Zobrazeno 1 - 10
of 13
pro vyhledávání: '"William J, Rosoff"'
Publikováno v:
Biophysical Journal. 102:452-460
There is now considerable evidence of the importance of mechanical cues in neuronal development and regeneration. Motivated by the difference in the mechanical properties of the tissue environment between the peripheral (PNS) and central (CNS) nervou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f01c562a2b1d77e4d39abff85d75c321
https://doi.org/10.1016/j.bpj.2011.12.025
https://doi.org/10.1016/j.bpj.2011.12.025
Autor:
Geoffrey J. Goodhill, Kevin Burrage, Irina Vetter, Duncan Mortimer, Peter Dayan, Zac Pujic, Julia Feldner, Timothy G. Vaughan, William J. Rosoff, Linda J. Richards
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Axon guidance by molecular gradients plays a crucial role in wiring up the nervous system. However, the mechanisms axons use to detect gradients are largely unknown. We first develop a Bayesian “ideal observer” analysis of gradient detection by a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5790ebc3767610e13fca0cae6994212d
https://doi.org/10.1073/pnas.0900715106
https://doi.org/10.1073/pnas.0900715106
Publikováno v:
Journal of Neuroscience Methods. 179:278-283
We demonstrate effective guidance of neurites extending from PC12 cells in a three-dimensional collagen matrix using a focused infrared laser. Processes can be redirected in an arbitrarily chosen direction in the imaging plane in approximately 30 min
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::120f9ba15a823f76aa8a1cf0e7bb4534
https://doi.org/10.1016/j.jneumeth.2009.02.004
https://doi.org/10.1016/j.jneumeth.2009.02.004
Publikováno v:
Journal of Neuroscience Methods. 170:220-228
The "pipette" or "growth cone turning" assay is widely used for studying how axons respond to diffusible guidance cues in their environment. However, little quantitative analysis has been presented of the gradient shapes produced by this assay, or ho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3b3737fbe08165a69d4f8ded81d0c5e
https://doi.org/10.1016/j.jneumeth.2008.01.014
https://doi.org/10.1016/j.jneumeth.2008.01.014
Autor:
Geoffrey J. Goodhill, Ryan G. McAllister, William J. Rosoff, Linda J. Richards, Esrick Ma, Jeffrey S. Urbach
Publikováno v:
Nature Neuroscience. 7:678-682
Axonal chemotaxis is believed to be important in wiring up the developing and regenerating nervous system, but little is known about how axons actually respond to molecular gradients. We report a new quantitative assay that allows the long-term respo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b241fb0759dd7d912bb3d34ada636d02
https://doi.org/10.1038/nn1259
https://doi.org/10.1038/nn1259
Autor:
Jeffery S. Urbach, Yasuhiro Katagiri, Pramukta Kumar, Herbert M. Geller, Inn-Inn Chen, Terri-Ann N. Kelly, Keri B. Vartanian, William J. Rosoff
Publikováno v:
Journal of neuroscience research. 88(14)
Inhibition of microtubule dynamic instability prevents growth cone turning in response to guidance cues, yet specific changes in microtubule polymerization as growth cones encounter boundaries have not been investigated. In this study, we examined th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::877d45729b198a943ba65aaaed4be104
https://pubmed.ncbi.nlm.nih.gov/20806407
https://pubmed.ncbi.nlm.nih.gov/20806407
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 571
During development a variety of cell types are guided by molecular concentration gradients to form tissues and organ systems. In the nervous system, the migration and neuronal pathfinding that occurs during development is organized and driven by "gui
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::05188ad65b578e78f5bc86fbf61532fb
https://pubmed.ncbi.nlm.nih.gov/19763971
https://pubmed.ncbi.nlm.nih.gov/19763971
Publikováno v:
Methods in Molecular Biology ISBN: 9781607611974
During development a variety of cell types are guided by molecular concentration gradients to form tissues and organ systems. In the nervous system, the migration and neuronal pathfinding that occurs during development is organized and driven by "gui
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5edd26fec48bd3ae89920ae0cad7d2f8
https://doi.org/10.1007/978-1-60761-198-1_16
https://doi.org/10.1007/978-1-60761-198-1_16
Publikováno v:
Development. 142:2385-2385
It has been suggested that growth cones navigating through the developing nervous system might display adaptation, so that their response to gradient signals is conserved over wide variations in ligand concentration. Recently however, a new chemotaxi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbca31ee74edb8d506df87e6add5989e
https://doi.org/10.1242/dev.127316
https://doi.org/10.1242/dev.127316
Autor:
Jeffrey S. Urbach, Geoffrey J. Goodhill, Ryan R. J. McAllister, M.A. Esrick, William J. Rosoff
Publikováno v:
Biotechnology and bioengineering. 91(6)
A new method for producing molecular gradients of arbitrary shape in thin three dimensional gels is described. Patterns are produced on the surface of the gel by printing with a micropump that dispenses small droplets of solution at controlled rates.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8bc01a6cb8bedbfa611fc2e2fcc3a6e
https://pubmed.ncbi.nlm.nih.gov/15981274
https://pubmed.ncbi.nlm.nih.gov/15981274