Zobrazeno 1 - 10
of 76
pro vyhledávání: '"William J Placzek"'
Autor:
Anna McGriff, William J Placzek
Publikováno v:
PLoS ONE, Vol 18, Iss 1, p e0277726 (2023)
B-cell lymphoma 2 (Bcl-2) proteins are central, conserved regulators of apoptosis. Bcl-2 family function is regulated by binding interactions between the Bcl-2 homology 3 (BH3) motif in pro-apoptotic family members and the BH3 binding groove found in
Externí odkaz:
https://doaj.org/article/4f9e9b8783324ff5adc457d09f835e8a
Autor:
Hayley Widden, William J. Placzek
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
In this review Widden and Placzek synthesize studies characterizing the influence that myeloid cell leukemia-1 (MCL1) has on cell proliferation, DNA damage response, autophagy, calcium handling, and mitochondrial quality control to highlight the broa
Externí odkaz:
https://doaj.org/article/3e4c89c0ce7e405aa2ea6b1f132107cc
Autor:
Christine Carico, William J. Placzek
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 13, p 11218 (2023)
Polypyrimidine tract binding protein 1 (PTBP1) is one of the most well-described RNA binding proteins, known initially for its role as a splicing repressor before later studies revealed its numerous roles in RNA maturation, stability, and translation
Externí odkaz:
https://doaj.org/article/0572d3d06e544c6c9ee498232da88cfc
Autor:
Sindhu Nair, Hoa Q Trummell, Rajani Rajbhandari, Nanda K Thudi, Susan E Nozell, Jason M Warram, Christopher D Willey, Eddy S Yang, William J Placzek, James A Bonner, Markus Bredel
Publikováno v:
PLoS ONE, Vol 15, Iss 2, p e0229077 (2020)
Epidermal growth factor receptor (EGFR) is a pro-tumorigenic receptor tyrosine kinase that facilitates growth for cancer cells that overexpress the receptor. Monoclonal anti-EGFR antibody Cetuximab (CTX) provides significant clinical benefit in patie
Externí odkaz:
https://doaj.org/article/20ddfc5b974349a48705b8719e140d9b
Autor:
Anirban Kundu, Garrett J. Brinkley, Hyeyoung Nam, Suman Karki, Richard Kirkman, Hayley Widden, Michelle Johnson, Juan Liu, Yasaman Heidarian, Nader Mahmoudzadeh, Devin Absher, Han-Fei Ding, David Crosman, William J. Placzek, Jason Locasale, Dinesh Rakheja, Victor Darley-Usmar, Jason Tennessen, Sunil Sudarshan
Publikováno v:
Cancer Research. 83:3705-3705
The oncometabolite, L-2-hydroxyglutarate (L-2HG) is elevated in the most common form of renal cell carcinoma-RCC (clear cell histology) and promotes tumor progression. L-2HG is structurally similar to α-ketoglutarate (α-KG). Therefore, L-2HG can co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::94b6526d5cd6f5e82483bd7747677c28
https://doi.org/10.1158/1538-7445.am2023-3705
https://doi.org/10.1158/1538-7445.am2023-3705
Autor:
William J Placzek, Hiroyuki Yanagawa, Yuko Makita, Matthew B Renfrow, Bruce A Julian, Dana V Rizk, Yusuke Suzuki, Jan Novak, Hitoshi Suzuki
Publikováno v:
PLoS ONE, Vol 13, Iss 1, p e0190967 (2018)
IgA nephropathy is an autoimmune disease characterized by IgA1-containing glomerular immune deposits. We previously proposed a multi-hit pathogenesis model in which patients with IgA nephropathy have elevated levels of circulatory IgA1 with some O-gl
Externí odkaz:
https://doaj.org/article/329c2cc8b46e47aaba9ff7597079f36d
Autor:
Robert H. Whitaker, William J. Placzek
Publikováno v:
Cells, Vol 8, Iss 4, p 346 (2019)
Chemotherapeutic targeting of microtubules has been the standard of care in treating a variety of malignancies for decades. During mitosis, increased microtubule dynamics are necessary for mitotic spindle formation and successful chromosomal segregat
Externí odkaz:
https://doaj.org/article/12cc624f39ac4d918df7e3e2a8c3c476
Publikováno v:
Journal of Biological Chemistry. :104778
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::02b5734478f8975dade1cec62696ccfa
https://doi.org/10.1016/j.jbc.2023.104778
https://doi.org/10.1016/j.jbc.2023.104778
Autor:
Zeel Patel, Hayley Widden, Hasan Alrefai, Anita B. Hjelmeland, Patricia H. Hicks, Jason M. Warram, Rune T. Pedersen, G. Yancey Gillespie, Christopher D. Willey, William J. Placzek, Nicholas Eustace, Joshua C. Anderson
Publikováno v:
Oncogene
Glioblastoma (GBM) is an aggressive malignancy with limited effectiveness of standard of care therapies including surgery, radiation, and temozolomide chemotherapy necessitating novel therapeutics. Unfortunately, GBMs also harbor several signaling al
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a925fdd83a335d73ea893ba178497cf9
https://doi.org/10.1038/s41388-020-01511-9
https://doi.org/10.1038/s41388-020-01511-9
Autor:
Jia Cui, William J. Placzek
Publikováno v:
International Journal of Molecular Sciences, Vol 19, Iss 1, p 308 (2018)
Anti-apoptotic B cell lymphoma 2 (BCL2) family members (BCL2, MCL1, BCLxL, BCLW, and BFL1) are key players in the regulation of intrinsic apoptosis. Dysregulation of these proteins not only impairs normal development, but also contributes to tumor pr
Externí odkaz:
https://doaj.org/article/702be8e6de06404f8baf088bc3a9a014