Zobrazeno 1 - 10
of 28
pro vyhledávání: '"William J Brook"'
Publikováno v:
PLoS ONE, Vol 7, Iss 10, p e48176 (2012)
We employed in vitro site selection to identify a consensus binding sequence for the Drosophila melanogaster Tbx20 T-box transcription factor homolog Midline. We purified a bacterially expressed T-box DNA binding domain of Midline, and used it in fou
Externí odkaz:
https://doaj.org/article/f56b19df80d443b2af2bc50a88cee746
Autor:
Lindsay A. Phillips, Markle L. Atienza, Jae-Ryeon Ryu, Pia C. Svendsen, Lynn K. Kelemen, William J. Brook
Publikováno v:
Biology Open, Vol 11, Iss 5 (2022)
Ventral leg patterning in Drosophila is controlled by the expression of the redundant T-box Transcription factors midline (mid) and H15. Here, we show that mid represses the Dpp-activated gene Daughters against decapentaplegic (Dad) through a consens
Externí odkaz:
https://doaj.org/article/881eaf85b8f143d1a55e3a870431fe35
Publikováno v:
Biology Open, Vol 4, Iss 12, Pp 1707-1714 (2015)
The Drosophila Tbx20 homologs midline and H15 act as selector genes for ventral fate in Drosophila legs. midline and H15 expression defines the ventral domain of the leg and the two genes are necessary and sufficient for the development of ventral fa
Externí odkaz:
https://doaj.org/article/3989c1a57bfb4ca98e7b2b6a4e3c9b90
Autor:
Lindsay A. Phillips, Markle L. Atienza, Jae-Ryeon Ryu, Pia C. Svendsen, Lynn K. Kelemen, William J. Brook
Publikováno v:
Biology open. 11(5)
Ventral leg patterning in Drosophila is controlled by the expression of the redundant T-box Transcription factors midline (mid) and H15. Here we show that mid represses the Dpp-activated gene Daughters against decapentaplegic (Dad) through a consensu
Publikováno v:
Biology Open
Biology Open, Vol 4, Iss 12, Pp 1707-1714 (2015)
Biology Open, Vol 4, Iss 12, Pp 1707-1714 (2015)
The Drosophila Tbx20 homologs midline and H15 act as selector genes for ventral fate in Drosophila legs. midline and H15 expression defines the ventral domain of the leg and the two genes are necessary and sufficient for the development of ventral fa
Autor:
Lindsay A. Phillips, Pia C. Svendsen, Ashish R. Deshwar, Nima Najand, Jae-Ryeon Ryu, William J. Brook
Publikováno v:
Developmental biology. 455(1)
mid and H15 encode Tbx20 transcription factors that specify ventral pattern in the Drosophila leg. We find that there are at least two pathways for mid and H15 specification of ventral fate. In the first pathway, mid and H15 negatively regulate Dpp,
Autor:
William J. Brook
Publikováno v:
Fly. 4:159-162
A key event in fly limb development is the binary subdivision of the cardinal axes of imaginal discs by selector genes.(1-3) As an example, all limbs are partitioned into anterior and posterior compartments through the expression of engrailed (en) in
Publikováno v:
Development. 136:2689-2693
Regional fates in the developing limbs of Drosophila melanogasterare controlled by selector gene transcription factors. Ventral fate in the fly leg is specified by the expression of the ligand Wingless. We present evidence that midline and H15, membe
Publikováno v:
Developmental Biology. 292(2):418-429
The Drosophila melanogaster ventral nerve cord derives from neural progenitor cells called neuroblasts. Individual neuroblasts have unique gene expression profiles and give rise to distinct clones of neurons and glia. The specification of neuroblast
Autor:
William J. Brook, Pia C. Svendsen, Marita Buescher, Murni Tio, William Chia, Cindy M. Miskolczi-McCallum, Guy Tear
Publikováno v:
Current Biology. 14:1694-1702
Background: Segmentation of the Drosophila embryo is a classic paradigm for pattern formation during development. The Wnt-1 homolog Wingless (Wg) is a key player in the establishment of a segmentally reiterated pattern of cell type specification. The