Zobrazeno 1 - 10
of 42
pro vyhledávání: '"William J Belden"'
Autor:
Jinhee Park, Qiaoqiao Zhu, Emily Mirek, Li Na, Hamidah Raduwan, Tracy G Anthony, William J Belden
Publikováno v:
PLoS ONE, Vol 14, Iss 10, p e0223803 (2019)
The circadian clock and aging are intertwined. Disruption to the normal diurnal rhythm accelerates aging and corresponds with telomere shortening. Telomere attrition also correlates with increase cellular senescence and incidence of chronic disease.
Externí odkaz:
https://doaj.org/article/d040fea317564bf9a67df07bf17c18a3
Publikováno v:
PLoS Genetics, Vol 7, Iss 7, p e1002166 (2011)
Circadian-regulated gene expression is predominantly controlled by a transcriptional negative feedback loop, and it is evident that chromatin modifications and chromatin remodeling are integral to this process in eukaryotes. We previously determined
Externí odkaz:
https://doaj.org/article/c72808c9889044ef9bf3db400f782da5
Autor:
Qiaoqiao Zhu, William J. Belden
Publikováno v:
Journal of Molecular Biology. 432:3466-3482
Circadian rhythms are generated by transcriptional negative feedback loops and require histone modifications and chromatin remodeling to ensure appropriate timing and amplitude of clock gene expression. Circadian modifications to histones are importa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d7b4decfaa1d729bb550416c097e965
https://doi.org/10.1016/j.jmb.2020.01.009
https://doi.org/10.1016/j.jmb.2020.01.009
Autor:
William J. Belden, Jinhee Park
Publikováno v:
BMC Genomics, Vol 19, Iss 1, Pp 1-14 (2018)
BMC Genomics
BMC Genomics
Background Disrupted diurnal rhythms cause accelerated aging and an increased incidence in age-related disease and morbidity. The circadian clock governs cell physiology and metabolism by controlling transcription and chromatin. The goal of this stud
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b3ac4bc6bb9f04ded7e05950f871ed8
http://link.springer.com/article/10.1186/s12864-018-5170-3
http://link.springer.com/article/10.1186/s12864-018-5170-3
Autor:
Yongping Wang, Emily T. Mirek, Tracy G. Anthony, Jinhee Park, Inna A. Nikonorova, William J. Belden, Rana J. T. Al-Baghdadi, Ronald C. Wek
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Scientific Reports
Scientific Reports
The anti-leukemic agent asparaginase activates the integrated stress response (ISR) kinase GCN2 and inhibits signaling via mechanistic target of rapamycin complex 1 (mTORC1). The study objective was to investigate the protective role of activating tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef497c1de47b08be2e4f1ea7b1060471
https://doaj.org/article/8c386a86451643b7ab9901fa57812237
https://doaj.org/article/8c386a86451643b7ab9901fa57812237
Autor:
William J. Belden, Emily T. Mirek, Qiaoqiao Zhu, Tracy G. Anthony, Li Na, Hamidah Raduwan, Jinhee Park
Publikováno v:
PLoS ONE
PLoS ONE, Vol 14, Iss 10, p e0223803 (2019)
PLoS ONE, Vol 14, Iss 10, p e0223803 (2019)
The circadian clock and aging are intertwined. Disruption to the normal diurnal rhythm accelerates aging and corresponds with telomere shortening. Telomere attrition also correlates with increase cellular senescence and incidence of chronic disease.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::941cb427f26b8c89ed14a70744f560c3
http://europepmc.org/articles/PMC6802832
http://europepmc.org/articles/PMC6802832
Publikováno v:
BMC Genomics
BMC Genomics, Vol 20, Iss 1, Pp 1-19 (2019)
BMC Genomics, Vol 20, Iss 1, Pp 1-19 (2019)
Background Histone H3 lysine 4 tri-methylation (H3K4me3) and histone H3 lysine 9 tri-methylation (H3K9me3) are widely perceived to be opposing and often mutually exclusive chromatin modifications. However, both are needed for certain light-activated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::341be484e788680b2b453264f50c9a3a
https://doi.org/10.1186/s12864-019-5729-7
https://doi.org/10.1186/s12864-019-5729-7
Publikováno v:
Nutrients
Volume 11
Issue 3
Nutrients, Vol 11, Iss 3, p 508 (2019)
Volume 11
Issue 3
Nutrients, Vol 11, Iss 3, p 508 (2019)
Poor diet quality has been associated with several age-related chronic conditions, but its relationship to telomere length, a biological marker of cellular aging, is unclear. The purpose of this cross-sectional study was to determine whether overall
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc44723dca7c7e85248874c8464258f7
Publikováno v:
Proceedings of the National Academy of Sciences. 112:4357-4362
The circadian clock is controlled by a network of interconnected feedback loops that require histone modifications and chromatin remodeling. Long noncoding natural antisense transcripts (NATs) originate from Period in mammals and frequency (frq) in N
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::052f93bd37062ce1ba29130aa39fae51
https://doi.org/10.1073/pnas.1406130112
https://doi.org/10.1073/pnas.1406130112