Zobrazeno 1 - 10
of 39
pro vyhledávání: '"William J, Meilandt"'
Autor:
Max Adrian, Martin Weber, Ming-Chi Tsai, Caspar Glock, Olga I. Kahn, Lilian Phu, Tommy K. Cheung, William J. Meilandt, Christopher M. Rose, Casper C. Hoogenraad
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
Abstract Microglial reactivity is a pathological hallmark in many neurodegenerative diseases. During stimulation, microglia undergo complex morphological changes, including loss of their characteristic ramified morphology, which is routinely used to
Externí odkaz:
https://doaj.org/article/07f1bdd5b8fc4c30814079f35fbb9f55
Autor:
William J. Meilandt, Janice A. Maloney, Jose Imperio, Guita Lalehzadeh, Tim Earr, Susan Crowell, Travis W. Bainbridge, Yanmei Lu, James A. Ernst, Reina N. Fuji, Jasvinder K. Atwal
Publikováno v:
Alzheimer’s Research & Therapy, Vol 11, Iss 1, Pp 1-14 (2019)
Abstract Background Accumulation of amyloid β (Aβ) in the brain is proposed as a cause of Alzheimer’s disease (AD), with Aβ oligomers hypothesized to be the primary mediators of neurotoxicity. Crenezumab is a humanized immunoglobulin G4 monoclon
Externí odkaz:
https://doaj.org/article/bd282779d343414aa689f312c255a80f
Autor:
Brad A. Friedman, Karpagam Srinivasan, Gai Ayalon, William J. Meilandt, Han Lin, Melanie A. Huntley, Yi Cao, Seung-Hye Lee, Patrick C.G. Haddick, Hai Ngu, Zora Modrusan, Jessica L. Larson, Joshua S. Kaminker, Marcel P. van der Brug, David V. Hansen
Publikováno v:
Cell Reports, Vol 22, Iss 3, Pp 832-847 (2018)
Microglia, the CNS-resident immune cells, play important roles in disease, but the spectrum of their possible activation states is not well understood. We derived co-regulated gene modules from transcriptional profiles of CNS myeloid cells of diverse
Externí odkaz:
https://doaj.org/article/7afe276a5f3e4ad1a1ced4ec793c120a
Autor:
Tiffany Wu, Borislav Dejanovic, Vineela D. Gandham, Alvin Gogineni, Rose Edmonds, Stephen Schauer, Karpagam Srinivasan, Melanie A. Huntley, Yuanyuan Wang, Tzu-Ming Wang, Maj Hedehus, Kai H. Barck, Maya Stark, Hai Ngu, Oded Foreman, William J. Meilandt, Justin Elstrott, Michael C. Chang, David V. Hansen, Richard A.D. Carano, Morgan Sheng, Jesse E. Hanson
Publikováno v:
Cell Reports, Vol 28, Iss 8, Pp 2111-2123.e6 (2019)
Summary: Complement pathway overactivation can lead to neuronal damage in various neurological diseases. Although Alzheimer’s disease (AD) is characterized by β-amyloid plaques and tau tangles, previous work examining complement has largely focuse
Externí odkaz:
https://doaj.org/article/6cf938f6916a4deca5b7f57d27bda622
Autor:
Shraddha S, Sadekar, Mayumi, Bowen, Hao, Cai, Samira, Jamalian, Hanine, Rafidi, Whitney, Shatz-Binder, Julien, Lafrance-Vanasse, Pamela, Chan, William J, Meilandt, Amy, Oldendorp, Alavattam, Sreedhara, Ann, Daugherty, Susan, Crowell, Kristin R, Wildsmith, Jasvinder, Atwal, Reina N, Fuji, Joshua, Horvath
Publikováno v:
Clinical Pharmacology & Therapeutics. 111:826-834
Delivery of biologics via cerebrospinal fluid (CSF) has demonstrated potential to access the tissues of the central nervous system (CNS) by circumventing the blood-brain barrier and blood-CSF barrier. Developing an effective CSF drug delivery strateg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bd4af582ed8aa4819475cceff982f1d
https://doi.org/10.1002/cpt.2531
https://doi.org/10.1002/cpt.2531
Autor:
Hu Zeng, Jiahao Huang, Haowen Zhou, William J. Meilandt, Borislav Dejanovic, Yiming Zhou, Christopher J. Bohlen, Seung-Hye Lee, Jingyi Ren, Albert Liu, Zefang Tang, Hao Sheng, Jia Liu, Morgan Sheng, Xiao Wang
Publikováno v:
Nature Neuroscience.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ad76c79c7fc88578c681c7e45bd3d5b7
https://doi.org/10.1038/s41593-022-01251-x
https://doi.org/10.1038/s41593-022-01251-x
Autor:
Hai Ngu, Sara L. Dominguez, Michelle Dourado, Timothy K. Earr, William J. Meilandt, Jesse E. Hanson
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Scientific Reports
Scientific Reports
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by motor neuron loss that ultimately leads to fatal paralysis. Reducing levels or function of the tyrosine kinase, ephrin type-A receptor 4 (EphA4), has been suggested a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6181d14f6ebecd3bfe868a21dd011210
http://link.springer.com/article/10.1038/s41598-020-72723-y
http://link.springer.com/article/10.1038/s41598-020-72723-y
Autor:
Agatha J. Kruse, William J. Meilandt, Guita Lalehzadeh, Hai Ngu, Oded Foreman, Martin Weber, Jose Imperio, Tiffany Wu, Morgan Sheng, David V. Hansen, Kimberly L. Stark, Zora Modrusan, Mandy Kwong, Karpagam Srinivasan, Brad A. Friedman, Alvin Gogineni, Amy Easton, Seung-Hye Lee, Pamela Chan, Justin Elstrott
Publikováno v:
The Journal of Neuroscience
Frontiers in Aging Neuroscience
Frontiers in Aging Neuroscience
TREM2 is an Alzheimer's disease (AD) risk gene expressed in microglia. To study the role of Trem2 in a mouse model of β-amyloidosis, we compared PS2APP transgenic mice versus PS2APP mice lacking Trem2 (PS2APP;Trem2ko) at ages ranging from 4 to 22 mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dde2ded43e8f4be3d4d41f91364b402d
http://europepmc.org/articles/PMC7046459
http://europepmc.org/articles/PMC7046459
Autor:
Hu Zeng, Jiahao Huang, Haowen Zhou, William J. Meilandt, Borislav Dejanovic, Yiming Zhou, Christopher J. Bohlen, Seung-Hye Lee, Jingyi Ren, Albert Liu, Hao Sheng, Jia Liu, Morgan Sheng, Xiao Wang
Amyloid-β plaques and neurofibrillary tau tangles are the neuropathologic hallmarks of Alzheimer’s disease (AD), but the spatiotemporal cellular responses and molecular mechanisms underlying AD pathophysiology remain poorly understood. Here we int
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eb701e380dbe3196dd4af8c6d3dde962
https://doi.org/10.1101/2022.01.14.476072
https://doi.org/10.1101/2022.01.14.476072
Autor:
James A. Ernst, Tim Earr, Guita Lalehzadeh, Travis W. Bainbridge, Susan Crowell, William J. Meilandt, Jose Imperio, Reina N. Fuji, Yanmei Lu, Janice A. Maloney, Jasvinder K. Atwal
Publikováno v:
Alzheimer’s Research & Therapy, Vol 11, Iss 1, Pp 1-14 (2019)
Alzheimer's Research & Therapy
Alzheimer's Research & Therapy
Background Accumulation of amyloid β (Aβ) in the brain is proposed as a cause of Alzheimer’s disease (AD), with Aβ oligomers hypothesized to be the primary mediators of neurotoxicity. Crenezumab is a humanized immunoglobulin G4 monoclonal antibo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd56a26eaed0bb2a4cfdf03b4b10e492
https://doaj.org/article/bd282779d343414aa689f312c255a80f
https://doaj.org/article/bd282779d343414aa689f312c255a80f