Zobrazeno 1 - 10
of 58
pro vyhledávání: '"William J Belden"'
Publikováno v:
BMC Genomics, Vol 20, Iss 1, Pp 1-19 (2019)
Abstract Background Histone H3 lysine 4 tri-methylation (H3K4me3) and histone H3 lysine 9 tri-methylation (H3K9me3) are widely perceived to be opposing and often mutually exclusive chromatin modifications. However, both are needed for certain light-a
Externí odkaz:
https://doaj.org/article/d901e537ea2d4b7da54ce87428a264d8
Autor:
Jinhee Park, William J. Belden
Publikováno v:
BMC Genomics, Vol 19, Iss 1, Pp 1-14 (2018)
Abstract Background Disrupted diurnal rhythms cause accelerated aging and an increased incidence in age-related disease and morbidity. The circadian clock governs cell physiology and metabolism by controlling transcription and chromatin. The goal of
Externí odkaz:
https://doaj.org/article/67e531e130b04259b7b89d81ac413959
Autor:
Rana J. T. Al-Baghdadi, Inna A. Nikonorova, Emily T. Mirek, Yongping Wang, Jinhee Park, William J. Belden, Ronald C. Wek, Tracy G. Anthony
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Abstract The anti-leukemic agent asparaginase activates the integrated stress response (ISR) kinase GCN2 and inhibits signaling via mechanistic target of rapamycin complex 1 (mTORC1). The study objective was to investigate the protective role of acti
Externí odkaz:
https://doaj.org/article/8c386a86451643b7ab9901fa57812237
Autor:
Jinhee Park, Qiaoqiao Zhu, Emily Mirek, Li Na, Hamidah Raduwan, Tracy G Anthony, William J Belden
Publikováno v:
PLoS ONE, Vol 14, Iss 10, p e0223803 (2019)
The circadian clock and aging are intertwined. Disruption to the normal diurnal rhythm accelerates aging and corresponds with telomere shortening. Telomere attrition also correlates with increase cellular senescence and incidence of chronic disease.
Externí odkaz:
https://doaj.org/article/d040fea317564bf9a67df07bf17c18a3
Publikováno v:
Biology, Vol 3, Iss 3, Pp 560-577 (2014)
Since the cloning and discovery of DNA methyltransferases (DNMT), there has been a growing interest in DNA methylation, its role as an epigenetic modification, how it is established and removed, along with the implications in development and disease.
Externí odkaz:
https://doaj.org/article/1442fad61d724b89b75c3653790efaeb
Autor:
Qiaoqiao Zhu, William J. Belden
Publikováno v:
Journal of Molecular Biology. 432:3466-3482
Circadian rhythms are generated by transcriptional negative feedback loops and require histone modifications and chromatin remodeling to ensure appropriate timing and amplitude of clock gene expression. Circadian modifications to histones are importa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d7b4decfaa1d729bb550416c097e965
https://doi.org/10.1016/j.jmb.2020.01.009
https://doi.org/10.1016/j.jmb.2020.01.009
Autor:
William J. Belden, Jinhee Park
Publikováno v:
BMC Genomics, Vol 19, Iss 1, Pp 1-14 (2018)
BMC Genomics
BMC Genomics
Background Disrupted diurnal rhythms cause accelerated aging and an increased incidence in age-related disease and morbidity. The circadian clock governs cell physiology and metabolism by controlling transcription and chromatin. The goal of this stud
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b3ac4bc6bb9f04ded7e05950f871ed8
http://link.springer.com/article/10.1186/s12864-018-5170-3
http://link.springer.com/article/10.1186/s12864-018-5170-3
Publikováno v:
PLoS Genetics, Vol 7, Iss 7, p e1002166 (2011)
Circadian-regulated gene expression is predominantly controlled by a transcriptional negative feedback loop, and it is evident that chromatin modifications and chromatin remodeling are integral to this process in eukaryotes. We previously determined
Externí odkaz:
https://doaj.org/article/c72808c9889044ef9bf3db400f782da5
Autor:
Yongping Wang, Emily T. Mirek, Tracy G. Anthony, Jinhee Park, Inna A. Nikonorova, William J. Belden, Rana J. T. Al-Baghdadi, Ronald C. Wek
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Scientific Reports
Scientific Reports
The anti-leukemic agent asparaginase activates the integrated stress response (ISR) kinase GCN2 and inhibits signaling via mechanistic target of rapamycin complex 1 (mTORC1). The study objective was to investigate the protective role of activating tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef497c1de47b08be2e4f1ea7b1060471
https://doaj.org/article/8c386a86451643b7ab9901fa57812237
https://doaj.org/article/8c386a86451643b7ab9901fa57812237