-2) proteins are central, conserved regulators of apoptosis. Bcl-2 family function is regulated by binding interactions between the Bcl-2 homology 3 (BH3) motif in pro-apoptotic family members and the BH3 binding groove found in
Externí odkaz:
https://doaj.org/article/4f9e9b8783324ff5adc457d09f835e8a
Autor:
Sindhu Nair, Hoa Q Trummell, Rajani Rajbhandari, Nanda K Thudi, Susan E Nozell, Jason M Warram, Christopher D Willey, Eddy S Yang, William J Placzek, James A Bonner, Markus Bredel
Publikováno v:
PLoS ONE, Vol 15, Iss 2, p e0229077 (2020)
Epidermal growth factor receptor (EGFR) is a pro-tumorigenic receptor tyrosine kinase that facilitates growth for cancer cells that overexpress the receptor. Monoclonal anti-EGFR antibody Cetuximab (CTX) provides significant clinical benefit in patie
Externí odkaz:
https://doaj.org/article/20ddfc5b974349a48705b8719e140d9b
Autor:
William J Placzek, Hiroyuki Yanagawa, Yuko Makita, Matthew B Renfrow, Bruce A Julian, Dana V Rizk, Yusuke Suzuki, Jan Novak, Hitoshi Suzuki
Publikováno v:
PLoS ONE, Vol 13, Iss 1, p e0190967 (2018)
IgA nephropathy is an autoimmune disease characterized by IgA1-containing glomerular immune deposits. We previously proposed a multi-hit pathogenesis model in which patients with IgA nephropathy have elevated levels of circulatory IgA1 with some O-gl
Externí odkaz:
https://doaj.org/article/329c2cc8b46e47aaba9ff7597079f36d
Autor:
Jun eWei, John L Stebbins, Shinichi eKitada, Rupesh eDash, Dayong eZhai, William J Placzek, Bainan eWu, Michele F Rega, Ziming eZhang, Elisa eBarile, Li eYang, Russell eDahl, Paul B. Fisher, John C Reed, Maurizio ePellecchia
Publikováno v:
Frontiers in Oncology, Vol 1 (2011)
Our focus in the past several years has been on the identification of novel and effective pan-Bcl-2 antagonists. We have recently reported a series of Apogossypolone (ApoG2) derivatives, resulting in the chiral compound (+/-) BI97D6. We report here t
Externí odkaz:
https://doaj.org/article/9da35fc70df844858b05d2972780c82d
Publikováno v:
Journal of Biological Chemistry. :104778
Autor:
Anirban Kundu, Garrett J. Brinkley, Hyeyoung Nam, Suman Karki, Richard Kirkman, Hayley Widden, Michelle Johnson, Juan Liu, Yasaman Heidarian, Nader Mahmoudzadeh, Devin Absher, Han-Fei Ding, David Crosman, William J. Placzek, Jason Locasale, Dinesh Rakheja, Victor Darley-Usmar, Jason Tennessen, Sunil Sudarshan
Publikováno v:
Cancer Research. 83:3705-3705
The oncometabolite, L-2-hydroxyglutarate (L-2HG) is elevated in the most common form of renal cell carcinoma-RCC (clear cell histology) and promotes tumor progression. L-2HG is structurally similar to α-ketoglutarate (α-KG). Therefore, L-2HG can co
Autor:
Zeel Patel, Hayley Widden, Hasan Alrefai, Anita B. Hjelmeland, Patricia H. Hicks, Jason M. Warram, Rune T. Pedersen, G. Yancey Gillespie, Christopher D. Willey, William J. Placzek, Nicholas Eustace, Joshua C. Anderson
Publikováno v:
Oncogene
Glioblastoma (GBM) is an aggressive malignancy with limited effectiveness of standard of care therapies including surgery, radiation, and temozolomide chemotherapy necessitating novel therapeutics. Unfortunately, GBMs also harbor several signaling al
Autor:
William J. Placzek, Hayley Widden
Publikováno v:
Communications Biology
Communications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
Communications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
MCL1 (myeloid cell leukemia-1) is a widely recognized pro-survival member of the Bcl-2 (B-cell lymphoma protein 2) family and a promising target for cancer therapy. While the role MCL1 plays in apoptosis is well defined, its participation in emerging
Autor:
Robert Bostwick, Corinne Augello-Szafran, William J. Placzek, Hayley Widden, Anish Vadukoot, Rebecca J. Boohaker, Mark J. Suto, Omar Moukha-Chafiq, Robert H. Whitaker
Publikováno v:
The FASEB Journal. 35
Autor:
Tyler J. Stewart, Milan Raska, Robert H. Whitaker, Kazuo Takahashi, Matthew B. Renfrow, William J. Placzek, Jan Novak
Publikováno v:
Glycobiology
GalNAc-type O-glycans are often added to proteins post-translationally in a clustered manner in repeat regions of proteins, such as mucins and IgA1. Observed IgA1 glycosylation patterns show that glycans occur at similar sites with similar structures