Zobrazeno 1 - 10
of 76
pro vyhledávání: '"William J, LaRochelle"'
Autor:
Michael Jeffers, Henri S. Lichenstein, Maxwell Sehested, Annemette Thougaard, Kamille Dumong Petersen, Frank Wu, Gulshan Ara, William J. LaRochelle, Xiaozhong Qian
Supplemental Table S2 from Activity of PXD101, a histone deacetylase inhibitor, in preclinical ovarian cancer studies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40168a14b344b02e05f1362451352fda
https://doi.org/10.1158/1535-7163.22484604.v1
https://doi.org/10.1158/1535-7163.22484604.v1
Data from Activity of PXD101, a histone deacetylase inhibitor, in preclinical ovarian cancer studies
Autor:
Michael Jeffers, Henri S. Lichenstein, Maxwell Sehested, Annemette Thougaard, Kamille Dumong Petersen, Frank Wu, Gulshan Ara, William J. LaRochelle, Xiaozhong Qian
Histone deacetylase inhibitors represent a promising new class of anticancer agents. In the current investigation, we examined the activity of PXD101, a potent histone deacetylase inhibitor, used alone or in combination with clinically relevant chemo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c0c4d95e56c2198a6e958a16e2a4799
https://doi.org/10.1158/1535-7163.c.6531480
https://doi.org/10.1158/1535-7163.c.6531480
Autor:
Elise C. Kohn, Joshua Cohen, William J. LaRochelle, Gulshan Ara, Haihong Zhong, Nabila Rasool
Publikováno v:
Clinical Cancer Research. 16:600-609
Purpose: Ovarian cancer recurrence with the development of paclitaxel resistance is an obstacle to long-term survival. We showed that secretory leukocyte protease inhibitor (SLPI) is a survival factor for ovarian cancer. We hypothesize that SLPI may
Autor:
Stephen T. Sonis, Brynmor A. Watkins, William J. Larochelle, Cyrus Karkaria, Gulshan Ara, Thomas R Hawthorne, Haihong Zhong
Publikováno v:
International Journal of Radiation Biology. 84:401-412
Velafermin (recombinant human fibroblast growth factor-20, rhFGF-20) has been shown to reduce the severity and duration of mucositis in preclinical acute (single dose) radiation and chemotherapy/radiation models of oral mucositis. Our present study a
Autor:
William J. LaRochelle, Henri Lichenstein, Michael Jeffers, Gulshan Ara, Evan Mills, Xiaozhong Qian
Publikováno v:
International Journal of Cancer. 122:1400-1410
Histone deacetylase inhibitors (HDACi) represent a promising new class of anticancer agents. In the current investigation, we examined the activity of the HDACi belinostat in preclinical models of prostate cancer. In vitro proliferation assays demons
Autor:
Kam Fai Tse, Vincent A. Pollack, Michael Jeffers, Haihong Zhong, William J. LaRochelle, John Macdougall, Sharon Arrol, William F. Hahne, Suresh Shenoy, Henri Lichenstein, Michael Torgov, Sam Xie, Robert W. Gerwien, Peter D. Senter, Enrique Alvarez
Publikováno v:
Cancer Chemotherapy and Pharmacology. 60:423-435
To investigate the pharmacological properties of the CR011-vcMMAE fully human antibody-drug conjugate (ADC), such as dose titrations, quantitation of the time (days) to complete regression, pharmacokinetics, and schedule dependency. Our prior study c
Autor:
Iris Behrmann, Juergen Floege, Henri S. Lichenstein, A. Chaudhuri, C. R. van Roeyen, Dirk Bokemeyer, C. E. Pena, Frank Strutz, William J. LaRochelle, Tammo Ostendorf, Bernd Denecke
Publikováno v:
Kidney International. 69(8):1393-1402
Platelet-derived growth factor (PDGF)-BB and PDGF-DD mediate mesangial cell proliferation in vitro and in vivo. While PDGF-BB is a ligand for the PDGF alpha- and beta-receptor chains, PDGF-DD binds more selectively to the beta-chain, suggesting poten
Publikováno v:
Biochemical and Biophysical Research Communications. 333:308-315
The process of angiogenesis plays a pivotal role in embryogenesis, wound healing, and tumorigenesis through the growth of new blood vessels from pre-existing vasculature. Among the angiogenic factors recently identified as specific for vascular endot
Autor:
Jeffrey D. Peterson, Gadi Gazit-Bornstein, Claudia R.C. van Roeyen, William J. LaRochelle, Avin J. Hamad, Gerlinde Chan, Xiao-Chi Jia, Frank Eitner, Tammo Ostendorf, Jennifer Macaluso, Bruce Keyt, Jürgen Floege, Henri S. Lichenstein, Uta Kunter
Publikováno v:
Journal of the American Society of Nephrology. 14:2237-2247
PDGF-B is of central importance in mesangioproliferative diseases. PDGF-D, a new PDGF isoform, like PDGF-B, signals through the PDGF betabeta-receptor. The present study first determined that PDGF-D is mitogenic for rat mesangial cells and is not inh
Publikováno v:
Expert Opinion on Therapeutic Targets. 6:469-482
The fibroblast growth factor (FGF) family of signalling molecules and its receptors (FGFRs) contribute to normal developmental and physiological processes. However, the subversion of this powerful growth stimulatory pathway has been implicated in the