Zobrazeno 1 - 10
of 48
pro vyhledávání: '"William J Godinez"'
Autor:
Barbara Di Ventura, Benoît Knecht, Helena Andreas, William J Godinez, Miriam Fritsche, Karl Rohr, Walter Nickel, Dieter W Heermann, Victor Sourjik
Publikováno v:
Molecular Systems Biology, Vol 9, Iss 1, Pp 1-12 (2013)
Abstract The mechanisms underlying chromosome segregation in prokaryotes remain a subject of debate and no unifying view has yet emerged. Given that the initial disentanglement of duplicated chromosomes could be achieved by purely entropic forces, ev
Externí odkaz:
https://doaj.org/article/ba0759c53c7c4953a054b5ae1e63b6ee
Autor:
Sergey Ivanchenko, William J Godinez, Marko Lampe, Hans-Georg Kräusslich, Roland Eils, Karl Rohr, Christoph Bräuchle, Barbara Müller, Don C Lamb
Publikováno v:
PLoS Pathogens, Vol 5, Iss 11, p e1000652 (2009)
Assembly and release of human immunodeficiency virus (HIV) occur at the plasma membrane of infected cells and are driven by the Gag polyprotein. Previous studies analyzed viral morphogenesis using biochemical methods and static images, while dynamic
Externí odkaz:
https://doaj.org/article/3aaeffe7c9b945ddbd33de394217df29
Autor:
Andrea Imle, Peter Kumberger, Nikolas D. Schnellbächer, Jana Fehr, Paola Carrillo-Bustamante, Janez Ales, Philip Schmidt, Christian Ritter, William J. Godinez, Barbara Müller, Karl Rohr, Fred A. Hamprecht, Ulrich S. Schwarz, Frederik Graw, Oliver T. Fackler
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-18 (2019)
Here, using an integrative experimental and computational approach, Imle et al. show how cell motility and density affect HIV cell-associated transmission in a three-dimensional tissue-like culture system of CD4+ T cells and collagen, and how differe
Externí odkaz:
https://doaj.org/article/9b883324a99d4e44ab53be00321fd321
Autor:
Delia Bucher, Felix Frey, Kem A. Sochacki, Susann Kummer, Jan-Philip Bergeest, William J. Godinez, Hans-Georg Kräusslich, Karl Rohr, Justin W. Taraska, Ulrich S. Schwarz, Steeve Boulant
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
The sequence of structural and molecular events during clathrin-mediated endocytosis is unclear. Here the authors combine correlative microscopy and simple mathematical growth laws to demonstrate that the flat patch starts to curve when around 70% of
Externí odkaz:
https://doaj.org/article/3f0780a0131e44ce8d01e1cb3d81a9e5
Autor:
William J. Godinez, Eric J. Ma, Alexander T. Chao, Luying Pei, Peter Skewes-Cox, Stephen M. Canham, Jeremy L. Jenkins, Joseph M. Young, Eric J. Martin, W. Armand Guiguemde
Publikováno v:
Nature Machine Intelligence. 4:180-186
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aca04c8c1e777bae30923672ad727428
https://doi.org/10.1038/s42256-022-00448-w
https://doi.org/10.1038/s42256-022-00448-w
Autor:
Marc A. Coram, Lisha Wang, William J. Godinez, David T. Barkan, Zan Armstrong, D. Michael Ando, Brian Y. Feng
Publikováno v:
ACS infectious diseases. 8(1)
Combination therapies are common in many therapeutic contexts, including infectious diseases and cancer. A common approach for evaluating combinations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72298692d3a3ae4352df95e3e2f916fe
https://pubmed.ncbi.nlm.nih.gov/34937332
https://pubmed.ncbi.nlm.nih.gov/34937332
Autor:
Michal Pikusa, Olivier René, Sarah Williams, Yen-Liang Chen, Eric Martin, William J. Godinez, Srinivasa P S Rao, W. Armand Guiguemde, Florian Nigsch
Designing novel molecules with targeted biological activities and optimized physicochemical properties is a challenging endeavor in drug discovery. Recent developments in artificial intelligence have enhanced the early steps of de novo drug design an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e1fae6e9e95846835886d45388f83b83
https://doi.org/10.1101/2021.12.10.472084
https://doi.org/10.1101/2021.12.10.472084
Autor:
Nikolas D Schnellbächer, Philip Schmidt, Fred A. Hamprecht, William J. Godinez, Peter Kumberger, Janez Ales, Ulrich S. Schwarz, Paola Carrillo-Bustamante, Christian Ritter, Barbara Müller, Karl Rohr, Oliver T. Fackler, Andrea Imle, Jana Fehr, Frederick Graw
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-18 (2019)
Nature Communications
Nature Communications
Pathogens face varying microenvironments in vivo, but suitable experimental systems and analysis tools to dissect how three-dimensional (3D) tissue environments impact pathogen spread are lacking. Here we develop an Integrative method to Study Pathog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0ae801a40884ba3bcb21636bd6f4a11
https://doaj.org/article/9b883324a99d4e44ab53be00321fd321
https://doaj.org/article/9b883324a99d4e44ab53be00321fd321
Autor:
Armand Guiguemde, Stephen M. Canham, Peter Skewes-Cox, Eric J. Martin, William J. Godinez, Alex Chao, Eric J. Ma, Luying Pei, Joseph Michael Young, Jeremy L. Jenkins
Recent advances in generative modeling allow designing novel compounds through deep neural networks. One such neural network model, the Junction Tree Variational Auto- Encoder (JT-VAE), excels at proposing chemically valid structures. Based on JT-VAE
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::71b0806cad35ce502c2b34847a7b90a1
https://doi.org/10.33774/chemrxiv-2021-5t5xx
https://doi.org/10.33774/chemrxiv-2021-5t5xx
Autor:
Srijan Ranjitkar, Xian Zhang, Robert Lowell Simmons, William J. Godinez, Imtiaz Hossain, Helen Chan, Brian Y. Feng, Cindy Li, Dita M. Rasper
Publikováno v:
ACS chemical biology. 14(6)
Beta-lactams comprise one of the earliest classes of antibiotic therapies. These molecules covalently inhibit enzymes from the family of penicillin-binding proteins (PBPs), which are essential in construction of the bacterial cell wall. As a result,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c3bfd296fbab3695c1d8a28183e3fc9
https://pubmed.ncbi.nlm.nih.gov/31184469
https://pubmed.ncbi.nlm.nih.gov/31184469