Zobrazeno 1 - 10
of 59
pro vyhledávání: '"William J, Reagan"'
Autor:
Jiangwei Zhang, Sarah Campion, Natasha Catlin, William J. Reagan, Kiran Palyada, Shashi K. Ramaiah, Ragu Ramanathan
Publikováno v:
Archives of Toxicology. 97:947-961
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::452f2e569b9a5ceb38e406624dd63a40
https://doi.org/10.1007/s00204-023-03460-0
https://doi.org/10.1007/s00204-023-03460-0
Autor:
William J. Reagan, Marjory B. Brooks, Renata Grozovsky, Debra Pittman, Allison Vitsky, Karrie Brenneman
Publikováno v:
Toxicologic Pathology. 50:890-894
The session on the hemostatic system focused on new developments in coagulation and platelet biology as well as how therapeutic agents may affect hemostasis. The classic cascade model of coagulation was compared with the more recent models of cell-ba
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aad046bc1107a1e3369cf578b9129391
https://doi.org/10.1177/01926233221125172
https://doi.org/10.1177/01926233221125172
Publikováno v:
Schalm's Veterinary Hematology. :85-92
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a44547f4f55397dc8902ed5f20542ad8
https://doi.org/10.1002/9781119500537.ch10
https://doi.org/10.1002/9781119500537.ch10
Autor:
Jean G. Sathish, Siddhartha Bhatt, Jamie K. DaSilva, Declan Flynn, Stephen Jenkinson, Amit S. Kalgutkar, Maggie Liu, Balasubramanian Manickam, Jason Pinkstaff, William J. Reagan, Norimitsu Shirai, Ahmed M. Shoieb, Madhu Sirivelu, Saurabh Vispute, Allison Vitsky, Karen Walters, Todd A. Wisialowski, Lawrence W. Updyke
Publikováno v:
International journal of toxicology. 41(4)
COVID-19 is a potentially fatal infection caused by the SARS-CoV-2 virus. The SARS-CoV-2 3CL protease (Mpro) is a viral enzyme essential for replication and is the target for nirmatrelvir. Paxlovid (nirmatrelvir co-administered with the pharmacokinet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cea1a7a89320457f06d9cf5a899cc71f
https://pubmed.ncbi.nlm.nih.gov/35603517
https://pubmed.ncbi.nlm.nih.gov/35603517
Autor:
Rani S. Sellers, Ahmed M. Shoieb, Shelli J. Schomaker, William J. Reagan, David W. Clarke, Victoria Markiewicz
Publikováno v:
Toxicologic Pathology. 48:845-856
The objectives were to characterize the kinetics of acute phase proteins (APPs) α-2 macroglobulin (A2M), α-1 acid glycoprotein (A1AGP), and fibrinogen (FIB), and injection site macroscopic and microscopic findings following intramuscular administra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85c94467c3a93989a7a1badc445ab0ca
https://doi.org/10.1177/0192623320957281
https://doi.org/10.1177/0192623320957281
Autor:
David A. Beebe, Gregg D. Cappon, Michelle Clasquin, Marc K. Hellerstein, Norimitsu Shirai, William J. Reagan, Zhongyuan Sun, Katherine Hales, Gabriele E. Sonnenberg, Jeffrey A. Pfefferkorn, Theodore J. Schmahai, Nicholas B. Vera, Marcy Matthews, Trenton T. Ross, Clare Buckeridge, Enida Ziso Qejvanaj, Kenneth L. Kelly, Shoh Asano, Santos Carvajal-Gonzalez, William P. Esler, Paul A. Amor, Kelvin W. Li, Arthur Bergman
Publikováno v:
Nature Metabolism. 2:1163-1178
Acetyl-CoA carboxylase (ACC) catalyses the first step of de novo lipogenesis (DNL). Pharmacologic inhibition of ACC has been of interest for therapeutic intervention in a wide range of diseases. We demonstrate here that ACC and DNL are essential for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37212bb75eaf160e3e8857af5cd7c6c9
https://doi.org/10.1038/s42255-020-00272-9
https://doi.org/10.1038/s42255-020-00272-9
Autor:
Torrie A Crabbs, Maralee McVean, William J. Reagan, Martin Sanders, Laura Dill Morton, Kathleen A. Funk
Publikováno v:
International Journal of Toxicology. 38:228-234
A number of issues may arise during the conduct of a study which can complicate interpretation of in vitro and in vivo datasets. Speakers discussed the implications of differing interpretations and how to avoid complicating factors during study plann
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c3fd425bf1d8ecdafe678488a24d456
https://doi.org/10.1177/1091581819837157
https://doi.org/10.1177/1091581819837157
Autor:
J. Eric McDuffie, William J. Reagan, Joanna Harding, James D. Smith, Dominique Brees, Tanja S. Zabka, Magali Guffroy, Deidre A. Dalmas, Jean-Charles Gautier, Lila Ramaiah, Alison Wolfreys, John E. Burkhardt, A. Eric Schultze, Warren E. Glaab
Publikováno v:
Regulatory toxicology and pharmacology : RTP. 120
Pharmaceutical and biotechnology companies rarely disclose their use of translational emerging safety biomarkers (ESBs) during drug development, and the impact of ESB use on the speed of drug development remains unclear. A cross-industry survey of 20
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43b5cd09e29bfbf7127c37f6846504a0
https://pubmed.ncbi.nlm.nih.gov/33387566
https://pubmed.ncbi.nlm.nih.gov/33387566
Autor:
Susan Hurst, Cedo M. Bagi, Mark Zorbas, William J. Reagan, Mark G. Evans, Kathryn E. Gropp, Cathy S. Carlson, David L. Shelton
Publikováno v:
Toxicologic Pathology. 46:408-420
Tanezumab, an anti-nerve growth factor (NGF) antibody, is in development for management of chronic pain. During clinical trials of anti-NGF antibodies, some patients reported unexpected adverse events requiring total joint replacements, resulting in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e4642fcbc6e8f570aa32349e69b8df3
https://doi.org/10.1177/0192623318772501
https://doi.org/10.1177/0192623318772501
Autor:
Rachel Roach, Joseph Sergi, Mark Horn, Mike Favis, Jeanne Sue Magram, Victoria Markiewicz, William B. Snyder, Kymberly Levine, Jennifer Colangelo, Jean Chamoun, Moosa Mohammadi, Jacqueline Vekich, Dikran Aivazian, Edwin Berryman, William J. Reagan, Cedo M. Bagi, Kristen Johnson, Anthony J. Coyle, Brian Robert Miller, Xianjun Cao, Thomas P. Brown
Publikováno v:
Journal of Bone and Mineral Research. 32:2062-2073
Fibroblast growth factor 23 (FGF23) is the causative factor of X-linked hypophosphatemia (XLH), a genetic disorder effecting 1:20,000 that is characterized by excessive phosphate excretion, elevated FGF23 levels and a rickets/osteomalacia phenotype.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a7a0463bfb83c9e8e3ec98297dad41ba
https://doi.org/10.1002/jbmr.3197
https://doi.org/10.1002/jbmr.3197