Zobrazeno 1 - 10
of 31
pro vyhledávání: '"William J Bosche"'
Autor:
Benjamin Varco-Merth, Morgan Chaunzwa, Derick M Duell, Alejandra Marenco, William Goodwin, Rachel Dannay, Michael Nekorchuk, Danica Shao, Kathleen Busman-Sahay, Christine M Fennessey, Lorna Silipino, Michael Hull, William J Bosche, Randy Fast, Kelli Oswald, Rebecca Shoemaker, Rachele Bochart, Rhonda MacAllister, Caralyn S Labriola, Jeremy V Smedley, Michael K Axthelm, Miles P Davenport, Paul T Edlefsen, Jacob D Estes, Brandon F Keele, Jeffrey D Lifson, Sharon R Lewin, Louis J Picker, Afam A Okoye
Publikováno v:
PLoS Pathogens, Vol 20, Iss 8, p e1012496 (2024)
Persistence of the rebound-competent viral reservoir (RCVR) within the CD4+ T cell compartment of people living with HIV remains a major barrier to HIV cure. Here, we determined the effects of the pan-lymphocyte-depleting monoclonal antibody (mAb) al
Externí odkaz:
https://doaj.org/article/98aa0bf5a0db40c1870449c56d1dca1f
Autor:
Brandon F Keele, Afam A Okoye, Christine M Fennessey, Benjamin Varco-Merth, Taina T Immonen, Emek Kose, Andrew Conchas, Mykola Pinkevych, Leslie Lipkey, Laura Newman, Agatha Macairan, Marjorie Bosche, William J Bosche, Brian Berkemeier, Randy Fast, Mike Hull, Kelli Oswald, Rebecca Shoemaker, Lorna Silipino, Robert J Gorelick, Derick Duell, Alejandra Marenco, William Brantley, Jeremy Smedley, Michael Axthelm, Miles P Davenport, Jeffrey D Lifson, Louis J Picker
Publikováno v:
PLoS Pathogens, Vol 20, Iss 4, p e1012135 (2024)
The rebound competent viral reservoir (RCVR)-virus that persists during antiretroviral treatment (ART) and can reignite systemic infection when treatment is stopped-is the primary barrier to eradicating HIV. We used time to initiation of ART during p
Externí odkaz:
https://doaj.org/article/65fa1fcf2796486fb2e2ddf45842dec6
Autor:
Fredrik Barrenäs, Scott G Hansen, Lynn Law, Connor Driscoll, Richard R Green, Elise Smith, Jean Chang, Inah Golez, Taryn Urion, Xinxia Peng, Leanne Whitmore, Daniel Newhouse, Colette M Hughes, David Morrow, Kurt T Randall, Andrea N Selseth, Julia C Ford, Roxanne M Gilbride, Bryan E Randall, Emily Ainslie, Kelli Oswald, Rebecca Shoemaker, Randy Fast, William J Bosche, Michael K Axthelm, Yoshinori Fukazawa, George N Pavlakis, Barbara K Felber, Slim Fourati, Rafick-Pierre Sekaly, Jeffrey D Lifson, Jan Komorowski, Ewelina Kosmider, Danica Shao, Wenjun Song, Paul T Edlefsen, Louis J Picker, Michael Gale
Publikováno v:
PLoS Pathogens, Vol 17, Iss 7, p e1009278 (2021)
Simian immunodeficiency virus (SIV) challenge of rhesus macaques (RMs) vaccinated with strain 68-1 Rhesus Cytomegalovirus (RhCMV) vectors expressing SIV proteins (RhCMV/SIV) results in a binary outcome: stringent control and subsequent clearance of h
Externí odkaz:
https://doaj.org/article/cd57c9263ff449bb8bd672c756c1208a
Autor:
Bridget S Fisher, Richard R Green, Rachel R Brown, Matthew P Wood, Tiffany Hensley-McBain, Cole Fisher, Jean Chang, Andrew D Miller, William J Bosche, Jeffrey D Lifson, Maud Mavigner, Charlene J Miller, Michael Gale, Guido Silvestri, Ann Chahroudi, Nichole R Klatt, Donald L Sodora
Publikováno v:
PLoS Pathogens, Vol 14, Iss 2, p e1006871 (2018)
Liver disease is a leading contributor to morbidity and mortality during HIV infection, despite the use of combination antiretroviral therapy (cART). The precise mechanisms of liver disease during HIV infection are poorly understood partially due to
Externí odkaz:
https://doaj.org/article/d953b7a3ce3c4ce5924eb5d89c356efe
Autor:
Christine M Fennessey, Mykola Pinkevych, Taina T Immonen, Arnold Reynaldi, Vanessa Venturi, Priyanka Nadella, Carolyn Reid, Laura Newman, Leslie Lipkey, Kelli Oswald, William J Bosche, Matthew T Trivett, Claes Ohlen, David E Ott, Jacob D Estes, Gregory Q Del Prete, Jeffrey D Lifson, Miles P Davenport, Brandon F Keele
Publikováno v:
PLoS Pathogens, Vol 13, Iss 5, p e1006359 (2017)
HIV and SIV infection dynamics are commonly investigated by measuring plasma viral loads. However, this total viral load value represents the sum of many individual infection events, which are difficult to independently track using conventional seque
Externí odkaz:
https://doaj.org/article/12624c7f2b5640c181fb68da867a31e1
Autor:
Scott G. Hansen, Meaghan H. Hancock, Daniel Malouli, Emily E. Marshall, Colette M. Hughes, Kurt T. Randall, David Morrow, Julia C. Ford, Roxanne M. Gilbride, Andrea N. Selseth, Renee Espinosa Trethewy, Lindsey M. Bishop, Kelli Oswald, Rebecca Shoemaker, Brian Berkemeier, William J. Bosche, Michael Hull, Lorna Silipino, Michael Nekorchuk, Kathleen Busman-Sahay, Jacob D. Estes, Michael K. Axthelm, Jeremy Smedley, Danica Shao, Paul T. Edlefsen, Jeffrey D. Lifson, Klaus Früh, Jay A. Nelson, Louis J. Picker
Publikováno v:
Sci Immunol
The strain 68-1 rhesus cytomegalovirus (RhCMV)–based vaccine for simian immunodeficiency virus (SIV) can stringently protect rhesus macaques (RMs) from SIV challenge by arresting viral replication early in primary infection. This vaccine elicits un
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0029e764e7ae4b9f7d96198478afd222
https://europepmc.org/articles/PMC9387538/
https://europepmc.org/articles/PMC9387538/
Autor:
Taryn Urion, Connor B. Driscoll, Rebecca Shoemaker, Emily Ainslie, Rafick Pierre Sekaly, Slim Fourati, Yoshinori Fukazawa, Lynn Law, Richard Green, Fredrik Barrenäs, Ewelina Kosmider, Randy Fast, David Morrow, Paul T. Edlefsen, Kurt T. Randall, Michael K. Axthelm, Andrea N. Selseth, William J. Bosche, Julia C. Ford, Jeffrey D. Lifson, Jan Komorowski, Barbara K. Felber, Jean Chang, Elise Smith, Leanne S. Whitmore, Bryan E. Randall, Danica Shao, Kelli Oswald, Michael Gale, Colette M. Hughes, Inah Golez, George N. Pavlakis, Scott G. Hansen, Daniel J. Newhouse, Xinxia Peng, Louis J. Picker, Wenjun Song, Roxanne M. Gilbride
Publikováno v:
PLoS Pathogens, Vol 17, Iss 7, p e1009278 (2021)
PLoS Pathogens
PLoS Pathogens
Simian immunodeficiency virus (SIV) challenge of rhesus macaques (RMs) vaccinated with strain 68–1 Rhesus Cytomegalovirus (RhCMV) vectors expressing SIV proteins (RhCMV/SIV) results in a binary outcome: stringent control and subsequent clearance of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37ca25eff1157bed4deb2d984495f92d
https://doaj.org/article/cd57c9263ff449bb8bd672c756c1208a
https://doaj.org/article/cd57c9263ff449bb8bd672c756c1208a
Autor:
Richard Green, Julia C. Ford, Jeffrey D. Lifson, David Morrow, Emily Ainslie, Rafick-Pierre Sekaly, Kurt T. Randall, William J. Bosche, Barbara K. Felber, Michael K. Axthelm, Colette M. Hughes, Louis J. Picker, Daniel J. Newhouse, Paul T. Edlefsen, Jason Shao, Scott G. Hansen, Yoshinori Fukazawa, Wenjun Song, Roxanne M. Gilbride, Andrea N. Selseth, Kelli Oswald, Jan Komorowski, Fredrik Barrenäs, Xinxia Peng, Connor B. Driscoll, George N. Pavlakis, Leanne S. Whitmore, Rebecca Shoemaker, Inah Golez, Taryn Urion, Slim Fourati, Bryan E. Randall, Lynn Law, Elise Smith, Michael Gale, Ewelina Kosmider, Randy Fast, Jean Chang
Simian immunodeficiency virus (SIV) challenge of rhesus macaques (RMs) vaccinated with Rhesus Cytomegalovirus (RhCMV) vectors expressing SIV proteins (RhCMV/SIV) results in a binary outcome: stringent control and subsequent clearance of highly pathog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::75e7442361986b0d9e8e5f5642b19b84
https://doi.org/10.1101/2021.01.11.426199
https://doi.org/10.1101/2021.01.11.426199
Autor:
Michael K. Axthelm, Klaus Früh, Julia C. Ford, Jeffrey D. Lifson, Ravi Iyer, Louis J. Picker, William J. Bosche, Nessy John, Roxanne M. Gilbride, Daniel Malouli, Shaheed Abdulhaqq, Brian Berkemeier, Abigail B. Ventura, Jennie Womack, David Morrow, Kelli Oswald, Isabel Scholz, Jonah B. Sacha, Jason Shao, Scott G. Hansen, Michael Hull, Andrea N. Selseth, Paul T. Edlefsen, Colette M. Hughes, Rebecca Shoemaker, Marieke C. Verweij
Publikováno v:
Science
Strain 68-1 rhesus cytomegalovirus (RhCMV) vectors expressing simian immunodeficiency virus (SIV) antigens elicit CD8+ T cells that recognize peptide epitopes presented by major histocompatibility complex (MHC)-II and MHC-E molecules, instead of MHC-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5a670a6b344703a0c7f467acda178d8
https://doi.org/10.1101/2020.09.30.321158
https://doi.org/10.1101/2020.09.30.321158
Autor:
Justin M. Greene, Renee G. Espinosa Trethewy, Abigail B. Ventura, Husam Taher, Brian Berkemeier, Luke S. Uebelhoer, Jay A. Nelson, Finn Grey, Colette M. Hughes, Rebecca Shoemaker, Daniel Malouli, Courtney R. Papen, William J. Bosche, Louis J. Picker, David Morrow, Meaghan H. Hancock, Roxanne M. Gilbride, Michael Hull, Michael K. Axthelm, Julia C. Ford, Paul T. Edlefsen, Jonah B. Sacha, Daniel N. Streblow, Kurt T. Randall, Jason Shao, Scott G. Hansen, Jeffrey D. Lifson, Kelli Oswald, Matthew R. McArdle, Klaus Früh
Publikováno v:
Malouli, D, Hansen, S G, Hancock, M H, Hughes, C M, Ford, J C, Gilbride, R M, Ventura, A B, Morrow, D, Randall, K T, Taher, H, Uebelhoer, L S, McArdle, M R, Papen, C R, Espinosa Trethewy, R, Oswald, K, Shoemaker, R, Berkemeier, B, Bosche, W J, Hull, M, Greene, J M, Axthelm, M K, Shao, J, Edlefsen, P T, Grey, F, Nelson, J A, Lifson, J D, Streblow, D, Sacha, J B, Früh, K & Picker, L J 2021, ' Cytomegaloviral determinants of CD8+ T cell programming and RhCMV/SIV vaccine efficacy ', Science Immunology, vol. 6, no. 57, eabg5413 . https://doi.org/10.1126/sciimmunol.abg5413
Simian immunodeficiency virus (SIV) insert-expressing, 68-1 Rhesus Cytomegalovirus (RhCMV/SIV) vectors elicit major histocompatibility complex (MHC)-E- and -II-restricted, SIV-specific CD8+ T cell responses, but the basis of these unconventional resp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6054cac299f3617d6d4f213b423984f
https://doi.org/10.1101/2020.09.30.321349
https://doi.org/10.1101/2020.09.30.321349