Zobrazeno 1 - 10
of 374
pro vyhledávání: '"William J, Sullivan"'
Autor:
Fengrong Wang, Michael J. Holmes, Hea Jin Hong, Pariyamon Thaprawat, Geetha Kannan, My-Hang Huynh, Tracey L. Schultz, M. Haley Licon, Sebastian Lourido, Wenzhao Dong, Jailson Brito Querido, William J. Sullivan, Seán E. O’Leary, Vern B. Carruthers
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract The parasite Toxoplasma gondii persists in its hosts by converting from replicating tachyzoites to latent bradyzoites housed in tissue cysts. The molecular mechanisms that mediate T. gondii differentiation remain poorly understood. Through a
Externí odkaz:
https://doaj.org/article/344823925b104d6a82ccf0c94f14d18f
Autor:
Michael J. Holmes, Matheus S. Bastos, Vishakha Dey, Vanessa Severo, Ronald C. Wek, William J. Sullivan
Publikováno v:
mBio, Vol 15, Iss 6 (2024)
ABSTRACT The protozoan parasite Toxoplasma gondii causes serious opportunistic disease due to its ability to persist in patients as latent tissue cysts. The molecular mechanisms coordinating conversion between proliferative parasites (tachyzoites) an
Externí odkaz:
https://doaj.org/article/a8cceeb976764713b579ecae1aea342e
Autor:
Constanza Cristaldi, Ana M. Saldarriaga Cartagena, Agustina Ganuza, William J. Sullivan, Jr., Sergio O. Angel, Laura Vanagas
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 23, Iss , Pp 120-129 (2023)
Toxoplasma gondii is an obligate intracellular parasite in the phylum Apicomplexa that causes toxoplasmosis in humans and animals worldwide. Despite its prevalence, there is currently no effective vaccine or treatment for chronic infection. Although
Externí odkaz:
https://doaj.org/article/2ce3428cc04f4bff91f94ea6b5738d6a
Autor:
Sarah L. Sokol-Borrelli, Sarah M. Reilly, Michael J. Holmes, Stephanie B. Orchanian, Mackenzie D. Massmann, Katherine G. Sharp, Leah F. Cabo, Hisham S. Alrubaye, Bruno Martorelli Di Genova, Melissa B. Lodoen, William J. Sullivan, Jon P. Boyle
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
Abstract Identification of regulators of Toxoplasma gondii bradyzoite development and cyst formation is the most direct way to address the importance of parasite development in long-term persistence and reactivation of this parasite. Here we show tha
Externí odkaz:
https://doaj.org/article/308cbfa9402143bbbb45da037f0e7ce1
Publikováno v:
mSphere, Vol 8, Iss 2 (2023)
ABSTRACT Toxoplasma gondii is a widespread protozoan parasite that has a significant impact on human and veterinary health. The parasite undergoes a complex life cycle involving multiple hosts and developmental stages. How Toxoplasma transitions betw
Externí odkaz:
https://doaj.org/article/d71f6d3c612e4326ae8b664dbce978c5
Autor:
Sheila C. Nardelli, Natalie C. Silmon de Monerri, Laura Vanagas, Xiaonan Wang, Zoi Tampaki, William J. Sullivan, Sergio O. Angel, Kami Kim
Publikováno v:
BMC Genomics, Vol 23, Iss 1, Pp 1-17 (2022)
Abstract Background Toxoplasma gondii is a protozoan parasite that differentiates from acute tachyzoite stages to latent bradyzoite forms in response to environmental cues that modify the epigenome. We studied the distribution of the histone variants
Externí odkaz:
https://doaj.org/article/10c23c4f11354703bec2f0af5de0c31f
Autor:
Heather A. Walters, Brenda H. Welter, Harrison C. Moss, Martha A. Villano, Ronny Orobio-Hurtado, William J. Sullivan, Lesly A. Temesvari
Publikováno v:
mSphere, Vol 7, Iss 3 (2022)
ABSTRACT Entamoeba histolytica is a protozoan parasite that causes amoebic dysentery and liver abscess. This pathogen possesses a two-stage life cycle consisting of an environmentally stable cyst and a pathogenic amoeboid trophozoite. Since infection
Externí odkaz:
https://doaj.org/article/c92b3f97245b4200a1ee3271f3aa9a46
Publikováno v:
PLoS Pathogens, Vol 17, Iss 7, p e1009335 (2021)
Toxoplasma gondii is an obligate intracellular parasite that can cause serious opportunistic disease in the immunocompromised or through congenital infection. To progress through its life cycle, Toxoplasma relies on multiple layers of gene regulation
Externí odkaz:
https://doaj.org/article/27befc67810c4456835ec4a6052bc7f2
Autor:
Min Liu, Fen-Xiang Li, Chun-Yuan Li, Xiao-Cong Li, Long-Fei Chen, Kun Wu, Pei-Liang Yang, Zhi-Fa Lai, Ting-kai Liu, William J. Sullivan, Liwang Cui, Xiao-Guang Chen
Publikováno v:
Parasites & Vectors, Vol 12, Iss 1, Pp 1-6 (2019)
Abstract Background Protein arginine methylation is a prevalent post-translational modification. The protein arginine methyltransferase family (PRMT) is involved in many cellular processes in eukaryotes, including transcriptional regulation, epigenet
Externí odkaz:
https://doaj.org/article/9d07e1fb3d994494b113d0d4a1fbd0d8
Autor:
Leonardo Augusto, Jennifer Martynowicz, Parth H. Amin, Kenneth R. Carlson, Ronald C. Wek, William J. Sullivan
Publikováno v:
mBio, Vol 12, Iss 1 (2021)
Toxoplasma gondii
Externí odkaz:
https://doaj.org/article/535c051da52e490ca0480dd67306add6