Zobrazeno 1 - 10
of 585
pro vyhledávání: '"William J Jusko"'
Publikováno v:
PLoS ONE, Vol 13, Iss 5, p e0197258 (2018)
Circadian information is maintained in mammalian tissues by a cell-autonomous network of transcriptional feedback loops that have evolved to optimally regulate tissue-specific functions. An analysis of daily gene expression in different tissues, as w
Externí odkaz:
https://doaj.org/article/fc4493b634cc4775ad87e3f3782d68e7
Publikováno v:
PLoS ONE, Vol 13, Iss 6, p e0197534 (2018)
Circadian clocks, present in almost all cells of the body, are entrained to rhythmic changes in the environment (e.g. light/dark cycles). Genes responsible for this timekeeping are named core-clock genes, which through transcriptional feedback intera
Externí odkaz:
https://doaj.org/article/a040e04d72204dd8a0370216abd484e2
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e81679 (2013)
A retrospective meta-modeling analysis was performed to integrate previously reported data of glucocorticoid (GC) effects on glucose regulation following a single intramuscular dose (50 mg/kg), single intravenous doses (10, 50 mg/kg), and intravenous
Externí odkaz:
https://doaj.org/article/7aaf522b37ae4745989d4320ce1210be
Publikováno v:
PLoS ONE, Vol 6, Iss 2, p e17386 (2011)
Type 2 diabetes (T2DM) is a heterogeneous group of diseases that is progressive and involves multiple tissues. Goto-Kakizaki (GK) rats are a polygenic model with elevated blood glucose, peripheral insulin resistance, a non-obese phenotype, and exhibi
Externí odkaz:
https://doaj.org/article/503c5b0df78844aca2b2aacb33979846
Autor:
Artur Świerczek, William J. Jusko
Publikováno v:
Clinical and Translational Science, Vol 16, Iss 9, Pp 1667-1679 (2023)
Abstract Dexamethasone (DEX) given at a dose of 6 mg once‐daily for 10 days is a recommended dosing regimen in patients with coronavirus disease 2019 (COVID‐19) requiring oxygen therapy. We developed a population pharmacokinetic and pharmacodynam
Externí odkaz:
https://doaj.org/article/57011fa882704e808777f2b7866cdef9
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 12, Iss 5, Pp 668-680 (2023)
Abstract Minimal physiologically‐based pharmacokinetic (mPBPK) models are an alternative to full physiologically‐based pharmacokinetic (PBPK) models as they offer reduced complexity while maintaining the physiological interpretation of key model
Externí odkaz:
https://doaj.org/article/871f037cddd54704a727c73c1da9c236
Autor:
Xiaonan Li, William J. Jusko
Publikováno v:
Drug Metabolism and Disposition. 50:1501-1512
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::44afe79c7fc12d0f13d9e25e4c145621
https://doi.org/10.1124/dmd.122.000994
https://doi.org/10.1124/dmd.122.000994
Autor:
Yoo-Seong Jeong, William J Jusko
Publikováno v:
Pharmaceutical Research. 39:463-479
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b0fcef1b261cd030e58bdaeac1d8431d
https://doi.org/10.1007/s11095-022-03211-3
https://doi.org/10.1007/s11095-022-03211-3
Autor:
Xi Chen, Dipti Pawaskar, Fiona Glassman, Mark Biondo, Frauke May, Anthony Roberts, Andrew McKenzie, Michael A. Tortorici, Marc W. Nolte, William J. Jusko
Publikováno v:
Clinical and Translational Science. 15:709-720
Factor XII (FXII) is a serine protease involved in multiple cascades, including the kallikrein-kinin system. It may play a role in diseases in which the downstream cascades are dysregulated, such as hereditary angioedema. Garadacimab (CSL312) is a fi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c60ab1e3fef2cc740cfc6c314ad35ec
https://doi.org/10.1111/cts.13192
https://doi.org/10.1111/cts.13192
Autor:
Yoo-Seong Jeong, William J. Jusko
Publikováno v:
The AAPS Journal. 25
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2069f427259401cba84a95d5996a938d
https://doi.org/10.1208/s12248-022-00779-x
https://doi.org/10.1208/s12248-022-00779-x