Zobrazeno 1 - 10
of 104
pro vyhledávání: '"William J, Savage"'
Autor:
Sandeep Jandu, Lakshmi Santhanam, Xu Cao, Bulouere P Wodu, Lacy M. Alexander, Mei Wan, Alan Poe, Guanqiao Liu, William J. Savage, Xiaonan Liu, Weiping Su
Publikováno v:
J Clin Invest
Evidence links osteoporosis and cardiovascular disease but the cellular and molecular mechanisms are unclear. Here we identify skeleton-secreted platelet-derived growth factor-BB (PDGF-BB) as a key mediator of arterial stiffening in response to aging
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c2757daf8d2e89dc81b48ea1cc5652e
https://europepmc.org/articles/PMC8516464/
https://europepmc.org/articles/PMC8516464/
Autor:
James K. Chen, Sandeep Jandu, William J. Savage, Kavitha Nandakumar, Alan Poe, Jochen Steppan, Maria Bauer, Sebastian F. Barreto-Ortiz, Sean Melucci, Huilei Wang, Shivam Rastogi, Lakshmi Santhanam, Sara K. Kang
Publikováno v:
Cell Death Discovery, Vol 7, Iss 1, Pp 1-12 (2021)
Cell Death Discovery
Cell Death Discovery
Tissue transglutaminase (TG2), a multifunctional protein of the transglutaminase family, has putative transamidation-independent functions in aging-associated vascular stiffening and dysfunction. Developing preclinical models will be critical to full
Autor:
Werner Engl, Oleksandra Stasyshyn, Hishamshah Ibrahim, Vlad C. Radulescu, Robert Klamroth, William J. Savage, Bruce Ewenstein, Peter William Collins, Jerzy Windyga, Srilatha Tangada
Publikováno v:
Blood
Rurioctocog alfa pegol prophylaxis targeting factor VIII (FVIII) troughs ≥1% has shown to be efficacious with an acceptable safety profile in people with hemophilia A (PwHA). The PROPEL trial compared safety and efficacy of 2 target FVIII troughs i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52bde50ce0468eeb43f4bc75ad069ea2
https://europepmc.org/articles/PMC8039905/
https://europepmc.org/articles/PMC8039905/
Autor:
Maria G. Beconi, Ravi Krishna Babu, Sophia Nguyen, Venkateshwar Rao, Vu P. Hong, Brian MacDonald, William J. Savage, Srikanth Venkatraman, Cecile Blaustein
Publikováno v:
Blood. 136:41-42
Hepcidin is known as the master regulator of systemic iron homeostasis with reduction in synthesis leading to the development of iron overload. Hepcidin gene expression is negatively modulated by matriptase-2 (MT-2), a liver-specific type II transmem
Autor:
Cecile Blaustein, Sophia Nguyen, Mark Hixon, Maria G. Beconi, Christopher R. King, William J. Savage
Publikováno v:
Blood. 136:14-15
DISC-0974 is a humanized monoclonal anti-HJV antibody with high binding affinity for human, rat and cynomolgus monkey HJV (100 pM, 240 pM and 110 pM Kd, respectively) [Kovac 2016]. DISC-0974 inhibits the interaction between HJV and the key hepcidin r
Autor:
David T. Scadden, Kevin A. Goncalves, Veit Schmelmer, Haley Howell, Steven M. Devine, Jonathan Hoggatt, Jan Pinkas, Patrick C. Falahee, William J. Savage, Sharon L. Hyzy, John F. DiPersio, Katelyn J. Hammond, John C. Davis
Publikováno v:
Blood. 136:31-32
Background . The majority of hematopoietic stem cell (HSC) transplants are performed using peripheral blood mobilized with granulocyte-colony stimulating factor (G-CSF) given over 5 days. The goal of a successful transplant is to reliably mobilize op
Publikováno v:
Transfusion. 57:1818-1826
BACKGROUND Acoustic cell separation uses ultrasound waves to separate cells from plasma to perform plasmapheresis. Although the fundamental process has been studied for decades, no acoustic cell separation has been studied in a disposable plastic for
Autor:
Allan Doctor, Philip C. Spinella, Anne F. Eder, Pablo Cure, Stella T. Chou, Shimian Zou, Simon J. Stanworth, Myron A. Waclawiw, Marie E. Steiner, Naomi L.C. Luban, Martha Sola-Visner, Nahed El Kassar, Catherine Levy, William J. Savage, Jeanne E. Hendrickson, Alan E. Mast, Traci Heath Mondoro, Cassandra D. Josephson, Simone A. Glynn, Melania M. Bembea
Publikováno v:
Transfusion. 57:1568-1581
Autor:
Francisco M. Marty, William J. Savage, James H. Maguire, Ann E. Woolley, Kathleen Dunford, Maureen Okam Achebe, Mary W Montgomery, Sarah Villeda
Publikováno v:
New England Journal of Medicine. 376:939-946
Background Babesiosis, a tickborne zoonotic disease caused by intraerythrocytic protozoa of the genus babesia, is characterized by nonimmune hemolytic anemia that resolves with antimicrobial treatment and clearance of parasitemia. The development of
Autor:
Veit Schmelmer, J. Neale, David T. Scadden, Michael P. Cooke, Glen D. Raffel, Dwight M. Morrow, Jonathan Hoggatt, Jacky Davis, Kevin A. Goncalves, T. Boitano, John F. DiPersio, Haley Howell, William J. Savage, Patrick C. Falahee, Steven M. Devine
Publikováno v:
Annals of the Rheumatic Diseases. 79:701-702
Background:Autologous haematopoietic stem cell (HSC) transplantation is a recommended therapeutic option for selected patients with autoimmune diseases. G-CSF mobilisation of HSCs requires 4-7 days of injections that are associated with significant s