Zobrazeno 1 - 10
of 240
pro vyhledávání: '"William J, Kelly"'
Autor:
Henriette U. Balinda, William J. Kelly, Virginia G. Kaklamani, Kate I. Lathrop, Marcela Mazo Canola, Pegah Ghamasaee, Gangadhara R. Sareddy, Joel Michalek, Andrea R. Gilbert, Prathibha Surapaneni, Stefano Tiziani, Renu Pandey, Jennifer Chiou, Alessia Lodi, John R. Floyd, Andrew J. Brenner
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract Sacituzumab Govitecan (SG) is an antibody-drug conjugate that has demonstrated efficacy in patients with TROP-2 expressing epithelial cancers. In a xenograft model of intracranial breast cancer, SG inhibited tumor growth and increased mouse
Externí odkaz:
https://doaj.org/article/6d91bfe0b91b4bbd854a96e2dea7ba0a
Autor:
William J. Kelly, Roderick I. Mackie, Graeme T. Attwood, Peter H. Janssen, Tim A. McAllister, Sinead C. Leahy
Publikováno v:
Animal Microbiome, Vol 4, Iss 1, Pp 1-8 (2022)
Abstract Molecular hydrogen (H2) and formate (HCOO−) are metabolic end products of many primary fermenters in the mammalian gut. Both play a vital role in fermentation where they are electron sinks for individual microbes in an anaerobic environmen
Externí odkaz:
https://doaj.org/article/94e1399cc8b64047af09d77ca30ea96f
Autor:
Vincenzo Carbone, Kerri Reilly, Carrie Sang, Linley R. Schofield, Ron S. Ronimus, William J. Kelly, Graeme T. Attwood, Nikola Palevich
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 18, p 13738 (2023)
Pectin is a complex polysaccharide that forms a substantial proportion of the plant’s middle lamella of forage ingested by grazing ruminants. Methanol in the rumen is derived mainly from methoxy groups released from pectin by the action of pectin m
Externí odkaz:
https://doaj.org/article/647b0ff60c0243148b4a83da3b133bb6
Publikováno v:
Current Research in Microbial Sciences, Vol 4, Iss , Pp 100189- (2023)
Rumen methanogenic archaea use by-products of fermentation to carry out methanogenesis for energy generation. A key fermentation by-product is hydrogen (H2), which acts as the source of reducing potential for methane (CH4) formation in hydrogenotroph
Externí odkaz:
https://doaj.org/article/d8f1cae07fea46f6a0259434afd8f2ef
Autor:
William J. Kelly, Sinead C. Leahy, Janine Kamke, Priya Soni, Satoshi Koike, Roderick Mackie, Rekha Seshadri, Gregory M. Cook, Sergio E. Morales, Chris Greening, Graeme T. Attwood
Publikováno v:
Animal Microbiome, Vol 1, Iss 1, Pp 1-13 (2019)
Abstract Background Digestive processes in the rumen lead to the release of methyl-compounds, mainly methanol and methylamines, which are used by methyltrophic methanogens to form methane, an important agricultural greenhouse gas. Methylamines are pr
Externí odkaz:
https://doaj.org/article/505f514c14fa43ad9415cc8c53bedecd
Publikováno v:
Bergey's Manual of Systematics of Archaea and Bacteria. :1-6
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a96c3c69ca11f371653b2a57b8bab363
https://doi.org/10.1002/9781118960608.gbm01738
https://doi.org/10.1002/9781118960608.gbm01738
Autor:
Brooks Hopkins, Justin Fisher, Meiping Chang, Xiaoyan Tang, Zhimei Du, William J. Kelly, Zuyi Huang
Publikováno v:
Cells, Vol 11, Iss 10, p 1701 (2022)
The growth of T cells ex vivo for the purpose of T cell therapies is a rate-limiting step in the overall process for cancer patients to achieve remission. Growing T cells is a fiscally-, time-, and resource-intensive process. Cytokines have been show
Externí odkaz:
https://doaj.org/article/cdb45f5adafa4db4bece1b1ef2d96cf7
Publikováno v:
Human Vaccines & Immunotherapeutics, Vol 14, Iss 2, Pp 269-276 (2018)
Immunotherapy as a therapeutic strategy has seized the narrative throughout clinical oncology over the past few years. Once considered a niche treatment for rare cancers, immunotherapy has quickly emerged as the standard of care for many common cance
Externí odkaz:
https://doaj.org/article/a170d15766174452b5b5f8d2928a94a3
Autor:
Vadim S. Koshkin, Pedro C. Barata, Tian Zhang, Daniel J. George, Michael B. Atkins, William J. Kelly, Nicholas J. Vogelzang, Sumanta K. Pal, JoAnn Hsu, Leonard J. Appleman, Moshe C. Ornstein, Timothy Gilligan, Petros Grivas, Jorge A. Garcia, Brian I. Rini
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 6, Iss 1, Pp 1-7 (2018)
Abstract Background Nivolumab is approved for patients with metastatic renal cell carcinoma (mRCC) refractory to prior antiangiogenic therapy. The clinical activity of nivolumab in patients with non-clear cell RCC subtypes remains unknown as these pa
Externí odkaz:
https://doaj.org/article/bbc492fd73414e95b44026496b015f42
Autor:
Nikola Palevich, William J. Kelly, Sinead C. Leahy, Eric Altermann, Jasna Rakonjac, Graeme T. Attwood
Publikováno v:
Standards in Genomic Sciences, Vol 12, Iss 1, Pp 1-14 (2017)
Abstract Butyrivibrio hungatei MB2003 was isolated from the plant-adherent fraction of rumen contents from a pasture-grazed New Zealand dairy cow, and was selected for genome sequencing in order to examine its ability to degrade plant polysaccharides
Externí odkaz:
https://doaj.org/article/7ba65e541e054a6aad79f9545c626439