Zobrazeno 1 - 10
of 36
pro vyhledávání: '"William J, Kowalski"'
Autor:
William J. Kowalski, Iris H. Garcia-Pak, Wenling Li, Hideki Uosaki, Emmanouil Tampakakis, Jizhong Zou, Yongshun Lin, Kira Patterson, Chulan Kwon, Yoh-Suke Mukouyama
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Embryos devoid of autonomic innervation suffer sudden cardiac death. However, whether autonomic neurons have a role in heart development is poorly understood. To investigate if sympathetic neurons impact cardiomyocyte maturation, we co-cultured pheno
Externí odkaz:
https://doaj.org/article/14a91070c479432383e8020dc3ae523c
Autor:
Marc Dwenger, William J Kowalski, Fei Ye, Fangping Yuan, Joseph P Tinney, Shuji Setozaki, Takeichiro Nakane, Hidetoshi Masumoto, Peter Campbell, William Guido, Bradley B Keller
Publikováno v:
Journal of Tissue Engineering, Vol 10 (2019)
The immaturity of human induced pluripotent stem cell derived engineered cardiac tissues limits their ability to regenerate damaged myocardium and to serve as robust in vitro models for human disease and drug toxicity studies. Several chronic biomime
Externí odkaz:
https://doaj.org/article/c59b46060f414c0cb2eeff613521f0f7
Publikováno v:
Journal of Cardiovascular Development and Disease, Vol 7, Iss 2, p 23 (2020)
The goal of this review is to provide a broad overview of the biomechanical maturation and regulation of vertebrate cardiovascular (CV) morphogenesis and the evidence for mechanistic relationships between function and form relevant to the origins of
Externí odkaz:
https://doaj.org/article/0296e46f107042b69e3da795e7aaef07
Publikováno v:
PLoS ONE, Vol 11, Iss 8, p e0161611 (2016)
The role of hemodynamic forces within the embryo as biomechanical regulators for cardiovascular morphogenesis, growth, and remodeling is well supported through the experimental studies. Furthermore, clinical experience suggests that perturbed flow di
Externí odkaz:
https://doaj.org/article/3c84835b7935414cb57f12517749bbed
Autor:
Amir Saberi, Emmanouil Tampakakis, Stephanie Glavaris, Chulan Kwon, William J. Kowalski, Brian L. Lin, Yoh-suke Mukouyama, Myo Htet, Sean Murphy, Ting Liu, Matthew Miyamoto, Harshi Gangrade, Gabsang Lee, Liliana Minichiello
Publikováno v:
Science Advances
Description
Neurons regulate cardiomyocyte proliferation through clock genes.
Neurons can regulate the development, pathogenesis, and regeneration of target organs. However, the role of neurons during heart development and regeneration rema
Neurons regulate cardiomyocyte proliferation through clock genes.
Neurons can regulate the development, pathogenesis, and regeneration of target organs. However, the role of neurons during heart development and regeneration rema
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d1c43b41ded39567330eff636d7de33
https://ora.ox.ac.uk/objects/uuid:08c4d760-1909-4cc5-891f-ebdba67589af
https://ora.ox.ac.uk/objects/uuid:08c4d760-1909-4cc5-891f-ebdba67589af
Publikováno v:
Frontiers in Physiology, Vol 5 (2014)
Innovative research on the interactions between biomechanical load and cardiovascular (CV) morphogenesis by multiple investigators over the past 3 decades, including the application of bioengineering approaches, has shown that the embryonic heart ada
Externí odkaz:
https://doaj.org/article/598055290a41474fae671b5c2f4cfaf0
Autor:
William J Kowalski, Onur Dur, Yajuan Wang, Michael J Patrick, Joseph P Tinney, Bradley B Keller, Kerem Pekkan
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e60271 (2013)
Transformation from the bilaterally symmetric embryonic aortic arches to the mature great vessels is a complex morphogenetic process, requiring both vasculogenic and angiogenic mechanisms. Early aortic arch development occurs simultaneously with rapi
Externí odkaz:
https://doaj.org/article/8d79e0d5bba74adcb033a2afb33f7bf2
Chronic Optogenetic Pacing of Human-Induced Pluripotent Stem Cell-Derived Engineered Cardiac Tissues
Autor:
Marc, Dwenger, William J, Kowalski, Hidetoshi, Masumoto, Takeichiro, Nakane, Bradley B, Keller
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2191
The delivery of cells into damaged myocardium induces limited cardiac regeneration due to extensive cell death. In an effort to limit cell death, our lab formulates three-dimensional matrices as a delivery system for cell therapy. Our primary work ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d750ec7b2c5d64b5f4ec1df367e0abdb
https://pubmed.ncbi.nlm.nih.gov/32865744
https://pubmed.ncbi.nlm.nih.gov/32865744
Chronic Optogenetic Pacing of Human-Induced Pluripotent Stem Cell-Derived Engineered Cardiac Tissues
Publikováno v:
Methods in Molecular Biology ISBN: 9781071608296
The delivery of cells into damaged myocardium induces limited cardiac regeneration due to extensive cell death. In an effort to limit cell death, our lab formulates three-dimensional matrices as a delivery system for cell therapy. Our primary work ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f262b46bc495ed6d0e310de14619cd24
https://doi.org/10.1007/978-1-0716-0830-2_10
https://doi.org/10.1007/978-1-0716-0830-2_10
Autor:
Chulan Kwon, Harshi Gangrade, Yosuke Mukoyama, Emmanouil Tampakakis, Sean Murphy, William J. Kowalski
Publikováno v:
Circulation Research. 127
Sympathetic neurons (SNs) regulate heart rate, conduction velocity, contractility and relaxation of the myocardium. Disruption of SNs in adult cardiac disease, leads to arrhythmias, myocardial dysfunction and sudden cardiac death. However, the role o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dcb479fbd8b1a370921d326c1b5c7cba
https://doi.org/10.1161/res.127.suppl_1.102
https://doi.org/10.1161/res.127.suppl_1.102